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23266-24-2,MFCD20134020
Catalog No.:AA01C5N6

23266-24-2 | 1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01C5N6
Chemical Name:
1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS Number:
23266-24-2
Molecular Formula:
C11H15N
Molecular Weight:
161.2435
MDL Number:
MFCD20134020
SMILES:
CC1CNCCc2c1cccc2
Properties
Computed Properties
 
Complexity:
144  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.1  

Downstream Synthesis Route

[1]Smith,BrianM.;Smith,JeffreyM.;Tsai,JamesH.;Schultz,JeffreyA.;Gilson,CharlesA.;Estrada,ScottA.;Chen,RitaR.;Park,DouglasM.;Prieto,EmilyB.;Gallardo,CharlemagneS.;Sengupta,Dipanjan;Thomsen,WilliamJ.;Saldana,HazelR.;Whelan,KevinT.;Menzaghi,Frederique;Webb,RobertR.;Beeley,NigelR.A.[BioorganicandMedicinalChemistryLetters,2005,vol.15,#5,p.1467-1470]

[2]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-WO2008/80891,2008,A2Locationinpatent:Page/Pagecolumn121

[3]CurrentPatentAssignee:SYGNATUREDISCOVERYLTD;OTSUKAHOLDINGSCOLTD-WO2017/68412,2017,A1Locationinpatent:Page/Pagecolumn240

[1]Smith,BrianM.;Smith,JeffreyM.;Tsai,JamesH.;Schultz,JeffreyA.;Gilson,CharlesA.;Estrada,ScottA.;Chen,RitaR.;Park,DouglasM.;Prieto,EmilyB.;Gallardo,CharlemagneS.;Sengupta,Dipanjan;Thomsen,WilliamJ.;Saldana,HazelR.;Whelan,KevinT.;Menzaghi,Frederique;Webb,RobertR.;Beeley,NigelR.A.[BioorganicandMedicinalChemistryLetters,2005,vol.15,#5,p.1467-1470]

[2]CurrentPatentAssignee:SYGNATUREDISCOVERYLTD;OTSUKAHOLDINGSCOLTD-WO2017/68412,2017,A1

[1]Smith,BrianM.;Smith,JeffreyM.;Tsai,JamesH.;Schultz,JeffreyA.;Gilson,CharlesA.;Estrada,ScottA.;Chen,RitaR.;Park,DouglasM.;Prieto,EmilyB.;Gallardo,CharlemagneS.;Sengupta,Dipanjan;Thomsen,WilliamJ.;Saldana,HazelR.;Whelan,KevinT.;Menzaghi,Frederique;Webb,RobertR.;Beeley,NigelR.A.[BioorganicandMedicinalChemistryLetters,2005,vol.15,#5,p.1467-1470]

64-18-6    23266-24-2   
1-methyl-2,3,4,5-tetrahydro-1H-benzodazepineformicacidsalt 

[1]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-WO2008/80891,2008,A2Locationinpatent:Page/Pagecolumn121

Literature

Title: Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.

Journal: Journal of medicinal chemistry 20080124

Title: Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.

Journal: Bioorganic & medicinal chemistry letters 20050301

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Tags:23266-24-2 Molecular Formula|23266-24-2 MDL|23266-24-2 SMILES|23266-24-2 1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine