Catalog No.:AA00C29X

230961-08-7 | N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine

Name: Name:N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
Brand: AABLOCKS
SKU: AA00C29X
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5mg

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25mg

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA00C29X

Chemical Name:

N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine

CAS Number:

230961-08-7

Molecular Formula:

C34H43N3O4

Molecular Weight:

557.7229

MDL Number:

MFCD19443865

SMILES:

ONC(=O)CC(C(=O)NC(C(C)(C)C)C(=O)NC(c1ccccc1)C)CCCc1ccc(c(c1)C)c1ccccc1

Properties

Computed Properties

Complexity:

828

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

6.1

Literature

Title: Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

Journal: Bioorganic & medicinal chemistry 20081001

Title: Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs.

Journal: Bioorganic & medicinal chemistry 20070315

Title: A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.

Journal: Journal of medicinal chemistry 20030731

Title: Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1).

Journal: Bioorganic & medicinal chemistry letters 20010226

Title: Fray MJ, et al. Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg Med Chem Lett. 2001 Feb 26;11(4):571-4.

Title: Yan HQ, et al. Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells. Oncotarget. 2016 Sep 20;7(38):62070-62083.

Title: Hafez S, et al. Matrix Metalloprotease 3 Exacerbates Hemorrhagic Transformation and Worsens Functional Outcomes in Hyperglycemic Stroke. Stroke. 2016 Mar;47(3):843-51.

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