Title: Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20181001
Title: Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea.
Journal: Toxicology letters 20180901
Title: Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin.
Journal: Chemico-biological interactions 20180625
Title: Silymarin attenuated paraquat-induced cytotoxicity in macrophage by regulating Trx/TXNIP complex, inhibiting NLRP3 inflammasome activation and apoptosis.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180201
Title: Hepatoprotective effect of 10% ethanolic extract from Curdrania tricuspidata leaves against ethanol-induced oxidative stress through suppression of CYP2E1.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001
Title: Evaluation of ameliorative ability of Silibinin against zidovudine and isoniazid-induced hepatotoxicity and hyperlipidaemia in rats: Role of Silibinin in Phase I and II drug metabolism.
Journal: Chemico-biological interactions 20170801
Title: Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-κB mediated inflammation and apoptosis in experimental gastric ulcer.
Journal: Chemico-biological interactions 20170801
Title: Dual effect of silymarin on experimental non-alcoholic steatohepatitis induced by irinotecan.
Journal: Toxicology and applied pharmacology 20170715
Title: Natural antioxidant flavonoids in formalin-induced mice paw inflammation; inhibition of mitochondrial sorbitol dehydrogenase activity.
Journal: Journal of biochemical and molecular toxicology 20170701
Title: Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170701
Title: The effect of milk thistle (Silybum marianum) and its main flavonolignans on CYP2C8 enzyme activity in human liver microsomes.
Journal: Chemico-biological interactions 20170601
Title: Hesperetin derivative-14 alleviates inflammation by activating PPAR-γ in mice with CCl(4)-induced acute liver injury and LPS-treated RAW264.7 cells.
Journal: Toxicology letters 20170515
Title: Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170401
Title: Hepatoprotective effect of 2'-O-galloylhyperin against oxidative stress-induced liver damage through induction of Nrf2/ARE-mediated antioxidant pathway.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170401
Title: Protective Effects of Ecklonia stolonifera Extract on Ethanol-Induced Fatty Liver in Rats.
Journal: Biomolecules & therapeutics 20161101
Title: Tangeretin attenuates cisplatin-induced renal injury in rats: Impact on the inflammatory cascade and oxidative perturbations.
Journal: Chemico-biological interactions 20161025
Title: Silibinin Inhibits Proliferation and Migration of Human Hepatic Stellate LX-2 Cells.
Journal: Journal of clinical and experimental hepatology 20160901
Title: Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats.
Journal: Environmental toxicology 20160501
Title: Taurine zinc solid dispersions attenuate doxorubicin-induced hepatotoxicity and cardiotoxicity in rats.
Journal: Toxicology and applied pharmacology 20151115
Title: Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway.
Journal: Chemico-biological interactions 20151005
Title: Effects of Melatonin-Aided Therapy on the Glutathione Antioxidant System Activity and Liver Protection.
Journal: Journal of biochemical and molecular toxicology 20151001
Title: Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats.
Journal: Toxicology letters 20150917
Title: Assessment of hepatoprotective potential of N. indicum leaf on haloalkane xenobiotic induced hepatic injury in Swiss albino mice.
Journal: Chemico-biological interactions 20150625
Title: Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice.
Journal: Chemico-biological interactions 20150325
Title: Blockade of lipid accumulation by silibinin in adipocytes and zebrafish.
Journal: Chemico-biological interactions 20150205
Title: Silibinin combination with arsenic strongly inhibits survival and invasiveness of human prostate carcinoma cells.
Journal: Nutrition and cancer 20150101
Title: Protective role of silymarin against manganese-induced nephrotoxicity and oxidative stress in rat.
Journal: Environmental toxicology 20141001
Title: Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140501
Title: The binding of silibinin to ERp57.
Journal: Chemico-biological interactions 20140425
Title: Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.
Journal: Chemico-biological interactions 20140325
Title: Silibinin potentially attenuates arsenic-induced oxidative stress mediated cardiotoxicity and dyslipidemia in rats.
Journal: Cardiovascular toxicology 20140301
Title: Silymarin prevents the toxicity induced by benzo(a)pyrene in human erythrocytes by preserving its membrane integrity: an in vitro study.
Journal: Environmental toxicology 20140201
Title: Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach.
Journal: Toxicology and applied pharmacology 20140115
Title: Saussurea lappa alleviates inflammatory chemokine production in HaCaT cells and house dust mite-induced atopic-like dermatitis in Nc/Nga mice.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140101
Title: Leukocyte production of inflammatory mediators is inhibited by the antioxidants phloretin, silymarin, hesperetin, and resveratrol.
Journal: Mediators of inflammation 20140101
Title: Silibinin as a potential therapeutic for sulfur mustard injuries.
Journal: Chemico-biological interactions 20131205
Title: Silymarin- and melatonin-mediated changes in the expression of selected genes in pesticides-induced Parkinsonism.
Journal: Molecular and cellular biochemistry 20131201
Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: Silibinin inhibits hepatitis C virus entry into hepatocytes by hindering clathrin-dependent trafficking.
Journal: Cellular microbiology 20131101
Title: Silymarin protects from varicocele-induced damages in testis and improves sperm quality: evidence for E2f1 involvement.
Journal: Systems biology in reproductive medicine 20131001
Title: Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats.
Journal: Toxicology letters 20130523
Title: Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130301
Title: Effects of monascin on anti-inflammation mediated by Nrf2 activation in advanced glycation end product-treated THP-1 monocytes and methylglyoxal-treated wistar rats.
Journal: Journal of agricultural and food chemistry 20130213
Title: Biochemical and molecular mechanisms of N-acetyl cysteine and silymarin-mediated protection against maneb- and paraquat-induced hepatotoxicity in rats.
Journal: Chemico-biological interactions 20130125
Title: Silibinin (Milk Thistle) potentiates ethanol-dependent hepatocellular carcinoma progression in male mice.
Journal: Cancer letters 20121229
Title: Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of β1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.
Journal: Medical oncology (Northwood, London, England) 20121201
Title: CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation.
Journal: Journal of cellular biochemistry 20121201
Title: Silibinin inhibits Wnt/β-catenin signaling by suppressing Wnt co-receptor LRP6 expression in human prostate and breast cancer cells.
Journal: Cellular signalling 20121201
Title: Silibinin ameliorates arsenic induced nephrotoxicity by abrogation of oxidative stress, inflammation and apoptosis in rats.
Journal: Molecular biology reports 20121201
Title: Nitric oxide (•NO) generation but not ROS plays a major role in silibinin-induced autophagic and apoptotic death in human epidermoid carcinoma A431 cells.
Journal: Free radical research 20121101
Title: Silibinin for cyclopeptide mushroom poisonings.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20121101
Title: Protection by silibinin against experimental ischemic stroke: up-regulated pAkt, pmTOR, HIF-1α and Bcl-2, down-regulated Bax, NF-κB expression.
