Home Amines 23239-88-5
23239-88-5,MFCD00012999
Catalog No.:AA002MK0

23239-88-5 | Benzoic acid, 4-amino-, ethyl ester, hydrochloride (1:1)

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1g
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$84.00   $59.00
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5g
99%
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$122.00   $85.00
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25g
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100g
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002MK0
Chemical Name:
Benzoic acid, 4-amino-, ethyl ester, hydrochloride (1:1)
CAS Number:
23239-88-5
Molecular Formula:
C9H12ClNO2
Molecular Weight:
201.6501
MDL Number:
MFCD00012999
SMILES:
CCOC(=O)c1ccc(cc1)N.Cl
NSC Number:
122792
Properties
Computed Properties
 
Complexity:
151  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Literature

Title: Relief of palatal injection pain by liposome-encapsulated 2% lignocaine prepared by ultrasonic dental scaler.

Journal: The British journal of oral & maxillofacial surgery 20121201

Title: The in vitro and in vivo genotoxicity of benzocaine: a brief communication.

Journal: International journal of toxicology 20120601

Title: Hydrophilic interaction liquid chromatography of anthranilic acid-labelled oligosaccharides with a 4-aminobenzoic acid ethyl ester-labelled dextran hydrolysate internal standard.

Journal: Journal of chromatography. A 20120413

Title: Modification of crystallization behavior in drug/polyethylene glycol solid dispersions.

Journal: Molecular pharmaceutics 20120305

Title: Methemoglobinemia in postchemotherapy stomatitis topical treatment: 2 pediatric cases.

Journal: Journal of pediatric hematology/oncology 20120301

Title: Benzocaine-loaded polymeric nanocapsules: study of the anesthetic activities.

Journal: Journal of pharmaceutical sciences 20120301

Title: Efficacy of a benzocaine lozenge in the treatment of uncomplicated sore throat.

Journal: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20120201

Title: Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben.

Journal: Neuroscience letters 20120111

Title: Role of viscosity in influencing the glass-forming ability of organic molecules from the undercooled melt state.

Journal: Pharmaceutical research 20120101

Title: Clinical efficacy of tetracaine anesthetic paste.

Journal: General dentistry 20120101

Title: Determination of local anesthetics in illegal products using HPLC method with amperometric detection.

Journal: Acta poloniae pharmaceutica 20120101

Title: Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression.

Journal: Bioorganic & medicinal chemistry letters 20111215

Title: Severe methemoglobinaemia due to benzocaine-containing 'burn cream': two case reports in an adult and in a child.

Journal: Burns : journal of the International Society for Burn Injuries 20111101

Title: Investigation on the pH-dependent binding of benzocaine and lysozyme by fluorescence and absorbance.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101

Title: Thermodynamic study of benzocaine insertion into different lipid bilayers.

Journal: The Journal of chemical physics 20111007

Title: Benzocaine-induced methemoglobinemia in an acute-exposure rat model.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111001

Title: Prevalence of benzocaine and lidocaine patch test sensitivity in Denmark: temporal trends and relevance.

Journal: Contact dermatitis 20110801

Title: Poly(lactide-co-glycolide) nanocapsules containing benzocaine: influence of the composition of the oily nucleus on physico-chemical properties and anesthetic activity.

Journal: Pharmaceutical research 20110801

Title: Euthanization methods influence cytokine mRNA expression levels in age 0 year Oncorhynchus mykiss.

Journal: Journal of fish biology 20110801

Title: Since Katrina: neonatal and pediatric issues from both sides of the levee.

Journal: Pediatrics 20110801

Title: Five years of changes on the receiving end of a disaster.

Journal: Pediatrics 20110801

Title: Katrina changed us (and me) in so many ways.

Journal: Pediatrics 20110801

Title: My life with hurricanes.

Journal: Pediatrics 20110801

Title: Resilience challenged: thoughts on children's mental health in the Gulf Coast 5 years after Katrina.

Journal: Pediatrics 20110801

Title: Progress made and challenges left: perspective from Mississippi.

Journal: Pediatrics 20110801

Title: Response to challenges and lessons learned from Hurricanes Katrina and Rita: a national perspective.

Journal: Pediatrics 20110801

Title: The art of the possible: looking back and ahead 5 years after landfall.

Journal: Pediatrics 20110801

Title: Long buccal nerve block injection pain in patients with irreversible pulpitis.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110701

Title: Atypical presentations of methemoglobinemia from benzocaine spray.

Journal: Hawaii medical journal 20110601

Title: Development, characterization, and in vitro and in vivo evaluation of benzocaine- and lidocaine-loaded nanostructrured lipid carriers.

