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Home Amines 231278-20-9
231278-20-9,MFCD09998827
Catalog No.:AA002M69

231278-20-9 | N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
98%
in stock  
$6.00   $4.00
- +
1g
98%
in stock  
$7.00   $5.00
- +
5g
98%
in stock  
$9.00   $7.00
- +
25g
98%
in stock  
$42.00   $29.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002M69
Chemical Name:
N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine
CAS Number:
231278-20-9
Molecular Formula:
C21H14ClFIN3O
Molecular Weight:
505.7112
MDL Number:
MFCD09998827
SMILES:
Fc1cccc(c1)COc1ccc(cc1Cl)Nc1ncnc2c1cc(I)cc2
Properties
Properties
 
BP:
581.326 °C at 760 mmHg  
Form:
Solid  
MP:
222-224 °C  
Stability:
Light Sensitive  
Storage:
2-8℃;Light sensitive;  

Computed Properties
 
Complexity:
504  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
6.3  

Downstream Synthesis Route

[1]Roschangar,Frank;Brown,JenniferC;CooleyJr.,BobbyE;Sharp,MatthewJ;Matsuoka,RichardT[Tetrahedron,2002,vol.58,#9,p.1657-1666]

[1]Patent:US2015/366868,2015,A1.Locationinpatent:Paragraph0159

[2]BioorganicandMedicinalChemistry,2017,vol.25,p.27-37

[3]EuropeanJournalofMedicinalChemistry,2017,vol.127,p.442-458

[4]Patent:WO2008/67144,2008,A2.Locationinpatent:Page/Pagecolumn23-24

[5]Patent:CN105085496,2018,B.Locationinpatent:Paragraph0044;0045

[6]Patent:WO2008/33747,2008,A2.Locationinpatent:Page/Pagecolumn169

[7]BioorganicandMedicinalChemistryLetters,2003,vol.13,p.637-640

[8]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4686-4691

[9]Patent:WO2009/63054,2009,A1.Locationinpatent:Page/Pagecolumn69

[10]Patent:WO2005/46678,2005,A1.Locationinpatent:Page/Pagecolumn67-68

[11]Patent:WO2006/26313,2006,A2.Locationinpatent:Page/Pagecolumn23

[12]Patent:WO2006/113649,2006,A1.Locationinpatent:Page/Pagecolumn46

[13]JournalofMedicinalChemistry,2010,vol.53,p.8546-8555

[14]Patent:WO2005/120512,2005,A2.Locationinpatent:Page/Pagecolumn23

[15]Patent:WO2005/120504,2005,A2.Locationinpatent:Page/Pagecolumn30

[16]Patent:WO2007/121279,2007,A2.Locationinpatent:Page/Pagecolumn25;40;41

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2015/366868,2015,A1Locationinpatent:Paragraph0175-0176

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC;KUMAR-WO2005/105094,2005,A2Locationinpatent:Page/Pagecolumn51

[3]Gaul,MichealD.;Guo,Yu;Affleck,Karen;Cockerill,G.Stuart;Gilmer,TonaM.;Griffin,RobertJ.;Guntrip,Stephen;Keith,BarryR.;Knight,WilsonB.;Mullin,RobertJ.;Murray,DorisM.;Rusnak,DavidW.;Smith,Kathryn;Tadepalli,Sarva;Wood,EdgarR.;Lackey,Karen[BioorganicandMedicinalChemistryLetters,2003,vol.13,#4,p.637-640]

[1]Patent:WO2010/17387,2010,A2.Locationinpatent:Page/Pagecolumn24

[2]Patent:CN105503839,2016,A.Locationinpatent:Paragraph0046;0047

[3]Patent:WO2010/61400,2010,A1.Locationinpatent:Page/Pagecolumn15

[4]Patent:US2011/263852,2011,A1.Locationinpatent:Page/Pagecolumn12

[5]Patent:CN109503559,2019,A.Locationinpatent:Paragraph0019

[6]Patent:WO2014/59956,2014,A1.Locationinpatent:Page/Pagecolumn11;12

[7]BioorganicandMedicinalChemistryLetters,2017,vol.27,p.1584-1587

[8]BioorganicandMedicinalChemistryLetters,2017,vol.27,p.4309-4313

[9]JournalofEnzymeInhibitionandMedicinalChemistry,2019,vol.34,p.1668-1677

[10]Patent:WO2009/63054,2009,A1.Locationinpatent:Page/Pagecolumn69-70

[11]JournalofMedicinalChemistry,2010,vol.53,p.8546-8555

[12]ChemCatChem,2020,vol.12,p.2942-2946

[13]Patent:WO2008/33747,2008,A2.Locationinpatent:Page/Pagecolumn169-170

[14]BioorganicandMedicinalChemistryLetters,2006,vol.16,p.4686-4691

[15]Patent:US2003/220354,2003,A1

[16]Patent:WO2011/39759,2011,A1.Locationinpatent:Page/Pagecolumn14

[17]EuropeanJournalofMedicinalChemistry,2013,vol.69,p.833-841

[18]EuropeanJournalofMedicinalChemistry,2014,vol.87,p.631-642

[19]Patent:WO2005/120512,2005,A2.Locationinpatent:Page/Pagecolumn24

[20]Patent:WO2005/120504,2005,A2.Locationinpatent:Page/Pagecolumn31

[21]Patent:WO2007/121279,2007,A2.Locationinpatent:Page/Pagecolumn41

[22]Patent:WO2007/121279,2007,A2.Locationinpatent:Page/Pagecolumn44-45

[23]Patent:WO2005/105094,2005,A2.Locationinpatent:Page/Pagecolumn45

[1]Patent:WO2005/105094,2005,A2.Locationinpatent:Page/Pagecolumn44-45

Literature
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SDS
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