Journal: Neuroscience letters 20121031
Title: Silibinin attenuates allergic airway inflammation in mice.
Journal: Biochemical and biophysical research communications 20121026
Title: Silibinin modulates TNF-α and IFN-γ mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells.
Journal: Molecular carcinogenesis 20121001
Title: Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries.
Journal: Toxicology and applied pharmacology 20121001
Title: In vivo evaluation of silybin nanosuspensions targeting liver.
Journal: Journal of biomedical nanotechnology 20121001
Title: Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells.
Journal: Epigenetics 20121001
Title: Hepatoprotective and anti-inflammatory effects of silibinin on experimental preeclampsia induced by L-NAME in rats.
Journal: Life sciences 20120904
Title: Silibinin regulates gene expression, production and secretion of mucin from cultured airway epithelial cells.
Journal: Phytotherapy research : PTR 20120901
Title: Long-term administration of Silymarin augments proinflammatory mediators in the hippocampus of rats: evidence for antioxidant and pro-oxidant effects.
Journal: Human & experimental toxicology 20120901
Title: P53-mediated GSH depletion enhanced the cytotoxicity of NO in silibinin-treated human cervical carcinoma HeLa cells.
Journal: Free radical research 20120901
Title: Mulberry water extracts (MWEs) ameliorated carbon tetrachloride-induced liver damages in rat.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901
Title: Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901
Title: Therapeutic efficacy of silibinin on human neuroblastoma cells: Akt and NF-κB expressions may play an important role in silibinin-induced response.
Journal: Neurochemical research 20120901
Title: Silibinin, a natural flavonoid, modulates the early expression of chemoprevention biomarkers in a preclinical model of colon carcinogenesis.
Journal: International journal of oncology 20120901
Title: Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway.
Journal: Oncology reports 20120901
Title: Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women.
Journal: Journal of reproductive immunology 20120901
Title: Protective effect of curcumin, silymarin and N-acetylcysteine on antitubercular drug-induced hepatotoxicity assessed in an in vitro model.
Journal: Human & experimental toxicology 20120801
Title: The flavonolignan silibinin potentiates TRAIL-induced apoptosis in human colon adenocarcinoma and in derived TRAIL-resistant metastatic cells.
Journal: Apoptosis : an international journal on programmed cell death 20120801
Title: Novel antiosteoclastogenic activity of phloretin antagonizing RANKL-induced osteoclast differentiation of murine macrophages.
Journal: Molecular nutrition & food research 20120801
Title: Hepatitis C therapy in non-genotype 1 patients: the near future.
Journal: Journal of viral hepatitis 20120801
Title: High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy.
Journal: Journal of viral hepatitis 20120801
Title: Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models.
Journal: Surgical endoscopy 20120701
Title: In vitro determination of anticryptosporidial activity of phytogenic extracts and compounds.
Journal: Parasitology research 20120701
Title: Injectable and biodegradable poly(organophosphazene) gel containing silibinin: its physicochemical properties and anticancer activity.
Journal: Journal of pharmaceutical sciences 20120701
Title: Silibinin inhibits tumor growth in a murine orthotopic hepatocarcinoma model and activates the TRAIL apoptotic signaling pathway.
Journal: Anticancer research 20120701
Title: Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
Journal: Journal of medicinal chemistry 20120614
Title: Antiplasmodial activity of flavonol quercetin and its analogues in Plasmodium falciparum: evidence from clinical isolates in Bangladesh and standardized parasite clones.
Journal: Parasitology research 20120601
Title: Complementary and alternative medicines in prostate cancer: from bench to bedside?
Journal: The oncologist 20120601
Title: Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis.
Journal: Translational research : the journal of laboratory and clinical medicine 20120601
Title: Silibinin suppresses the maintenance of colorectal cancer stem-like cells by inhibiting PP2A/AKT/mTOR pathways.
Journal: Journal of cellular biochemistry 20120501
Title: Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats.
Journal: Toxicology mechanisms and methods 20120501
Title: Understanding silibinin's modes of action against HCV using viral kinetic modeling.
Journal: Journal of hepatology 20120501
Title: Identification of novel mechanisms of silymarin on the carbon tetrachloride-induced liver fibrosis in mice by nuclear factor-κB bioluminescent imaging-guided transcriptomic analysis.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: [Acute hepatic failure after ingestion of mushrooms].
Journal: Der Internist 20120501
Title: Cellular and molecular mechanisms of silibinin induces cell-cycle arrest and apoptosis on HeLa cells.
Journal: Cell biochemistry and function 20120401
Title: Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20120401
Title: Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.
Journal: Biochemical and biophysical research communications 20120316
Title: Improvement of cerebellum redox states and cholinergic functions contribute to the beneficial effects of silymarin against manganese-induced neurotoxicity.
Journal: Neurochemical research 20120301
Title: Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner.
Journal: Carcinogenesis 20120301
Title: P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.
Journal: Free radical research 20120301
Title: Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin.
Journal: The journal of pain : official journal of the American Pain Society 20120301
Title: Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line.
Journal: Neurochemical research 20120201
Title: Metabolic effects of silibinin in the rat liver.
Journal: Chemico-biological interactions 20120125
Title: Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats.
Journal: European journal of pharmacology 20120115
Title: Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts.
Journal: Journal of cellular biochemistry 20120101
Title: Synergistic antibacterial effect between silibinin and antibiotics in oral bacteria.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Silibinin is a potent sensitizer of UVA radiation-induced oxidative stress and apoptosis in human keratinocyte HaCaT cells.
Journal: Photochemistry and photobiology 20120101
Title: In vitro release and in vitro-in vivo correlation for silybin meglumine incorporated into hollow-type mesoporous silica nanoparticles.
Journal: International journal of nanomedicine 20120101
Title: In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell.
Journal: Journal of Asian natural products research 20120101
Title: Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats.
Journal: PloS one 20120101
Title: Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling.
Journal: PloS one 20120101
Title: Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation.
Journal: Journal of Asian natural products research 20120101
Title: Metabolic acidosis during treatment of mushroom poisoning: a diagnostic pitfall.
Journal: Internal medicine (Tokyo, Japan) 20120101
Title: Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation.
Journal: PloS one 20120101
Title: Silibinin attenuates sulfur mustard analog-induced skin injury by targeting multiple pathways connecting oxidative stress and inflammation.
Journal: PloS one 20120101
Title: The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis.
Journal: Fundamental & clinical pharmacology 20111201
Title: Synergistic effects between silibinin and antibiotics on methicillin-resistant Staphylococcus aureus isolated from clinical specimens.
Journal: Biotechnology journal 20111101
Title: Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells.
Journal: Free radical research 20111101
Title: Silibinin suppresses EGFR ligand-induced CD44 expression through inhibition of EGFR activity in breast cancer cells.