Journal: Journal of pharmaceutical sciences 20110501

Title: Exploring the effect of supramolecular structures of micelles and cyclodextrins on fluorescence emission of local anesthetics.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20110401

Title: Screening of formulation variables for the preparation of poly(epsilon-caprolactone) nanocapsules containing the local anesthetic benzocaine.

Journal: Journal of nanoscience and nanotechnology 20110301

Title: Methemoglobinemia secondary to over-the-counter Anbesol.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110201

Title: Benzocaine-induced methaemoglobinaemia: a case study.

Journal: British journal of nursing (Mark Allen Publishing) 20110201

Title: Cerumen removal: comparison of cerumenolytic agents and effect on cognition among the elderly.

Journal: Archives of gerontology and geriatrics 20110101

Title: Contact sensitization to the allergens of European baseline series in patients with chronic leg ulcers.

Journal: Medicina (Kaunas, Lithuania) 20110101

Title: Liposome-encapsulated ropivacaine for intraoral topical anesthesia.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20101201

Title: The use of local anesthetic agents in medicine.

Journal: Dental clinics of North America 20101001

Title: Acquired methemoglobinemia revisited.

Journal: Dental clinics of North America 20101001

Title: Anesthesia induces stress in Atlantic salmon (Salmo salar), Atlantic cod (Gadus morhua) and Atlantic halibut (Hippoglossus hippoglossus).

Journal: Fish physiology and biochemistry 20100901

Title: Memories of Katrina continue to hinder mental health recovery in New Orleans.

Journal: JAMA 20100825

Title: New 'drug-in cyclodextrin-in deformable liposomes' formulations to improve the therapeutic efficacy of local anaesthetics.

Journal: International journal of pharmaceutics 20100816

Title: Cetacaine-induced complication during transesophageal echocardiography placement.

Journal: Journal of cardiothoracic and vascular anesthesia 20100801

Title: Bioadhesive films containing benzocaine: correlation between in vitro permeation and in vivo local anesthetic effect.

Journal: Pharmaceutical research 20100801

Title: Liposomal encapsulation improves the duration of soft tissue anesthesia but does not induce pulpal anesthesia.

Journal: Journal of clinical anesthesia 20100801

Title: Is threshold for treatment of methemoglobinemia the same for all? A case report and literature review.

Journal: The American journal of emergency medicine 20100701

Title: Severe methemoglobinemia linked to gel-type topical benzocaine use: a case report.

Journal: The Journal of emergency medicine 20100601

Title: Humane killing of fishes for scientific research: a comparison of two methods.

Journal: Journal of fish biology 20100601

Title: Cocaine can turn you blue as well!

Journal: Anaesthesia 20100601

Title: Angioedema-like allergic contact dermatitis to castor oil.

Journal: Contact dermatitis 20100501

Title: Infection and the risk of topical anesthetic induced clinically significant methemoglobinemia after transesophageal echocardiography.

Journal: Echocardiography (Mount Kisco, N.Y.) 20100301

Title: Efficacy of benzocaine as an anaesthetic for Crucian carp (Carassius carassius).

Journal: Veterinary anaesthesia and analgesia 20100301

Title: 77-year-old woman with back pain and shortness of breath.

Journal: Mayo Clinic proceedings 20100201

Title: White powder, blue patient: methaemoglobinaemia associated with benzocaine-adulterated cocaine.

Journal: Resuscitation 20100101

Title: Banana blues.

Journal: Anesthesia and analgesia 20100101

Title: Do decapod crustaceans have nociceptors for extreme pH?

Journal: PloS one 20100101

Title: Double-blind comparison of two types of benzocaine lozenges for the treatment of acute pharyngitis.

Journal: Arzneimittel-Forschung 20100101

Title: Methemoglobinemia and local anesthesia: what every dentist should know.

Journal: Journal of the Massachusetts Dental Society 20100101

Title: Molecular recognition in the gas phase: benzocaine-phenol as a model of anaesthetic-receptor interaction.

Journal: Physical chemistry chemical physics : PCCP 20091228

Title: A 3-year-old boy with fever and oral lesions. Diagnosis: methemoglobinemia.

Journal: Pediatric annals 20091101

Title: Evaluation and refinement of euthanasia methods for Xenopus laevis.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20090901

Title: Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.

Journal: Circulation research 20090828

Title: On the polymorphism of benzocaine; a low-temperature structural phase transition for form (II).

Journal: Acta crystallographica. Section B, Structural science 20090801

Title: I've heard of a lot of home remedies for soothing a bee sting. What works best?

Journal: Mayo Clinic health letter (English ed.) 20090801

Title: Study of the benzocaine transfer from aqueous solution to the interior of a biological membrane.

Journal: The journal of physical chemistry. B 20090723

Title: Rapid classification of simulated street drug mixtures using Raman spectroscopy and principal component analysis.

Journal: Applied spectroscopy 20090701

Title: Single-crystal diffuse scattering studies on polymorphs of molecular crystals. I. The room-temperature polymorphs of the drug benzocaine.

