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2437-79-8,MFCD00152835
Catalog No.:AA00BC5J

2437-79-8 | 2,2',4,4'-TETRACHLOROBIPHENYL

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25mg
2 weeks  
$319.00   $223.00
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  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BC5J
Chemical Name:
2,2',4,4'-TETRACHLOROBIPHENYL
CAS Number:
2437-79-8
Molecular Formula:
C12H6Cl4
Molecular Weight:
291.9880
MDL Number:
MFCD00152835
SMILES:
Clc1ccc(c(c1)Cl)c1ccc(cc1Cl)Cl
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
209  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Rotatable Bond Count:
1  
XLogP3:
6.3  

Literature

Title: Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently.

Journal: Toxicology and applied pharmacology 20150401

Title: Some OH-PCBs are more potent inhibitors of aromatase activity and (anti-) glucocorticoids than non-dioxin like (NDL)-PCBs and MeSO₂-PCBs.

Journal: Toxicology letters 20111010

Title: Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines.

Journal: Environmental research 20110401

Title: Serum PCB levels and congener profiles among teachers in PCB-containing schools: a pilot study.

Journal: Environmental health : a global access science source 20110101

Title: PCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABAA and alpha4beta2 nicotinic acetylcholine receptors.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201

Title: Activation and potentiation of human GABAA receptors by non-dioxin-like PCBs depends on chlorination pattern.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101101

Title: Changes in mitogen-activated protein kinase in cerebellar granule neurons by polybrominated diphenyl ethers and polychlorinated biphenyls.

Journal: Toxicology and applied pharmacology 20100515

Title: Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells.

Journal: Chemico-biological interactions 20091210

Title: Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro.

Journal: Environmental research 20080601

Title: Non-dioxin-like polychlorinated biphenyls induce a release of arachidonic acid in liver epithelial cells: a partial role of cytosolic phospholipase A(2) and extracellular signal-regulated kinases 1/2 signalling.

Journal: Toxicology 20080502

Title: Differential inhibition of hepatic microsomal alkoxyresorufin O-dealkylation activities by tetrachlorobiphenyls.

Journal: Chemico-biological interactions 20070815

Title: 2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB.

Journal: Toxicology and applied pharmacology 20070615

Title: Kinetic and mechanistic study of photodechlorination of 2,2',4,4'-tetrachlorobiphenyl in surfactant solutions.

Journal: Bulletin of environmental contamination and toxicology 20070201

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: The effect of chlorine substitution on the disposition of polychlorinated biphenyls following dermal administration.

Journal: Toxicology and applied pharmacology 20061001

Title: Chronic toxicity of 2,4,2',4'-tetrabromodiphenyl ether on the marine alga Skeletonema costatum and the crustacean Daphnia magna.

Journal: Environmental toxicology and chemistry 20060601

Title: Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Journal: Journal of medicinal chemistry 20050908

Title: Coplanar PCB congeners increase uterine weight and frontal cortical dopamine in the developing rat: implications for developmental neurotoxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050701

Title: Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050401

Title: Influence of a combination of two tetrachlorobiphenyl congeners (PCB 47; PCB 77) on thyroid status, choline acetyltransferase (ChAT) activity, and short- and long-term memory in 30-day-old Sprague-Dawley rats.

Journal: Toxicology 20041015

Title: Ortho-substituted but not coplanar PCBs rapidly kill cerebellar granule cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040501

Title: Spectral interactions of tetrachlorobiphenyls with hepatic microsomal cytochrome p450 enzymes.

Journal: Chemico-biological interactions 20031215

Title: Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

Journal: Chemical research in toxicology 20031001

Title: Influence of aeration on hydrophobic organic contaminant distribution and diffusive flux in estuarine sediments.

Journal: Environmental science & technology 20030815

Title: Effects of PCB congeners on the immune function of Mytilus hemocytes: alterations of tyrosine kinase-mediated cell signaling.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20030508

Title: Developmental exposure to polychlorinated biphenyls affects sexual behavior of rats.

Journal: Physiology & behavior 20020415

Title: Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens.

Journal: Chemical research in toxicology 20010301

Title: Behavioral effects following single and combined maternal exposure to PCB 77 (3,4,3',4'-tetrachlorobiphenyl) and PCB 47 (2,4,2',4'-tetrachlorobiphenyl) in rats.

Journal: Neurotoxicology and teratology 19990101

Title: Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.

Journal: Molecular pharmacology 19981201

Title: Inhibition of growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin in 5L rat hepatoma cells is associated with the presence of Ah receptor.

Journal: Carcinogenesis 19901201

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Tags:2437-79-8 Molecular Formula|2437-79-8 MDL|2437-79-8 SMILES|2437-79-8 2,2',4,4'-TETRACHLOROBIPHENYL |Organic_Building_Blocks