Journal: Anticancer research 20111101
Title: Neuroprotective effect of silibinin in diabetic mice.
Journal: Neuroscience letters 20111031
Title: The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats.
Journal: Molecules (Basel, Switzerland) 20111012
Title: Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel.
Journal: Molecular carcinogenesis 20111001
Title: Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways.
Journal: European journal of pharmacology 20111001
Title: Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells.
Journal: Apoptosis : an international journal on programmed cell death 20111001
Title: The cytotoxicity of OPA-modified CdSe/ZnS core/shell quantum dots and its modulation by silibinin in human skin cells.
Journal: Journal of biomedical nanotechnology 20111001
Title: Improvement of brain energy metabolism and cholinergic functions contributes to the beneficial effects of silibinin against streptozotocin induced memory impairment.
Journal: Behavioural brain research 20110801
Title: Silibinin mode of action against hepatitis C virus: a controversy yet to be resolved.
Journal: Hepatology (Baltimore, Md.) 20110801
Title: Role of E-cadherin in antimigratory and antiinvasive efficacy of silibinin in prostate cancer cells.
Journal: Cancer prevention research (Philadelphia, Pa.) 20110801
Title: Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells.
Journal: Free radical research 20110701
Title: Effect of silybin on high-fat-induced fatty liver in rats.
Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20110701
Title: Identification and initial SAR of silybin: an Hsp90 inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501
Title: Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis.
Journal: Toxicology and applied pharmacology 20110415
Title: Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice.
Journal: Carcinogenesis 20110401
Title: Silybin inhibits interleukin-1β-induced production of pro-inflammatory mediators in canine hepatocyte cultures.
Journal: Journal of veterinary pharmacology and therapeutics 20110401
Title: Antioxidant, DNA cleavage, and cellular effects of silibinin and a new oxovanadium(IV)/silibinin complex.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20110401
Title: Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Journal: Journal of pineal research 20110301
Title: Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence.
Journal: Pharmacology, biochemistry, and behavior 20110301
Title: Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins.
Journal: Journal of cellular biochemistry 20110301
Title: Silibinin prevents lung tumorigenesis in wild-type but not in iNOS-/- mice: potential of real-time micro-CT in lung cancer chemoprevention studies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110215
Title: Hepatoprotective activity of berberine is mediated by inhibition of TNF-α, COX-2, and iNOS expression in CCl(4)-intoxicated mice.
Journal: Toxicology 20110204
Title: Silibinin: a novel inhibitor of Aβ aggregation.
Journal: Neurochemistry international 20110201
Title: Preparation and effects of 2,3-dehydrosilymarin, a promising and potent antioxidant and free radical scavenger.
Journal: The Journal of pharmacy and pharmacology 20110201
Title: Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle.
Journal: Toxicologic pathology 20110201
Title: Treatment of hepatitis C-virus-reinfection after liver transplant with silibinin in nonresponders to pegylated interferon-based therapy.
Journal: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20110201
Title: Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.
Journal: European journal of pharmacology 20110110
Title: Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin.
Journal: Human & experimental toxicology 20110101
Title: Silibinin-induced apoptosis in MCF7 and T47D human breast carcinoma cells involves caspase-8 activation and mitochondrial pathway.
Journal: Cancer investigation 20110101
Title: Silibinin activated p53 and induced autophagic death in human fibrosarcoma HT1080 cells via reactive oxygen species-p38 and c-Jun N-terminal kinase pathways.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Chemopreventive and chemotherapeutic effects of intravesical silibinin against bladder cancer by acting on mitochondria.
Journal: Molecular cancer therapeutics 20110101
Title: Silibinin activated ROS-p38-NF-κB positive feedback and induced autophagic death in human fibrosarcoma HT1080 cells.
Journal: Journal of Asian natural products research 20110101
Title: Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation.
Journal: PloS one 20110101
Title: Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death.
Journal: Journal of experimental & clinical cancer research : CR 20110101
Title: Prospective randomized clinical trial assessing the efficacy of Denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs.
Journal: Journal of veterinary internal medicine 20110101
Title: Effect of silibinin on endothelial dysfunction and ADMA levels in obese diabetic mice.
Journal: Cardiovascular diabetology 20110101
Title: Natural antioxidants and vascular calcification: a possible benefit.
Journal: Journal of nephrology 20110101
Title: Silibinin causes apoptosis and cell cycle arrest in some human pancreatic cancer cells.
Journal: International journal of molecular sciences 20110101
Title: [Some issues of death cap (Amanita phalloides) poisoning based on cases treated in Poznan Department of Toxicology in 2010].
Journal: Przeglad lekarski 20110101
Title: Intravenous silibinin as 'rescue treatment' for on-treatment non-responders to pegylated interferon/ribavirin combination therapy.
Journal: Antiviral therapy 20110101
Title: [Hepatoprotectors in therapy of the alcoholic liver disease (clinical and experimental research)].
Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101
Title: Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in D-GalN/LPS induced acute liver failure in murine models.
Journal: Chemico-biological interactions 20101205
Title: Natural antioxidants synergistically enhance the anticancer potential of AP9-cd, a novel lignan composition from Cedrus deodara in human leukemia HL-60 cells.
Journal: Chemico-biological interactions 20101205
Title: Silymarin, a natural antioxidant, protects cerebral cortex against manganese-induced neurotoxicity in adult rats.
Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20101201
Title: Alginate-based ferrofluid and magnetic microsphere thereof.
Journal: International journal of biological macromolecules 20101201
Title: Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation.
Journal: Molecular cancer therapeutics 20101201
Title: Inhibition of Cot1/Tlp2 oncogene in AML cells reduces ERK5 activation and up-regulates p27Kip1 concomitant with enhancement of differentiation and cell cycle arrest induced by silibinin and 1,25-dihydroxyvitamin D(3).
Journal: Cell cycle (Georgetown, Tex.) 20101115
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes.
Journal: Natural product research 20101101
Title: Milk thistle in liver diseases: past, present, future.
Journal: Phytotherapy research : PTR 20101001
Title: Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules.
Journal: Pharmaceutical research 20101001
Title: Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20101001
Title: Oral supplementation of silibinin prevents colon carcinogenesis in a long term preclinical model.
Journal: European journal of pharmacology 20100915
Title: Inhibitory effect of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100915
Title: Silibinin can induce differentiation as well as enhance vitamin D3-induced differentiation of human AML cells ex vivo and regulates the levels of differentiation-related transcription factors.
Journal: Hematological oncology 20100901
Title: Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study.
Journal: Toxicology and applied pharmacology 20100901
Title: Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer.
Journal: Cancer metastasis reviews 20100901
Title: Tumor suppressor p53 status does not determine the differentiation-associated G₁ cell cycle arrest induced in leukemia cells by 1,25-dihydroxyvitamin D₃ and antioxidants.
