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2430-27-5,MFCD00051534
Catalog No.:AA003F99

2430-27-5 | 2,2-DI-N-PROPYLACETAMIDE

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10mg
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50mg
97%
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1g
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$95.00   $67.00
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5g
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25g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003F99
Chemical Name:
2,2-DI-N-PROPYLACETAMIDE
CAS Number:
2430-27-5
Molecular Formula:
C8H17NO
Molecular Weight:
143.2267
MDL Number:
MFCD00051534
SMILES:
CCCC(C(=O)N)CCC
Properties
Properties
 
BP:
274.6°C at 760 mmHg  
Form:
Solid  
MP:
123-125°C  
Refractive Index:
1.4614 (estimate)  
Solubility:
DMSO: >10mg/mL  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
95.4  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.1  

Literature

Title: Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130101

Title: Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

Journal: Disease models & mechanisms 20120301

Title: A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.

Journal: Epilepsia 20120101

Title: Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.

Journal: PloS one 20120101

Title: Histone deacetylases are required for amphibian tail and limb regeneration but not development.

Journal: Mechanisms of development 20120101

Title: Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes.

Journal: Neuroscience letters 20110622

Title: [Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20110601

Title: Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.

Journal: Seminars in cell & developmental biology 20110201

Title: Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.

Journal: PloS one 20110101

Title: Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.

Journal: PLoS currents 20101028

Title: Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20100801

Title: Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.

Journal: The Journal of biological chemistry 20100402

Title: [Pharmacokinetics of biological tags in a case of acute valpromide self poisoning].

Journal: Annales de biologie clinique 20100101

Title: [Therapeutic drug monitoring of valproate].

Journal: Therapie 20100101

Title: Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia.

Journal: Molecular pain 20100101

Title: Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.

Journal: Journal of medicinal chemistry 20091126

Title: Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation.

Journal: Journal of neurochemistry 20091101

Title: [Neonatal Volkmann's syndrome].

Journal: Annales de dermatologie et de venereologie 20091101

Title: Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage.

Journal: Journal of the American Chemical Society 20090603

Title: Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.

Journal: Journal of medicinal chemistry 20090423

Title: Agomelatine: The evidence for its place in the treatment of depression.

Journal: Core evidence 20090101

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Application of a metabolizing system as an adjunct to the rat whole embryo culture.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080801

Title: [Effects of acupuncture under guidance of qi street theory on endocrine function in the patient of epilepsy].

Journal: Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20080701

Title: Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.

Journal: Neurochemical research 20080601

Title: Valproic acid extends Caenorhabditis elegans lifespan.

Journal: Aging cell 20080601

Title: Acute and long-term treatment of mania.

Journal: Dialogues in clinical neuroscience 20080601

Title: Evaluation of the enantioselective antiallodynic and pharmacokinetic profile of propylisopropylacetamide, a chiral isomer of valproic acid amide.

Journal: Neuropharmacology 20080301

Title: The effectiveness of anticonvulsants in psychiatric disorders.

Journal: Dialogues in clinical neuroscience 20080301

Title: Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments.

Journal: Cell cycle (Georgetown, Tex.) 20080215

Title: Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells.

Journal: British journal of pharmacology 20080201

Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.

Journal: Perspectives in medicinal chemistry 20080101

Title: Lipid peroxidation in women with epilepsy.

Journal: Annals of Indian Academy of Neurology 20080101

Title: Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid.

Journal: Journal of medicinal chemistry 20071213

Title: Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data.

Journal: Bipolar disorders 20070901

Title: The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior.

Journal: Molecular pharmacology 20070301

Title: The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver.

Journal: British journal of pharmacology 20061001

Title: S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060401

Title: Management of epilepsy in adults. Diagnosis guidelines.

Journal: Postgraduate medicine 20051201

Title: Catalytic mechanism of limonene epoxide hydrolase, a theoretical study.

Journal: Journal of the American Chemical Society 20051019

Title: Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors.

Journal: Journal of cellular biochemistry 20051015

Title: Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain.

Journal: British journal of pharmacology 20050901

Title: Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.

Journal: Biochemical pharmacology 20050515

Title: The role of histone acetylation in SMN gene expression.

Journal: Human molecular genetics 20050501

Title: Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20050401

Title: [Management of bipolar disorders].

Journal: La Revue du praticien 20050315

Title: Mood stabilizer augmentation in apparently 'unipolar' MDD: predictors of response in the naturalistic French national EPIDEP study.

Journal: Journal of affective disorders 20050201

Title: [Valpromide poisoning associated with circulatory collapse].

Journal: Therapie 20050101

Title: Valproate decreases inositol biosynthesis.

Journal: Biological psychiatry 20041201

Title: Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.

Journal: Bioorganic & medicinal chemistry letters 20041115

Title: Polycomb homologs are involved in teratogenicity of valproic acid in mice.

Journal: Birth defects research. Part A, Clinical and molecular teratology 20041101

Title: [Deep lactic acidosis after valproate self-poisoning].

Journal: Annales francaises d'anesthesie et de reanimation 20041001

Title: Characterization of the anticonvulsant profile of valpromide derivatives.

Journal: Bioorganic & medicinal chemistry 20040715

Title: Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis.

Journal: The Journal of biological chemistry 20040430

Title: Delayed toxicity following acute ingestion of valpromide.

Journal: Human & experimental toxicology 20040301

Title: Valproate potentiates androgen biosynthesis in human ovarian theca cells.

Journal: Endocrinology 20040201

Title: Amidic modification of valproic acid reduces skeletal teratogenicity in mice.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20040201

Title: [Valpromide, Valproic acid and removal of small intestine in the treatment of a chronic depression: a case report].

Journal: L'Encephale 20040101

Title: Mood-stabilizers: the archeology of the concept.

Journal: Bipolar disorders 20031201

Title: Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.

Journal: Pharmaceutical research 20030801

Title: Valproate induces replication-independent active DNA demethylation.

Journal: The Journal of biological chemistry 20030725

Title: Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site.

Journal: The EMBO journal 20030602

Title: New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?

Journal: Current opinion in neurology 20030401

Title: Lupus-like syndrome and vasculitis induced by valpromide.

Journal: The Journal of rheumatology 20030101

Title: [The Charles Bonnet syndrome: a case report and a brief review].

Journal: Actas espanolas de psiquiatria 20030101

Title: [Severe oedema after valproate and valpromide].

Journal: Therapie 20020101

Title: Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide.

Journal: Therapeutic drug monitoring 20010801

Title: Clonic seizure associated with high clozapine plasma level.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20010101

Title: Valpromide increases amplitude of heart rate circadian rhythm in remitted bipolar and unipolar disorders. A placebo-controlled study.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20001101

Title: In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.

Journal: Pharmaceutical research 20001101

Title: [Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase].

Journal: Presse medicale (Paris, France : 1983) 19881105

Title: Pacifici GM, et al. Valpromide inhibits human epoxide hydrolase. Br J Clin Pharmacol. 1986 Sep;22(3):269-74.

Title: Gorres KL, et al. Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus. MBio. 2016 Mar 1;7(2):e00113.

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Tags:2430-27-5 Molecular Formula|2430-27-5 MDL|2430-27-5 SMILES|2430-27-5 2,2-DI-N-PROPYLACETAMIDE