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241800-97-5,MFCD09971126
Catalog No.:AA007O1C

241800-97-5 | Zoniporide dihydrochloride

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1mg
≥98%
in stock  
$53.00   $37.00
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5mg
≥98%
in stock  
$129.00   $90.00
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10mg
≥98%
in stock  
$230.00   $161.00
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50mg
≥98%
in stock  
$983.00   $688.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007O1C
Chemical Name:
Zoniporide dihydrochloride
CAS Number:
241800-97-5
Molecular Formula:
C17H18Cl2N6O
Molecular Weight:
393.2704
MDL Number:
MFCD09971126
SMILES:
NC(=NC(=O)c1cnn(c1C1CC1)c1cccc2c1cccn2)N.Cl.Cl
Properties
Computed Properties
 
Complexity:
515  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Chemical stability of amorphous materials: specific and general media effects in the role of water in the degradation of freeze-dried zoniporide.

Journal: Journal of pharmaceutical sciences 20120901

Title: Effect of structural variation on aldehyde oxidase-catalyzed oxidation of zoniporide.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801

Title: Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120301

Title: Cross-reactivity of acid-sensing ion channel and Na⁺-H⁺ exchanger antagonists with nicotinic acetylcholine receptors.

Journal: The Journal of physiology 20111101

Title: Role of the spinal Na+/H+ exchanger in formalin-induced nociception.

Journal: Neuroscience letters 20110821

Title: Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation - the rat isolated working heart.

Journal: British journal of pharmacology 20110201

Title: Cross-species comparison of the metabolism and excretion of zoniporide: contribution of aldehyde oxidase to interspecies differences.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100401

Title: Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress?

Journal: Journal of molecular and cellular cardiology 20090201

Title: Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct.

Journal: Brain research 20090112

Title: Na+/H+ exchanger-1 inhibitors reduce neuronal excitability and alter na+ channel inactivation properties in rat primary sensory neurons.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080601

Title: Neurotoxic effects of zoniporide: a selective inhibitor of the NA+/H+ exchanger isoform 1.

Journal: Toxicologic pathology 20080601

Title: Does the use of a volatile anesthetic regimen attenuate the incidence of cardiac events after vascular surgery?

Journal: Acta anaesthesiologica Belgica 20080101

Title: Solute diffusion through stripped mouse duodenum.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071201

Title: Zoniporide preserves left ventricular compliance during ventricular fibrillation and minimizes postresuscitation myocardial dysfunction through benefits on energy metabolism.

Journal: Critical care medicine 20071001

Title: The rise of [Na(+)] (i) during ischemia and reperfusion in the rat heart-underlying mechanisms.

Journal: Pflugers Archiv : European journal of physiology 20070901

Title: Initial rate analysis of zoniporide hydrolysis degradants using high-performance liquid chromatography coupled with mass spectrometric detection.

Journal: Pharmaceutical development and technology 20070101

Title: Efficacy of zoniporide, an Na/H exchange ion inhibitor, for reducing perioperative cardiovascular events in vascular surgery patients.

Journal: Journal of cardiothoracic and vascular anesthesia 20051001

Title: Cardioprotective efficacy of zoniporide, a potent and selective inhibitor of Na+/H+ exchanger isoform 1, in an experimental model of cardiopulmonary bypass.

Journal: British journal of pharmacology 20040501

Title: Basolateral Na+-H+ exchanger-1 in rat taste receptor cells is involved in neural adaptation to acidic stimuli.

Journal: The Journal of physiology 20040401

Title: Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1).

Journal: Cardiovascular drug reviews 20030101

Title: Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

Journal: European journal of pharmacology 20020906

Title: A novel sodium-hydrogen exchanger isoform-1 inhibitor, zoniporide, reduces ischemic myocardial injury in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.

Journal: Bioorganic & medicinal chemistry letters 20010326

Title: Tracey WR, et al. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovasc Drug Rev. 2003 Spring;21(1):17-32.

Title: Guzman-Perez A, et al. Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility. Bioorg Med Chem Lett. 2001 Mar 26;11(6):803-7.

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