Journal: Cancer biology & therapy 20100815
Title: Silibinin attenuates cardiac hypertrophy and fibrosis through blocking EGFR-dependent signaling.
Journal: Journal of cellular biochemistry 20100801
Title: Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells.
Journal: Nutrition and cancer 20100801
Title: Benzylpenicillin, acetylcysteine and silibinin as antidotes in human hepatocytes intoxicated with alpha-amanitin.
Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20100701
Title: Effects of silybinin, CYP3A4 and P-glycoprotein inhibitor in vitro, on the bioavailability of loratadine in rats.
Journal: Die Pharmazie 20100701
Title: Protective effects of silybin and analogues against X-ray radiation-induced damage.
Journal: Acta biochimica et biophysica Sinica 20100701
Title: Amatoxin poisoning treatment decision-making: pharmaco-therapeutic clinical strategy assessment using multidimensional multivariate statistic analysis.
Journal: Toxicon : official journal of the International Society on Toxinology 20100615
Title: Downregulation of nuclear factor-kappa B (NF-kappaB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis.
Journal: Life sciences 20100605
Title: Silibinin ameliorates oxidative stress induced aberrant crypt foci and lipid peroxidation in 1, 2 dimethylhydrazine induced rat colon cancer.
Journal: Investigational new drugs 20100601
Title: A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancer.
Journal: The Prostate 20100601
Title: Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver.
Journal: Toxicology and applied pharmacology 20100601
Title: Involvement of multiple molecular events in pyrogallol-induced hepatotoxicity and silymarin-mediated protection: evidence from gene expression profiles.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601
Title: Silibinin reverses epithelial-to-mesenchymal transition in metastatic prostate cancer cells by targeting transcription factors.
Journal: Oncology reports 20100601
Title: Multiple effects of silymarin on the hepatitis C virus lifecycle.
Journal: Hepatology (Baltimore, Md.) 20100601
Title: Enhancement of oral bioavailability of the poorly water-soluble drug silybin by sodium cholate/phospholipid-mixed micelles.
Journal: Acta pharmacologica Sinica 20100601
Title: Preparation and in vitro evaluation of povidone-sodium cholate-phospholipid mixed micelles for the solubilization of poorly soluble drugs.
Journal: Archives of pharmacal research 20100601
Title: Preparation and evaluation of galactosylated vesicular carrier for hepatic targeting of silibinin.
Journal: Drug development and industrial pharmacy 20100501
Title: Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.
Journal: Cancer letters 20100501
Title: Evaluation of the genotoxic and anti-genotoxic activities of silybin in human hepatoma cells (HepG2).
Journal: Mutagenesis 20100501
Title: Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy.
Journal: Medical hypotheses 20100501
Title: Establishment of a methodology for investigating protectants against ethanol-induced hepatotoxicity.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100501
Title: Silibinin induces the generation of nitric oxide in human breast cancer MCF-7 cells.
Journal: Free radical research 20100501
Title: Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling.
Journal: Neoplasia (New York, N.Y.) 20100501
Title: [Protective effect of silibinin on liver injury induced by antituberculosis drugs].
Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20100501
Title: [An updated review at molecular pharmacological level for the mechanism of anti-tumor, antioxidant and immunoregulatory action of silibinin].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100401
Title: Identification of hepatoprotective flavonolignans from silymarin.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20100330
Title: Chemoprevention of intestinal tumorigenesis in APCmin/+ mice by silibinin.
Journal: Cancer research 20100315
Title: Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment.
Journal: Behavioural brain research 20100305
Title: Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100301
Title: Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators.
Journal: Molecular carcinogenesis 20100301
Title: Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation.
Journal: Carcinogenesis 20100301
Title: Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Journal: Gastroenterology 20100301
Title: A silybin-phospholipid complex prevents mitochondrial dysfunction in a rodent model of nonalcoholic steatohepatitis.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Silibinin--a promising new treatment for cancer.
Journal: Anti-cancer agents in medicinal chemistry 20100301
Title: Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9.
Journal: Anti-cancer drugs 20100301
Title: Targeting silibinin in the antiproliferative pathway.
Journal: Expert opinion on investigational drugs 20100201
Title: Glycine pretreatment ameliorates liver injury after partial hepatectomy in the rat.
Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20100201
Title: Radioprotection of plasmid and cellular DNA and Swiss mice by silibinin.
Journal: Mutation research 20100101
Title: Silibinin induces protective superoxide generation in human breast cancer MCF-7 cells.
Journal: Free radical research 20100101
Title: Effects of silybinin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen in rats.
Journal: Anticancer research 20100101
Title: Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway.
Journal: Journal of pharmacological sciences 20100101
Title: Effects of silibinin, inhibitor of CYP3A4 and P-glycoprotein in vitro, on the pharmacokinetics of paclitaxel after oral and intravenous administration in rats.
Journal: Pharmacology 20100101
Title: Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats.
Journal: Chemico-biological interactions 20091210
Title: Silibinin inhibits expression of HIF-1alpha through suppression of protein translation in prostate cancer cells.
Journal: Biochemical and biophysical research communications 20091204
Title: Silibinin suppresses spontaneous tumorigenesis in APC min/+ mouse model by modulating beta-catenin pathway.
Journal: Pharmaceutical research 20091201
Title: Self-assembly and characterization of Pluronic P105 micelles for liver-targeted delivery of silybin.
Journal: Journal of drug targeting 20091201
Title: Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells.
Journal: Journal of ethnopharmacology 20091112
Title: Silibinin suppresses TNF-alpha-induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway.
Journal: Molecules (Basel, Switzerland) 20091026
Title: Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20091001
Title: The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells.
Journal: Journal of pharmacological sciences 20091001
Title: Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum.
Journal: Cell biology international 20090901
Title: Silibinin modulates biotransforming microbial enzymes and prevents 1,2-dimethylhydrazine-induced preneoplastic changes in experimental colon cancer.
Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20090901
Title: Preparation of C-23 esterified silybin derivatives and evaluation of their lipid peroxidation inhibitory and DNA protective properties.
Journal: Bioorganic & medicinal chemistry 20090901
Title: Free radical scavenging reactions and antioxidant activities of silybin: mechanistic aspects and pulse radiolytic studies.
Journal: Free radical research 20090901
Title: Silibinin inhibits osteoclast differentiation mediated by TNF family members.
Journal: Molecules and cells 20090901
Title: Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo.
Journal: Neurochemical research 20090801
Title: Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.
Journal: British journal of pharmacology 20090801
Title: Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression.
Journal: Acta pharmacologica Sinica 20090801
Title: Silibinin suppresses growth and induces apoptotic death of human colorectal carcinoma LoVo cells in culture and tumor xenograft.
Journal: Molecular cancer therapeutics 20090801
Title: Micronization of silybin by the emulsion solvent diffusion method.
