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231957-54-3,MFCD30532549
Catalog No.:AA01E3S6

231957-54-3 | MIV-1R

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$279.00   $195.00
- +
5mg
≥98%
in stock  
$1,082.00   $757.00
- +
10mg
≥98%
in stock  
$1,545.00   $1,081.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E3S6
Chemical Name:
MIV-1R
CAS Number:
231957-54-3
Molecular Formula:
C19H17FN4O3
Molecular Weight:
368.3617
MDL Number:
MFCD30532549
SMILES:
CCC(=O)c1ccc(c(c1O)[C@@H]1C[C@@H]1NC(=O)Nc1ccc(cn1)C#N)F
Properties
Computed Properties
 
Complexity:
621  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
2.3  

Literature

Title: An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.

Journal: Science translational medicine 20120905

Title: An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques.

Journal: PloS one 20110101

Title: Update on microbicide research and development - seeking new HIV prevention tools for women.

Journal: European journal of medical research 20110101

Title: A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy.

Journal: PloS one 20090101

Title: Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis.

Journal: Bioorganic & medicinal chemistry 20071201

Title: N2-benzyloxycarbonylguan-9-yl acetic acid derivatives as HIV-1 reverse transcriptase non-nucleoside inhibitors with decreased loss of potency against common drug-resistance mutations.

Journal: ChemMedChem 20071001

Title: Carrageenan/MIV-150 (PC-815), a combination microbicide.

Journal: Sexually transmitted diseases 20070101

Title: Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors.

Journal: Journal of medicinal chemistry 20060420

Title: Fernández-Romero JA, et al. Carrageenan/MIV-150 (PC-815), a combination microbicide. Sex Transm Dis. 2007 Jan;34(1):9-14.

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SDS
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