Home Fluorides 23674-86-4
23674-86-4,MFCD00214273
Catalog No.:AA0039JI

23674-86-4 | (6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion

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5mg
95%
in stock  
$47.00   $33.00
- +
10mg
≥98%
in stock  
$49.00   $34.00
- +
25mg
≥98%
in stock  
$102.00   $71.00
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50mg
>98.0%(HPLC)
in stock  
$130.00   $91.00
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100mg
95%
in stock  
$229.00   $160.00
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500mg
95%
in stock  
$686.00   $480.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039JI
Chemical Name:
(6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion
CAS Number:
23674-86-4
Molecular Formula:
C27H34F2O7
Molecular Weight:
508.5515
MDL Number:
MFCD00214273
SMILES:
CCCC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2C[C@@H](C2=CC(=O)C=C[C@]12C)F)F)C(=O)COC(=O)C
Properties
Computed Properties
 
Complexity:
1050  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
3.4  

Literature

Title: Treatment of diffuse diabetic macular oedema using steroid eye drops.

Journal: Acta ophthalmologica 20121101

Title: Hypopyon uveitis following LASIK in a patient with ulcerative colitis.

Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) 20120801

Title: Efficacy and potential complications of difluprednate use for pediatric uveitis.

Journal: American journal of ophthalmology 20120501

Title: Vogt-Koyanagi-Harada syndrome in a 6-year-old Hispanic boy.

Journal: Pediatric dermatology 20120101

Title: Graft rejection after Descemet's stripping automated endothelial keratoplasty: graft survival and endothelial cell loss.

Journal: Ophthalmology 20120101

Title: Chronic anterior uveitis in common variable immunodeficiency.

Journal: Ocular immunology and inflammation 20111201

Title: A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery.

Journal: American journal of ophthalmology 20111001

Title: Elevation of intraocular pressure in patients with uveitis treated with topical difluprednate.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20110501

Title: Difluprednate for inflammatory eye disorders.

Journal: Drugs of today (Barcelona, Spain : 1998) 20110501

Title: Effects of twice-daily topical difluprednate 0.05% emulsion in a child with pars planitis.

Journal: Ocular immunology and inflammation 20110201

Title: Ocular distribution of difluprednate ophthalmic emulsion 0.05% in rabbits.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110201

Title: Pharmacokinetic features of difluprednate ophthalmic emulsion in rabbits as determined by glucocorticoid receptor-binding bioassay.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110201

Title: Intraocular pressure elevation from topical difluprednate use.

Journal: Optometry (St. Louis, Mo.) 20101201

Title: Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101001

Title: Metabolic profiles of difluprednate in rabbit ocular tissues after instillation of difluprednate ophthalmic emulsion.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100801

Title: Steroid eye drop treatment (difluprednate ophthalmic emulsion) is effective in reducing refractory diabetic macular edema.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20100601

Title: New drugs 09, part 2.

Journal: Nursing 20090601

Title: Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain.

Journal: Journal of cataract and refractive surgery 20090101

Title: The role of difluprednate ophthalmic emulsion in clinical practice.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20090101

Title: New drugs: Clevidipine butyrate, difluprednate, and tetrabenazine.

Journal: Journal of the American Pharmacists Association : JAPhA 20080101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Injection site with generalized rash caused by pegylated interferon alpha 2a injection.

Journal: Dermatology (Basel, Switzerland) 20060101

Title: Formulation of an ophthalmic lipid emulsion containing an anti-inflammatory steroidal drug, difluprednate.

Journal: International journal of pharmaceutics 20050914

Title: Cutaneous reactions to imatinib mesylate treated by topical steroid.

Journal: American journal of hematology 20050301

Title: Analysis of an anti-inflammatory steroidal drug, difluprednate, in aqueous humor by combination of semi-micro HPLC and column switching method.

Journal: Journal of pharmaceutical and biomedical analysis 20030115

Title: Neuronal cell bodies in the hypothalamic paraventricular nucleus mediate stress-induced renin and corticosterone secretion.

Journal: Neuroendocrinology 19890701

Title: Difluprednate, From Wikipedia

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SDS
Tags:23674-86-4 Molecular Formula|23674-86-4 MDL|23674-86-4 SMILES|23674-86-4 (6α,11β)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-17-(1-oxobutoxy)pregna-1,4-diene-3,20-dion