Journal: International journal of pharmaceutics 20090706
Title: Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum.
Journal: Journal of applied toxicology : JAT 20090701
Title: Rapid suppression of hepatitis C viremia induced by intravenous silibinin plus ribavirin.
Journal: Gastroenterology 20090701
Title: Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090601
Title: Silibinin inhibits translation initiation: implications for anticancer therapy.
Journal: Molecular cancer therapeutics 20090601
Title: The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar rats offspring.
Journal: Journal of Asian natural products research 20090601
Title: Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis.
Journal: Chemico-biological interactions 20090515
Title: Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
Journal: International journal of molecular medicine 20090501
Title: Silibinin feeding alters the metabolic profile in TRAMP prostatic tumors: 1H-NMRS-based metabolomics study.
Journal: Cancer research 20090501
Title: Silibinin attenuates mast cell-mediated anaphylaxis-like reactions.
Journal: Biological & pharmaceutical bulletin 20090501
Title: Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice.
Journal: World journal of gastroenterology 20090428
Title: Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells.
Journal: Molecular nutrition & food research 20090401
Title: Inhibition studies of bovine xanthine oxidase by luteolin, silibinin, quercetin, and curcumin.
Journal: Journal of natural products 20090401
Title: Chemopreventive action of Lygodium flexuosum extract in human hepatoma PLC/PRF/5 and Hep 3B cells.
Journal: Journal of ethnopharmacology 20090318
Title: AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids.
Journal: Chemico-biological interactions 20090316
Title: Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20090301
Title: Effects of resveratrol pretreatment on tert-butylhydroperoxide induced hepatocyte toxicity in immobilized perifused hepatocytes: involvement of inducible nitric oxide synthase and hemoxygenase-1.
Journal: Nitric oxide : biology and chemistry 20090201
Title: Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy.
Journal: Oncogene 20090122
Title: Silibinin suppresses growth of human prostate carcinoma PC-3 orthotopic xenograft via activation of extracellular signal-regulated kinase 1/2 and inhibition of signal transducers and activators of transcription signaling.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090115
Title: Assessment of oxidative stress in leukocytes and granulocyte function following oral administration of a silibinin-phosphatidylcholine complex in cats.
Journal: American journal of veterinary research 20090101
Title: Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3.
Journal: Cancer prevention research (Philadelphia, Pa.) 20090101
Title: Failure of benzylpenicillin, N-acetylcysteine and silibinin to reduce alpha-amanitin hepatotoxicity.
Journal: In vivo (Athens, Greece) 20090101
Title: Pharmacokinetic interaction between oltipraz and silymarin in rats.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101
Title: Optimisation of enzyme assisted extraction of silybin from the seeds of Silybum marianum by Box-Behnken experimental design.
Journal: Phytochemical analysis : PCA 20090101
Title: Cosmeceuticals and silibinin.
Journal: Clinics in dermatology 20090101
Title: Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.
Journal: International journal of cancer 20081215
Title: Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma.
Journal: Cancer letters 20081208
Title: Medicinal flowers. XXIV. Chemical structures and hepatoprotective effects of constituents from flowers of Hedychium coronarium.
Journal: Chemical & pharmaceutical bulletin 20081201
Title: The challenge of herbal therapies for prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081201
Title: Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.
Journal: Gastroenterology 20081101
Title: Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines.
Journal: Phytotherapy research : PTR 20081101
Title: Treatment with silybin-vitamin E-phospholipid complex in patients with hepatitis C infection.
Journal: Journal of medical virology 20081101
Title: Fast repair activities towards dGMP hydroxyl radical adducts by silybin and its analogues.
Journal: Journal of radiation research 20081101
Title: [Amanita poisoning--comparison of silibinin with a combination of silibinin and penicillin].
Journal: Deutsche medizinische Wochenschrift (1946) 20081001
Title: Interspecies comparison of the glucuronidation processes in the man, monkey, pig, dog and rat.
Journal: Neuro endocrinology letters 20081001
Title: Cell growth inhibition and down-regulation of survivin by silibinin in a laryngeal squamous cell carcinoma cell line.
Journal: The Annals of otology, rhinology, and laryngology 20081001
Title: Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats.
Journal: Cancer prevention research (Philadelphia, Pa.) 20081001
Title: Effects of silibinin on cell growth and invasive properties of a human hepatocellular carcinoma cell line, HepG-2, through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation.
Journal: European journal of pharmacology 20080904
Title: Silibinin impairs constitutively active TGFalpha-EGFR autocrine loop in advanced human prostate carcinoma cells.
Journal: Pharmaceutical research 20080901
Title: Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.
Journal: Cancer research 20080815
Title: Evaluation of silibinin on the viability, migration and adhesion of the human prostate adenocarcinoma (PC-3) cell line.
Journal: Cell biology international 20080801
Title: Synergistic antibacterial effect between silybin and N,N'-dicyclohexylcarbodiimide in clinical Pseudomonas aeruginosa isolates.
Journal: Journal of microbiology (Seoul, Korea) 20080801
Title: The effect of an iron (III) chelator, silybin, on the proliferation and cell cycle of Jurkat cells: a comparison with desferrioxamine.
Journal: European journal of pharmacology 20080728
Title: Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.
Journal: Cancer chemotherapy and pharmacology 20080701
Title: Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.
Journal: International journal of cancer 20080701
Title: Silymarin prevents adriamycin-induced cardiotoxicity and nephrotoxicity in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701
Title: Inhibitory mechanisms of flavonoids on insulin-stimulated glucose uptake in MC3T3-G2/PA6 adipose cells.
Journal: Biological & pharmaceutical bulletin 20080701
Title: Inhibition of insulin-like growth factor 1 receptor signaling enhanced silibinin-induced activation of death receptor and mitochondrial apoptotic pathways in human breast cancer MCF-7 cells.
Journal: Journal of pharmacological sciences 20080701
Title: Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells.
Journal: Molecular cancer therapeutics 20080701
Title: Interrelation between the inhibition of glycolytic flux by silibinin and the lowering of mitochondrial ROS production in perifused rat hepatocytes.
Journal: Life sciences 20080523
Title: Significantly greater antioxidant anticancer activities of 2,3-dehydrosilybin than silybin.
Journal: Biochimica et biophysica acta 20080501
Title: Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.
Journal: European journal of cancer (Oxford, England : 1990) 20080401
Title: Silibinin inhibits colorectal cancer growth by inhibiting tumor cell proliferation and angiogenesis.
Journal: Cancer research 20080315
Title: Hepatobiliary excretion of silibinin in normal and liver cirrhotic rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080301
Title: Antioxidant and mitochondrial protective effects of silibinin in cold preservation-warm reperfusion liver injury.
Journal: Journal of ethnopharmacology 20080212
Title: Mechanism of the antioxidant action of silybin and 2,3-dehydrosilybin flavonolignans: a joint experimental and theoretical study.