Journal: Acta crystallographica. Section B, Structural science 20090601

Title: The numerical and functional responses of a granivorous rodent and the fate of Neotropical tree seeds.

Journal: Ecology 20090601

Title: Presumptive benzocaine-induced methemoglobinemia in a slender-tailed meerkat (Suricata suricatta).

Journal: Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20090601

Title: Severe methemoglobinemia from topical benzocaine 7.5% (baby orajel) use for teething pain in a toddler.

Journal: Clinical pediatrics 20090301

Title: Banning benzocaine: of bananas, bureaucrats, and blue men.

Journal: Anesthesia and analgesia 20090301

Title: Methemoglobinemia related to local anesthetics: a summary of 242 episodes.

Journal: Anesthesia and analgesia 20090301

Title: Severe methemoglobinemia detected by pulse oximetry.

Journal: Anesthesia and analgesia 20090301

Title: Effects of intraluminal local anesthetic on upper gastrointestinal motor, sensory, and peptide hormone responses to intraduodenal glucose.

Journal: European journal of gastroenterology & hepatology 20090301

Title: Combined experimental and theoretical study of the benzocaine/Ar van der Waals system in supersonic expansions.

Journal: The journal of physical chemistry. A 20090212

Title: Timely drug delivery from controlled-release devices: dynamic analysis and novel design concepts.

Journal: Mathematical biosciences 20090201

Title: Fish skin as a model membrane: structure and characteristics.

Journal: The Journal of pharmacy and pharmacology 20090101

Title: Acute ischemic cardiomyopathy after extreme emotional stress in a child.

Journal: Congenital heart disease 20090101

Title: Comparative efficacy of 2 topical anesthetics for the placement of orthodontic temporary anchorage devices.

Journal: Anesthesia progress 20090101

Title: ISMP medication safety alert! Benzocaine spray and methemoglobinemia.

Journal: Alberta RN 20090101

Title: Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes.

Journal: Journal of liposome research 20090101

Title: Topical anesthesia for rubber dam clamp placement in sealant placement: comparison of lidocaine/prilocaine gel and benzocaine.

Journal: Pediatric dentistry 20090101

Title: Allergic contact dermatitis from ethyl chloride and benzocaine.

Journal: Dermatitis : contact, atopic, occupational, drug 20090101

Title: [Pepsin-R clinical efficacy in patients with adverse endoscopic GERD].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

Title: Liquor made quicker: alcohol as a synthetic reagent for molecules in anesthesia.

Journal: Journal of clinical anesthesia 20081101

Title: Contact allergy to benzocaine in a condom.

Journal: Contact dermatitis 20080901

Title: More on benzocaine-induced methemoglobinemia.

Journal: The Journal of the American Osteopathic Association 20080801

Title: The local anesthetic butamben inhibits total and L-type barium currents in PC12 cells.

Journal: Anesthesia and analgesia 20080601

Title: Immobilization of paracetamol and benzocaine pro-drug derivatives as long-range self-organized monolayers on graphite.

Journal: Colloids and surfaces. B, Biointerfaces 20080501

Title: T-CAM, a fastatin-FIII 9-10 fusion protein, potently enhances anti-angiogenic and anti-tumor activity via alphavbeta3 and alpha5beta1 integrins.

Journal: Experimental & molecular medicine 20080430

Title: Intraoperative detection of methemoglobinemia in a patient given benzocaine spray to relieve discomfort from a nasogastric tube: a case report.

Journal: AANA journal 20080401

Title: A rare side effect of transesophageal echocardiography: methemoglobinemia from topical benzocaine anesthesia.

Journal: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20080301

Title: A program of anticipatory guidance for the prevention of emergency department visits for ear pain.

Journal: Archives of pediatrics & adolescent medicine 20080201

Title: Otitis media, shared decision making, and enhancing value in pediatric practice.

Journal: Archives of pediatrics & adolescent medicine 20080201

Title: Methemoglobinemia: hypotension and oxygen desaturation after transesophageal echocardiography.

Journal: The Journal of the Arkansas Medical Society 20080201

Title: Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels.

Journal: Circulation research 20080104

Title: Coupling desorption electrospray ionisation and neutral desorption/extractive electrospray ionisation with a travelling-wave based ion mobility mass spectrometer for the analysis of drugs.

Journal: Rapid communications in mass spectrometry : RCM 20080101

Title: Patch-test reactions to topical anesthetics: retrospective analysis of cross-sectional data, 2001 to 2004.

Journal: Dermatitis : contact, atopic, occupational, drug 20080101

Title: Cyanosis following transesophageal echocardiogram.

Journal: The West Virginia medical journal 20080101

Title: Optimization of formulation variables of benzocaine liposomes using experimental design.

Journal: Journal of liposome research 20080101

Title: Topical benzocaine-induced methemoglobinemia in the pediatric population.

Journal: Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 20080101

Title: The dental management of five paediatric patients with a history of acute intermittent porphyria.

Journal: European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry 20071201

Title: Using the rapid response system to provide better oversight of patient care processes.

Journal: Joint Commission journal on quality and patient safety 20071101

Title: Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors.

Journal: Archives of internal medicine 20071008

Title: Comparative spectral analysis of veterinary powder product by continuous wavelet and derivative transforms.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071001

Title: Diplopia after topical pharyngeal anesthesia for transesophageal echocardiography.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20071001

Title: A preliminary study of intra-pocket topical versus injected anaesthetic for scaling and root planing.

Journal: Journal of clinical periodontology 20071001

Title: Development, characterization and in vivo evaluation of benzocaine-loaded liposomes.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070801

Title: Benzocaine-induced methemoglobinemia in two patients: interdisciplinary collaboration, management, and near misses.

Journal: Pharmacotherapy 20070801

Title: Analysis of substances to be used as internal standards in MEKC.

Journal: Electrophoresis 20070601

Title: Methemoglobinemia induced by exposure to topical benzocaine for an awake nasal intubation--a case report.

Journal: Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20070601

Title: Comparison of topical anesthetics (EMLA/Oraqix vs. benzocaine) on pain experienced during palatal needle injection.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20070501

Title: A cyanotic toddler.

Journal: Pediatric emergency care 20070301

Title: Lidocaine alters the input resistance and evokes neural activity in crayfish sensory neurons.

Journal: General physiology and biophysics 20070301

Title: Effect of surfactant on dissolution of spherical particles in micellar systems.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070201

Title: Evaluation of supercritical fluid technology as preparative technique of benzocaine-cyclodextrin complexes--comparison with conventional methods.

Journal: Journal of pharmaceutical and biomedical analysis 20070117

Title: Changes in plasma catecholamine concentration during salinity manipulation and anaesthesia in the hagfish Eptatretus cirrhatus.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20070101

Title: KNO3/benzocaine/tetracaine gel use for maintenance visit pain control.

Journal: General dentistry 20070101

Title: Efficacy of 1% ropivacaine gel for topical anesthesia of human oral mucosa.

Journal: Quintessence international (Berlin, Germany : 1985) 20070101

Title: [Comparison of two forms of nasal and pharyngeal topical anestesia for performing esophageal manometry].

Journal: Revista de gastroenterologia de Mexico 20070101

Title: Methemoglobinemia and benzocaine.

Journal: Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20070101

Title: Methemoglobinemia and transesophageal echo.

Journal: Proceedings of the Western Pharmacology Society 20070101

Title: Methemoglobinemia revisited: an important complication after transesophageal echocardiography.

Journal: European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20061201

Title: Cross-reactions among parabens, para-phenylenediamine, and benzocaine: a retrospective analysis of patch testing.

Journal: Dermatitis : contact, atopic, occupational, drug 20061201

Title: Estrogenic activity of UV filter mixtures.

Journal: Toxicology and applied pharmacology 20061115

Title: Atomic determinants of state-dependent block of sodium channels by charged local anesthetics and benzocaine.

Journal: FEBS letters 20061113

Title: The effect of clove and benzocaine versus placebo as topical anesthetics.

Journal: Journal of dentistry 20061101

Title: Erosive papulonodular dermatosis associated with topical benzocaine: a report of two cases and evidence that granuloma gluteale, pseudoverrucous papules, and Jacquet's erosive dermatitis are a disease spectrum.

Journal: Journal of the American Academy of Dermatology 20061101

Title: Multiple hormonal activities of UV filters and comparison of in vivo and in vitro estrogenic activity of ethyl-4-aminobenzoate in fish.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20061012

Title: Differential effects of anesthetics on electrical properties of the rainbow trout (Oncorhynchus mykiss) heart.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20061001

Title: Solubility parameter of drugs for predicting the solubility profile type within a wide polarity range in solvent mixtures.

Journal: International journal of pharmaceutics 20060914

Title: Interaction of local anesthetics with a peptide encompassing the IV/S4-S5 linker of the Na+ channel.

Journal: Biophysical chemistry 20060820

Title: Evaluation of topical pharyngeal anaesthesia by benzocaine lozenge for upper endoscopy.

Journal: Alimentary pharmacology & therapeutics 20060815

Title: Benzocaine anaphylaxis.

Journal: The Journal of allergy and clinical immunology 20060801

Title: Efficacy of intraoral topical anesthetics in children.

Journal: Journal of dentistry 20060701

Title: Double-blind study on the effects of topical anesthesia on laryngeal secretions.

Journal: Journal of voice : official journal of the Voice Foundation 20060601

Title: Oscar Costa-Mandry and posthurricane bacillary dysentery.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060601

Title: Methemoglobinemia after fiberoptic intubation in a patient with an unstable cervical fracture: a case report.

Journal: Journal of spinal disorders & techniques 20060601

Title: Allergic contact stomatitis.

Journal: Dermatitis : contact, atopic, occupational, drug 20060601

Title: A novel in vitro percutaneous penetration model: evaluation of barrier properties with p-aminobenzoic acid and two of its derivatives.

Journal: Pharmaceutical research 20060501

Title: Transportation of juvenile tambaqui (Colossoma macropomum) in a closed system.

Journal: Brazilian journal of biology = Revista brasleira de biologia 20060501

Title: Silhouette of pain.

Journal: Academic medicine : journal of the Association of American Medical Colleges 20060401

Title: Severe methemoglobinemia complicating topical benzocaine use during endoscopy in a toddler: a case report and review of the literature.

Journal: Pediatrics 20060401

Title: Methemoglobinemia following transesophageal echocardiography: a case report and review.

Journal: Echocardiography (Mount Kisco, N.Y.) 20060401

Title: Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.

Journal: Neuroscience letters 20060313

Title: Salt effects on an ion-molecule reaction--hydroxide-catalyzed hydrolysis of benzocaine.

Journal: Pharmaceutical research 20060301

Title: Hydrogen peroxide burn of the oral mucosa.

Journal: The Annals of pharmacotherapy 20060201

Title: Contact urticaria and allergic contact dermatitis to lidocaine in a patient sensitive to benzocaine and propolis.

Journal: Contact dermatitis 20060201

Title: A nurse sends thanks for advice on treating a 'wild reaction'.

Journal: RN 20060201

Title: Methemoglobinemia after transesophageal echocardiography: a life-threatening complication.

Journal: Journal of clinical anesthesia 20060201

Title: The local anesthetic butamben inhibits and accelerates low-voltage activated T-type currents in small sensory neurons.

Journal: Anesthesia and analgesia 20060101

Title: When brown and blue make red: a case of acquired methemoglobinemia.

Journal: Heart & lung : the journal of critical care 20060101

Title: Methemoglobinemia-induced cardio-respiratory failure secondary to topical anesthesia.

Journal: American journal of therapeutics 20060101

Title: Evaluation of three topical anaesthetic agents against pain: a clinical study.

Journal: Indian journal of dental research : official publication of Indian Society for Dental Research 20060101

Title: [Comparison of the systems used for providing local anesthesia in dentistry--the Wand (Milestone Scientific) and Injex (Rosch)].

Journal: Przeglad lekarski 20060101

Title: The 'bubble point' for validation of drug release or simulated absorption tests for ointments.

Journal: Die Pharmazie 20051201

Title: [Anogenital dermatoses--allergic and irritative causative factors. Analysis of IVDK data and review of the literature].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20051201

Title: Death of an infant involving benzocaine.

Journal: Journal of forensic sciences 20051101

Title: Decreased efficacy of topical anesthetic creams in presence of benzoyl peroxide.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20051101

Title: A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC.

Journal: Journal of pharmaceutical and biomedical analysis 20051004

Title: Physico-chemical characterization of benzocaine-beta-cyclodextrin inclusion complexes.

Journal: Journal of pharmaceutical and biomedical analysis 20051004

Title: Topical anesthetic sprays directly associated with a serious, sometimes fatal adverse drug reaction: methemoglobinemia.

Journal: Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20051001

Title: A wild reaction to a topical anesthetic.

Journal: RN 20051001

Title: Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben.

Journal: The Journal of pharmacology and experimental therapeutics 20050901

Title: Case study of benzocaine-induced methemoglobinemia.

Journal: Journal - Oklahoma Dental Association 20050901

Title: Avoiding topical anesthesia-induced methemoglobinemia.

Journal: Obesity surgery 20050801

Title: Benzocaine-induced methemoglobinemia during transesophageal echocardiography.

Journal: The Journal of the American Osteopathic Association 20050801

Title: What's your diagnosis? Acute vulvar erythema, edema, and pruritus in a young woman.

Journal: Journal of pediatric and adolescent gynecology 20050801

Title: Structural characteristics and crystal polymorphism of three local anaesthetic bases crystal polymorphism of local anaesthetic drugs: part VII.

Journal: International journal of pharmaceutics 20050714

Title: Physicochemical characterization of polymeric micelles constructed from novel amphiphilic polyphosphazene with poly(N-isopropylacrylamide) and ethyl 4-aminobenzoate as side groups.

Journal: Colloids and surfaces. B, Biointerfaces 20050710

Title: Topical analgesia for endometrial biopsy: a randomized controlled trial.

Journal: Obstetrics and gynecology 20050701

Title: Sequential enzymatic oxidation of aminoarenes to nitroarenes via hydroxylamines.

