Title: Design, synthesis and in vitro evaluation of pyridinium ion based cyclase inhibitors and antifungal agents.
Journal: Bioorganic & medicinal chemistry 19960101
Pyridinium p-toluenesulfonate serves as a versatile co-catalyst in various organic transformations, enhancing both the yield and enantioselectivity of asymmetric aldol condensation reactions between dioxanones and aldehydes. Its presence alongside L-proline optimizes the reaction conditions, leading to improved outcomes in terms of both product quantity and chiral purity. Moreover, Pyridinium p-toluenesulfonate exhibits high efficiency as a catalyst in the synthesis of tetrahydropyranyl ethers, particularly in the context of hydroxyl group protection reactions using 1,4-dihydropyridine (DHP). This compound, also known as Pyridinium p-toluenesulfonate, plays a crucial role in facilitating the formation of tetrahydropyranyl ethers, which are widely utilized as protective groups for hydroxyl functionalities in organic synthesis.