Journal: The journal of physical chemistry. A 20080207
Title: Preparative chromatographic purification of diastereomers of silybin and their quantification in human plasma by liquid chromatography-tandem mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201
Title: In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating.
Journal: Planta medica 20080201
Title: Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats.
Journal: Phytotherapy research : PTR 20080101
Title: Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080101
Title: Preparation and properties of a silybin-phospholipid complex.
Journal: Die Pharmazie 20080101
Title: Hepatoprotective effect of Cirsium arisanense Kitamura in tacrine-treated hepatoma Hep 3B cells and C57BL mice.
Journal: The American journal of Chinese medicine 20080101
Title: Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells.
Journal: Anticancer research 20080101
Title: Silibinin suppresses in vivo growth of human prostate carcinoma PC-3 tumor xenograft.
Journal: Carcinogenesis 20071201
Title: Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice.
Journal: Molecular cancer therapeutics 20071201
Title: Vinpocetine ameliorates acute hepatic damage caused by administration of carbon tetrachloride in rats.
Journal: Acta biologica Hungarica 20071201
Title: Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application.
Journal: Journal of pharmaceutical and biomedical analysis 20071130
Title: Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model.
Journal: Cancer research 20071115
Title: Silybin is metabolized by cytochrome P450 2C8 in vitro.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101
Title: Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer.
Journal: The Journal of surgical research 20071101
Title: Inhibition effect of flavonoids on monocarboxylate transporter 1 (MCT1) in Caco-2 cells.
Journal: The Journal of pharmacy and pharmacology 20071101
Title: Effects and mechanisms of silibinin on human hepatoma cell lines.
Journal: World journal of gastroenterology 20071028
Title: Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice.
Journal: Environmental toxicology 20071001
Title: p21 and p27 induction by silibinin is essential for its cell cycle arrest effect in prostate carcinoma cells.
Journal: Molecular cancer therapeutics 20071001
Title: Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis.
Journal: Archives of pharmacal research 20071001
Title: Effect of silibinin on the pharmacokinetics of pyrazinamide and pyrazinoic acid in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070901
Title: Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
Journal: Annals of emergency medicine 20070901
Title: Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents: efficacy and mechanisms.
Journal: Acta pharmacologica Sinica 20070901
Title: Effects of silibinin hemisuccinate on the intraocular pressure in normotensive rabbits.
Journal: Saudi medical journal 20070901
Title: Silibinin sensitizes human glioma cells to TRAIL-mediated apoptosis via DR5 up-regulation and down-regulation of c-FLIP and survivin.
Journal: Cancer research 20070901
Title: Renal and hepatic injury with elevated cardiac enzymes in Amanita phalloides poisoning: a case report.
Journal: Human & experimental toxicology 20070901
Title: Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride.
Journal: Molecular and cellular biochemistry 20070801
Title: Therapeutic value of orally administered silibinin in renal cell carcinoma: manipulation of insulin-like growth factor binding protein-3 levels.
Journal: BJU international 20070801
Title: Protective effects of Cuscutae semen against dimethylnitrosamine-induced acute liver injury in Sprague-Dawley rats.
Journal: Biological & pharmaceutical bulletin 20070801
Title: Preparation and characterization of solid lipid nanoparticles containing silibinin.
Journal: Drug delivery 20070801
Title: Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells.
Journal: Carcinogenesis 20070701
Title: Iron chelation or anti-oxidants prevent renal cell damage in the rewarming phase after normoxic, but not hypoxic cold incubation.
Journal: Cryobiology 20070601
Title: Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent.
Journal: Acta pharmacologica Sinica 20070601
Title: Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy.
Journal: Integrative cancer therapies 20070601
Title: Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2.
Journal: Carcinogenesis 20070501
Title: Synchronized and sustained release of multiple components in silymarin from erodible glyceryl monostearate matrix system.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070501
Title: Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells.
Journal: International journal of cancer 20070501
Title: Simultaneous determination of lithospermic acid B and its three metabolites by liquid chromatography/tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20070411
Title: Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites.
Journal: Journal of agricultural and food chemistry 20070404
Title: Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070401
Title: A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients.
Journal: Investigational new drugs 20070401
Title: Silibinin inhibits inflammatory and angiogenic attributes in photocarcinogenesis in SKH-1 hairless mice.
Journal: Cancer research 20070401
Title: [Amatoxin poisoning due to soup from personally picked deathcap mushrooms (Amanita phalloides)].
Journal: Nederlands tijdschrift voor geneeskunde 20070331
Title: Silibinin suppresses PMA-induced MMP-9 expression by blocking the AP-1 activation via MAPK signaling pathways in MCF-7 human breast carcinoma cells.
Journal: Biochemical and biophysical research communications 20070302
Title: [Protective effect of silibinin against isoproterenol-induced injury to cardiac myocytes and its mechanism].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070301
Title: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Journal: Carcinogenesis 20070201
Title: Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells.
Journal: Journal of cellular physiology 20070201
Title: Influence of silybin on biophysical properties of phospholipid bilayers.
Journal: Acta pharmacologica Sinica 20070201
Title: Silibinin inhibits renal cell carcinoma via mechanisms that are independent of insulin-like growth factor-binding protein 3.
Journal: BJU international 20070201
Title: Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis.
Journal: Journal of gastroenterology and hepatology 20070101
Title: Formulation and biopharmaceutical evaluation of silymarin using SMEDDS.
Journal: Archives of pharmacal research 20070101
Title: (+)-Silybin, a pharmacologically active constituent of Silybum marianum: fragmentation studies by atmospheric pressure chemical ionization quadrupole time-of-flight tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: The flavonoid silibinin decreases glucose-6-phosphate hydrolysis in perfused rat hepatocytes by an inhibitory effect on glucose-6-phosphatase.
Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
Title: Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.
Journal: Burns : journal of the International Society for Burn Injuries 20061201
Title: Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1.
Journal: Journal of pharmacological sciences 20061201
Title: Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
Journal: Carcinogenesis 20061101
Title: Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine.
Journal: The Indian journal of medical research 20061101
Title: Silybin reduces lipid peroxidation of rat hepatocyte membrane caused by cyclosporin A.
Journal: Biochemistry. Biokhimiia 20061001
Title: [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats].
Journal: Zhonghua yi xue za zhi 20060926
Title: Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle.
Journal: Biological & pharmaceutical bulletin 20060901
Title: Differential effect of silibinin on E2F transcription factors and associated biological events in chronically UVB-exposed skin versus tumors in SKH-1 hairless mice.
Journal: Molecular cancer therapeutics 20060801
Title: Synthesis and antioxidant evaluation of novel silybin analogues.
Journal: Journal of enzyme inhibition and medicinal chemistry 20060801
Title: Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity.
Journal: Cancer letters 20060708
Title: Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice.
