Home Other Building Blocks 227963-15-7
227963-15-7,MFCD27665469
Catalog No.:AA01FTOQ

227963-15-7 | MK-0429

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
1 week  
$765.00   $535.00
- +
10mg
99%
1 week  
$1,241.00   $869.00
- +
50mg
99%
1 week  
$3,622.00   $2,535.00
- +
100mg
99%
1 week  
$5,368.00   $3,758.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01FTOQ
Chemical Name:
MK-0429
CAS Number:
227963-15-7
Molecular Formula:
C23H29N5O4
Molecular Weight:
439.5075
MDL Number:
MFCD27665469
SMILES:
COc1ccc(cn1)[C@@H](N1CCN(C1=O)CCCc1ccc2c(n1)NCCC2)CC(=O)O
Properties
Computed Properties
 
Complexity:
650  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
1.8  

Literature

Title: Hutchinson JH, et al. Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis. J Med Chem. 2003 Oct 23;46(22):4790-8.

Title: Pickarski M, et al. Orally active αvβ3 integrin inhibitor MK-0429 reduces melanoma metastasis. Oncol Rep. 2015 Jun;33(6):2737-45.

Title: Xiaoyan Zhou, et al. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model. Pharmacol Res Perspect. 2017 Oct;5(5):e00354.

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SDS
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