Journal: Angewandte Chemie (International ed. in English) 20050627

Title: The block of total and N-type calcium conductance in mouse sensory neurons by the local anesthetic n-butyl-p-aminobenzoate.

Journal: Anesthesia and analgesia 20050601

Title: Local anesthetics facilitate ion transport across lipid planar bilayer membranes under an electric field: dependence on type of lipid bilayer.

Journal: Colloids and surfaces. B, Biointerfaces 20050525

Title: Benzocaine: not dangerous enough?

Journal: Pediatrics 20050501

Title: Non-invasive monitoring of muscle blood perfusion by photoplethysmography: evaluation of a new application.

Journal: Acta physiologica Scandinavica 20050401

Title: Topical benzocaine (Hurricaine) induced methemoglobinemia during endoscopic procedures in gastric bypass patients.

Journal: Obesity surgery 20050401

Title: The use of folk remedies among children in an urban black community: remedies for fever, colic, and teething.

Journal: Pediatrics 20050301

Title: Effects of tramadol on nerve action potentials in rat: comparisons with benzocaine and lidocaine.

Journal: The International journal of neuroscience 20050301

Title: Methemoglobinemia secondary to topical benzocaine use in a lung transplant patient.

Journal: The Annals of pharmacotherapy 20050201

Title: Modeling of benzocaine analog interactions with the D4S6 segment of NaV4.1 voltage-gated sodium channels.

Journal: Biophysical chemistry 20050101

Title: Tricaine (MS-222) is a safe anesthetic compound compared to benzocaine and pentobarbital to induce anesthesia in leopard frogs (Rana pipiens).

Journal: Pharmacological reports : PR 20050101

Title: Reduction of pain from needle stick in the oral mucosa by topical anesthetics: a comparative study between lidocaine/prilocaine and benzocaine.

Journal: The Journal of clinical dentistry 20050101

Title: Giving birth: a midwife's faith in birth is reborn.

Journal: Midwifery today with international midwife 20050101

Title: A study of benzocaine gel dosing for toothache.

Journal: The Journal of clinical dentistry 20050101

Title: Benzocaine-induced methemoglobinemia.

Journal: Anesthesia progress 20050101

Title: Solubility and phase separation of benzocaine and salicylic acid in 1,4-dioxane-water mixtures at several temperatures.

Journal: Journal of pharmaceutical and biomedical analysis 20041115

Title: Methemoglobinemia: early intraoperative detection by clinical observation.

Journal: The Laryngoscope 20041101

Title: Benzocaine-induced methemoglobinemia: a condition of which all endoscopists should be aware.

Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20041001

Title: A new look at the hemolytic effect of local anesthetics, considering their real membrane/water partitioning at pH 7.4.

Journal: Biophysical chemistry 20040801

Title: Management of earwax in primary care--postal survey of UK GPs and practice nurses.

Journal: Family practice 20040801

Title: Methemoglobinemia: sudden dyspnea and oxyhemoglobin desaturation after esophagoduodenoscopy.

Journal: Respiratory care 20040801

Title: A PACU crisis: a case study on the development and management of methemoglobinemia.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20040801

Title: Allergic contact dermatitis to condoms: description of a clinical case and analytical review of current literature.

Journal: Immunopharmacology and immunotoxicology 20040801

Title: Prospective randomized study of viscous lidocaine versus benzocaine in a GI cocktail for dyspepsia.

Journal: The Journal of emergency medicine 20040701

Title: Reported adverse event cases of methemoglobinemia associated with benzocaine products.

Journal: Archives of internal medicine 20040614

Title: Iatrogenic methemoglobinemia from benzocaine spray in trauma.

Journal: The American journal of emergency medicine 20040501

Title: Tongue entrapment in an aluminum juice can.

Journal: Pediatric emergency care 20040401

Title: Effects of the local anesthetic benzocaine on the human erythrocyte membrane and molecular models.

Journal: Biophysical chemistry 20040401

Title: Critical rebound methemoglobinemia after methylene blue treatment: case report.

Journal: Pharmacotherapy 20040401

Title: Respiratory failure secondary to methemoglobinemia induced by benzocaine: a case report.

Journal: South Dakota journal of medicine 20040401

Title: The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia.

Journal: Journal of clinical gastroenterology 20040301

Title: Acute methemoglobinemia after endoscopy.

Journal: The Journal of the American Board of Family Practice 20040101

Title: Methemoglobinemia caused by topical teething preparation: a case report.

Journal: TheScientificWorldJournal 20040101

Title: Influence of liposomal local anesthetics on platelet aggregation in vitro.

Journal: Journal of liposome research 20040101

Title: Analgesic synergy between topical morphine and butamben in mice.