Journal: Molecular cancer therapeutics 20060701
Title: Effect of silibinin on the growth and progression of primary lung tumors in mice.
Journal: Journal of the National Cancer Institute 20060621
Title: Prostate cancer chemoprevention by silibinin: bench to bedside.
Journal: Molecular carcinogenesis 20060601
Title: Antiparasitic activity of flavonoids and isoflavones against Cryptosporidium parvum and Encephalitozoon intestinalis.
Journal: FEMS microbiology letters 20060601
Title: Cadmium-induced apoptosis in murine macrophages is antagonized by antioxidants and caspase inhibitors.
Journal: Journal of toxicology and environmental health. Part A 20060601
Title: Silibinin prevents UV-induced HaCaT cell apoptosis partly through inhibition of caspase-8 pathway.
Journal: Biological & pharmaceutical bulletin 20060601
Title: Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.
Journal: Journal of chromatography. A 20060526
Title: Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.
Journal: Journal of biomedical science 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Pilot study of oral silibinin, a putative chemopreventive agent, in colorectal cancer patients: silibinin levels in plasma, colorectum, and liver and their pharmacodynamic consequences.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060501
Title: Silibinin inhibits UVB- and epidermal growth factor-induced mitogenic and cell survival signaling involving activator protein-1 and nuclear factor-kappaB in mouse epidermal JB6 cells.
Journal: Molecular cancer therapeutics 20060501
Title: Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization.
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060501
Title: MDR- and CYP3A4-mediated drug-herbal interactions.
Journal: Life sciences 20060327
Title: Silibinin inhibits invasion of oral cancer cells by suppressing the MAPK pathway.
Journal: Journal of dental research 20060301
Title: Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.
Journal: Cell biology and toxicology 20060301
Title: Silymarin and silibinin cause G1 and G2-M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin.
Journal: Oncogene 20060216
Title: The preparation of silybin-phospholipid complex and the study on its pharmacokinetics in rats.
Journal: International journal of pharmaceutics 20060103
Title: In vitro antimalarial activity of flavonoid derivatives dehydrosilybin and 8-(1;1)-DMA-kaempferide.
Journal: Acta tropica 20060101
Title: Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20060101
Title: [Oxidative stress in metabolic syndrome and nonalcoholic steatohepatitis. Is it possible a role for vitamins in clinical practice?].
Journal: Recenti progressi in medicina 20060101
Title: Silibinin efficacy against human hepatocellular carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051201
Title: Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Journal: Neoplasia (New York, N.Y.) 20051201
Title: Hepatoprotective constituents of the edible brown alga Ecklonia stolonifera on tacrine-induced cytotoxicity in Hep G2 cells.
Journal: Archives of pharmacal research 20051201
Title: Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation.
Journal: Toxicology 20051105
Title: Hepatoprotective and antifibrotic effect of a new silybin-phosphatidylcholine-Vitamin E complex in rats.
Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20051101
Title: Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways.
Journal: Chemico-biological interactions 20051020
Title: Protective effects of silybin on human umbilical vein endothelial cell injury induced by H2O2 in vitro.
Journal: Vascular pharmacology 20051001
Title: [Progress in research of aldose reductase inhibitors in traditional medicinal herbs].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001
Title: Silibinin inhibits angiogenesis via Flt-1, but not KDR, receptor up-regulation.
Journal: The Journal of surgical research 20050901
Title: Mechanisms and preclinical efficacy of silibinin in preventing skin cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20050901
Title: Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).
Journal: The FEBS journal 20050901
Title: A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos).
Journal: Alternative medicine review : a journal of clinical therapeutic 20050901
Title: Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids.
Journal: Life sciences 20050826
Title: Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin.
Journal: Carcinogenesis 20050801
Title: Iron and iron chelating agents modulate Mycobacterium tuberculosis growth and monocyte-macrophage viability and effector functions.
Journal: FEMS immunology and medical microbiology 20050801
Title: Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050701
Title: [Preparation of silybin-phospholipid complex and its bioavailability in rats].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050701
Title: Inhibition of rat liver UDP-glucuronosyltransferase by silymarin and the metabolite silibinin-glucuronide.
Journal: Life sciences 20050624
Title: Liquid chromatography/tandem mass spectrometry for the determination of magnesium lithospermate B in beagle dog serum.
Journal: Journal of pharmaceutical and biomedical analysis 20050601
Title: [Effects of a new pharmacological complex (silybin + vitamin-E + phospholipids) on some markers of the metabolic syndrome and of liver fibrosis in patients with hepatic steatosis. Preliminary study].
Journal: Minerva gastroenterologica e dietologica 20050601
Title: Silibinin up-regulates DNA-protein kinase-dependent p53 activation to enhance UVB-induced apoptosis in mouse epithelial JB6 cells.
Journal: The Journal of biological chemistry 20050527
Title: Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid.
Journal: Basic & clinical pharmacology & toxicology 20050501
Title: Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050501
Title: Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP.
Journal: Biochemical pharmacology 20050401
Title: Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl(4)-induced hepatic fibrosis.
Journal: World journal of gastroenterology 20050227
Title: Silibinin strongly inhibits growth and survival of human endothelial cells via cell cycle arrest and downregulation of survivin, Akt and NF-kappaB: implications for angioprevention and antiangiogenic therapy.
Journal: Oncogene 20050210
Title: Silymarin induces apoptosis primarily through a p53-dependent pathway involving Bcl-2/Bax, cytochrome c release, and caspase activation.
Journal: Molecular cancer therapeutics 20050201
Title: Potential utility of natural polyphenols for reversing fat-induced insulin resistance.
Journal: Medical hypotheses 20050101
Title: Metal-induced oxidative damage in cultured hepatocytes and hepatic lysosomal fraction: beneficial effect of a curcumin/absinthium compound.
Journal: Chinese journal of digestive diseases 20050101
Title: Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats.
Journal: Journal of biomedical science 20050101
Title: Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes.
Journal: Journal of biochemical and molecular toxicology 20050101
Title: Oral silibinin inhibits lung tumor growth in athymic nude mice and forms a novel chemocombination with doxorubicin targeting nuclear factor kappaB-mediated inducible chemoresistance.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
Title: A cancer chemopreventive agent silibinin, targets mitogenic and survival signaling in prostate cancer.
Journal: Mutation research 20041102
Title: Oxidised derivatives of silybin and their antiradical and antioxidant activity.
Journal: Bioorganic & medicinal chemistry 20041101
Title: Silibinin causes cell cycle arrest and apoptosis in human bladder transitional cell carcinoma cells by regulating CDKI-CDK-cyclin cascade, and caspase 3 and PARP cleavages.
Journal: Carcinogenesis 20040901
Title: Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.
Journal: Cancer research 20040901
Title: Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.
Journal: Carcinogenesis 20040801
Title: Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.
Journal: Molecular carcinogenesis 20040701
Title: Effects of silymarin, a natural hepatoprotector, in periparturient dairy cows.
Journal: Journal of dairy science 20040701
Title: Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601
Title: Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity.
Journal: Pharmacological research 20040501
Title: Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells.
Journal: The Journal of urology 20040501
Title: Silibinin down-regulates prostate epithelium-derived Ets transcription factor in LNCaP prostate cancer cells.
Journal: Planta medica 20040501
Title: Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signaling.
Journal: Toxicology and applied pharmacology 20040401
Title: Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells.
Journal: Oncology reports 20040201
Title: Prostate cancer prevention by silibinin.
Journal: Current cancer drug targets 20040201
Title: Effect of silybin on phorbol myristate actetate-induced protein kinase C translocation, NADPH oxidase activity and apoptosis in human neutrophils.
Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20040201
Title: Dual efficacy of silibinin in protecting or enhancing ultraviolet B radiation-caused apoptosis in HaCaT human immortalized keratinocytes.
Journal: Carcinogenesis 20040101
Title: Involvement of NF-kappaB and caspases in silibinin-induced apoptosis of endothelial cells.
Journal: International journal of molecular medicine 20040101
Title: Silymarin extraction from milk thistle using hot water.
Journal: Applied biochemistry and biotechnology 20040101
Title: Silibinin down-regulates survivin protein and mRNA expression and causes caspases activation and apoptosis in human bladder transitional-cell papilloma RT4 cells.
Journal: Biochemical and biophysical research communications 20031226
Title: Comparative bioavailability of silibinin in healthy male volunteers.
Journal: International journal of clinical pharmacology and therapeutics 20031201
Title: Effects of flavonoids on the resistance of microsomes to lipid peroxidation in vitro and ex vivo.
Journal: Bulletin of experimental biology and medicine 20031201
Title: Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells.
Journal: Oncogene 20031113
Title: [Amanita poisoning during pregnancy].
Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20031101
Title: Antioxidants protect primary rat hepatocyte cultures against acetaminophen-induced DNA strand breaks but not against acetaminophen-induced cytotoxicity.
Journal: Toxicology 20030930
Title: Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- and carboplatin-induced growth inhibition and apoptotic death.
Journal: International journal of cancer 20030920
Title: Application of liquid chromatography-electrospray ionization-ion trap mass spectrometry to investigate the metabolism of silibinin in human liver microsomes.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905
Title: Silibinin protects mice from T cell-dependent liver injury.
Journal: Journal of hepatology 20030901
Title: Suppression of advanced human prostate tumor growth in athymic mice by silibinin feeding is associated with reduced cell proliferation, increased apoptosis, and inhibition of angiogenesis.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20030901
Title: Cytotoxicity of inorganic mercury in murine T and B lymphoma cell lines: involvement of reactive oxygen species, Ca(2+) homeostasis, and cytokine gene expression.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20030801
Title: Gram-positive bacteria specific properties of silybin derived from Silybum marianum.
Journal: Archives of pharmacal research 20030801
Title: Anti-angiogenic effect of silymarin on colon cancer LoVo cell line.
Journal: The Journal of surgical research 20030701
Title: Plasma lipoproteins in transport of silibinin, an antioxidant flavonolignan from Silybum marianum.
Journal: Phytotherapy research : PTR 20030501
Title: Mechanism-based in vitro screening of potential cancer chemopreventive agents.
Journal: Mutation research 20030101
Title: Extraction of nutraceuticals from milk thistle: I. Hot water extraction.
Journal: Applied biochemistry and biotechnology 20030101
Title: [St. Mary's Thistle: an overview].
Journal: Journal de pharmacie de Belgique 20030101
Title: Preparation and pharmacological evaluation of silibinin liposomes.
Journal: Arzneimittel-Forschung 20030101
Title: Silibinin induces growth inhibition and apoptotic cell death in human lung carcinoma cells.
Journal: Anticancer research 20030101
Title: Primary human hepatocytes are protected against prolonged and repeated exposure to ethanol by silibinin-dihemisuccinate.
Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20030101
Title: Epidermal growth factor receptor mediates silibinin-induced cytotoxicity in a rat glioma cell line.
Journal: Cancer biology & therapy 20030101
Title: Silibinin: a thorny therapeutic for EGF-R expressing tumors?
Journal: Cancer biology & therapy 20030101
Title: Antiproliferative and apoptotic effects of silibinin in rat prostate cancer cells.
Journal: The Prostate 20021101
Title: Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.
Journal: Phytotherapy research : PTR 20021101
Title: Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021101
Title: Silybin-beta-cyclodextrin in the treatment of patients with diabetes mellitus and alcoholic liver disease. Efficacy study of a new preparation of an anti-oxidant agent.
Journal: Diabetes, nutrition & metabolism 20020801
Title: Inhibition of retinoblastoma protein (Rb) phosphorylation at serine sites and an increase in Rb-E2F complex formation by silibinin in androgen-dependent human prostate carcinoma LNCaP cells: role in prostate cancer prevention.
Journal: Molecular cancer therapeutics 20020501
Title: Impact of in utero exposure to EtOH on corpus callosum development and paw preference in rats: protective effects of silymarin.
Journal: BMC complementary and alternative medicine 20020101
Title: The cancer preventive flavonoid silibinin causes hypophosphorylation of Rb/p107 and Rb2/p130 via modulation of cell cycle regulators in human prostate carcinoma DU145 cells.
Journal: Cell cycle (Georgetown, Tex.) 20020101
Title: Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.
Journal: Journal of medicinal chemistry 20010118
Title: Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin.
Journal: Carcinogenesis 20000401
Title: Stimulatory effects of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells.
Journal: The Journal of pharmacology and experimental therapeutics 19990901
Title: Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats.
Journal: Hepatology (Baltimore, Md.) 19970901
Title: Inhibition of reverse transcriptases by flavonoids.
Journal: Antiviral research 19890901
Title: [Effectiveness of legalon and essentiale in a tetracycline-induced liver lesion].
Journal: Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology 19861001
Title: Woo SM, et al. Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation. Chem Biol Interact. 2014 Jan 16;211C:36-43.
Title: Kim TH, et al. Silibinin induces cell death through ROS-dependent down-regulation of Notch-1/ERK/Akt signaling in human breast cancer cells. J Pharmacol Exp Ther. 2014 Jan 28.
Title: Zhang S, et al. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One. 2013 Dec 27;8(12):e83699.
Title: Khan AQ, et al. Silibinin Inhibits Tumor Promotional Triggers and Tumorigenesis Against Chemically Induced Two-Stage Skin Carcinogenesis in Swiss Albino Mice: Possible Role of Oxidative Stress and Inflammation. Nutr Cancer. 2013 Dec 23.
Title: Khazim K, et al. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F691-700.