Journal: Anesthesia and analgesia 20031001

Title: Colorimetric determination of benzocaine, lignocaine and procaine hydrochlorides in pure form and in pharmaceutical formulations using p-benzoquinone.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20031001

Title: Lipid-protein interactions and effect of local anesthetics in acetylcholine receptor-rich membranes from Torpedo marmorata electric organ.

Journal: Biochemistry 20030805

Title: Angioedema as a complication of upper endoscopy.

Journal: Annals of internal medicine 20030805

Title: Dangerous in small amounts: ten nondrug substances that cause harm.

Journal: Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20030801

Title: Preparation and evaluation of bioadhesive benzocaine gels for enhanced local anesthetic effects.

Journal: International journal of pharmaceutics 20030709

Title: Bye-bye benzocaine?

Journal: Nursing 20030701

Title: Effects of isoeugenol on in vitro neuromuscular blockade of rat phrenic nerve-diaphragm preparations.

Journal: American journal of veterinary research 20030601

Title: Influence of site preparation methods on the pain reported during palatal infiltration using the Wand Local Anesthetic System.

Journal: American journal of dentistry 20030601

Title: Two cases of methemoglobinemia from the use of topical anesthetics.

Journal: Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association 20030401

Title: Spectrophotometric determination of labetalol in pharmaceutical preparations and spiked human urine.

Journal: Farmaco (Societa chimica italiana : 1989) 20030401

Title: Suspected methemoglobinemia following awake intubation: one possible effect of benzocaine topical anesthesia--a case report.

Journal: AANA journal 20030401

Title: Thermodynamics of partitioning of benzocaine in some organic solvent/buffer and liposome systems.

Journal: Chemical & pharmaceutical bulletin 20030301

Title: Benzocaine-induced methemoglobinemia.

Journal: Nursing 20030301

Title: Effect of prolonged exposure to low antigen concentration for sensitization.

Journal: Toxicology 20030214

Title: Kv1.1 channels of dorsal root ganglion neurons are inhibited by n-butyl-p-aminobenzoate, a promising anesthetic for the treatment of chronic pain.

Journal: The Journal of pharmacology and experimental therapeutics 20030201

Title: Benzocaine-induced methemoglobinemia: experience from a high-volume transesophageal echocardiography laboratory.

Journal: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20030201

Title: Black henna tattoo reaction in a person with sulfonamide and benzocaine drug allergies.

Journal: Journal of the American Academy of Dermatology 20030201

Title: Anesthesia of fish with benzocaine does not interfere with comet assay results.

Journal: Mutation research 20030110

Title: Methemoglobinemia and topical pharyngeal anesthesia.

Journal: The New England journal of medicine 20030102

Title: Efficacy and tolerability of an intraoral benzocaine patch in the relief of spontaneous toothache pain.

Journal: The Journal of clinical dentistry 20030101

Title: Severe methemoglobinemia after transesophageal echocardiography.

Journal: American journal of therapeutics 20030101

Title: Children's preference of benzocaine gel versus the lidocaine patch.

Journal: Pediatric dentistry 20030101

Title: Benzocaine-induced methemoglobinemia: a potentially fatal complication of transesophageal echocardiography.

Journal: Texas Heart Institute journal 20030101

Title: Effectiveness of 20% benzocaine as a topical anesthetic for intraoral injections.

Journal: Anesthesia progress 20030101

Title: Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors.

Journal: The Journal of biological chemistry 20021115

Title: Putative binding sites for benzocaine on a human cardiac cloned channel (Kv1.5).

Journal: Cardiovascular research 20021001

Title: Efficacy of a wax containing benzocaine in the relief of oral mucosal pain caused by orthodontic appliances.

Journal: American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 20021001

Title: Effective topical anesthetic agents and techniques.

Journal: Dental clinics of North America 20021001

Title: The use of lubricants to achieve tracheal intubation in neonates and infants.

Journal: Paediatric anaesthesia 20021001

Title: A study of release mechanisms of different ophthalmic drugs from erodible ocular inserts based on poly(ethylene oxide).

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020901

Title: Methemoglobinemia induced by topical benzocaine: a warning for the endoscopist.

Journal: Endoscopy 20020901

Title: Comparison of topical anesthesia of 20% benzocaine and 60% lidocaine gel.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20020801

Title: Local lymph node assay with non-radioisotope alternative endpoints.

Journal: The Journal of toxicological sciences 20020801

Title: The role of fat and cholecystokinin in functional dyspepsia.

Journal: Gut 20020701

Title: Methemoglobinemia as a cause of respiratory failure.

Journal: The Journal of trauma 20020401

Title: Effects of anaesthesia on blood gases, acid-base status and ions in the toad Bufo marinus.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020301

Title: The antinociceptive and histologic effect of sciatic nerve blocks with 5% butamben suspension in rats.

Journal: Anesthesia and analgesia 20020301

Title: Perioperatively acquired methaemoglobinaemia in a preterm infant.

Journal: Paediatric anaesthesia 20020301

Title: General solution for diffusion-controlled dissolution of spherical particles. 2. Evaluation of experimental data.

Journal: Journal of pharmaceutical sciences 20020201

Title: Effects of four anaesthetics on the innate immune response of gilthead seabream (Sparus aurata L.).

Journal: Fish & shellfish immunology 20020101

Title: Granuloma gluteale adultorum associated with use of topical benzocaine preparations: case report and literature review.

Journal: Journal of cutaneous medicine and surgery 20020101

Title: Should a mucoadhesive patch (DentiPatch) be used for gingival anesthesia in children?

Journal: Anesthesia progress 20020101

Title: The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20011101

Title: [The killing of aquarium fish by owners: a commentary].

Journal: Tijdschrift voor diergeneeskunde 20010901

Title: Evaluation of an acetic acid ester of monoglyceride as a suppository base with unique properties.

Journal: AAPS PharmSciTech 20010901

Title: [The killing of aquarium fish by their owners].

Journal: Tijdschrift voor diergeneeskunde 20010701

Title: A potentially fatal effect of topical anesthesia.

Journal: Hospital practice (1995) 20010615

Title: Benzocaine-induced methemoglobinemia accompanying adult respiratory distress syndrome and sepsis syndrome: case report.

Journal: The Journal of trauma 20010601

Title: Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics.

Journal: British journal of pharmacology 20010501

Title: Clinical evaluation and comparison of 2 topical anesthetics for pain caused by needle sticks and scaling and root planing.

Journal: Journal of periodontology 20010401

Title: Severe methemoglobinemia on reexposure to benzocaine.

Journal: Journal of clinical anesthesia 20010301

Title: Canister tip orientation and residual volume have significant impact on the dose of benzocaine delivered by Hurricaine spray.

Journal: Anesthesia and analgesia 20010201

Title: Allergic contact dermatitis from benzocaine ointment during treatment of herpes zoster.

Journal: Contact dermatitis 20010201

Title: Drug-induced methemoglobinemia during thoracoscopic lung biopsy.

Journal: The Annals of thoracic surgery 20010201

Title: Modulation of gastric distension-induced sensations by small intestinal receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010101

Title: Analgesia for colposcopy: double-masked, randomized comparison of ibuprofen and benzocaine gel.

Journal: Obstetrics and gynecology 20010101

Title: Placement of the esophageal Doppler ultrasound monitor probe in awake patients.

Journal: Chest 20010101

Title: Comparison of topical EMLA 5% oral adhesive to benzocaine 20% on the pain experienced during palatal anesthetic infiltration in children.

Journal: Pediatric dentistry 20010101

Title: Reducing children's injection pain: lidocaine patches versus topical benzocaine gel.

Journal: Pediatric dentistry 20010101

Title: A survey of local and topical anesthesia use by pediatric dentists in the United States.

Journal: Pediatric dentistry 20010101

Title: Redox properties of local anesthetics: A structural determinant of closed channel blockers in BTX-modified Na+ channels.

Journal: Membrane & cell biology 20010101

Title: Controlled release from an electrorheological fluid dosage form: experimental results for a prototype system.

Journal: PDA journal of pharmaceutical science and technology 20010101

Title: Fluorescent labeling of drugs and simple organic compounds containing amine functional groups, utilizing dansyl chloride in Na(2)CO(3) buffer.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Expression of T-cell cytokines in challenged skin of murine allergic contact photosensitivity: low responsiveness is associated with induction of Th2 cytokines.

Journal: Journal of dermatological science 20000601

Title: Toxic methemoglobinemia: a rare but serious complication of transesophageal echocardiography.

Journal: The Canadian journal of cardiology 19980901

Title: Structure of an allergenic pentasaccharitol, Gp-1 beta-b6, isolated from a sea squirt antigen, Gi-rep, as a minimum structural unit responsible for its allergenicity.

Journal: Journal of biochemistry 19900701

Title: Effect of epidural and subarachnoid injections of a 10% butamben suspension.

Journal: Regional anesthesia 19900101

Title: Use of verbal descriptors, thermal scores and electrical pulp testing as predictors of tooth pain before and after application of benzocaine gels into cavities of teeth with pulpitis.

Journal: Anesthesia progress 19890101

Title: [Methemoglobinemia and acute toxic hemolytic anemia caused by gingival lotion with a benzocaine and resorcinol base].

Journal: Presse medicale (Paris, France : 1983) 19851005

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SDS
Tags:23239-88-5 Molecular Formula|23239-88-5 MDL|23239-88-5 SMILES|23239-88-5 Benzoic acid, 4-amino-, ethyl ester, hydrochloride (1:1)