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244218-51-7,MFCD06198707
Catalog No.:AA00BF15

244218-51-7 | JTC-801

Pack Size
Purity
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Price(USD)
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1mg
98%
in stock  
$79.00   $55.00
- +
5mg
≥98%
in stock  
$82.00   $57.00
- +
10mg
≥98%
in stock  
$153.00   $107.00
- +
25mg
≥98%
in stock  
$356.00   $249.00
- +
50mg
≥98%
in stock  
$625.00   $437.00
- +
100mg
98%
in stock  
$1,106.00   $774.00
- +
500mg
98% by HPLC
in stock  
$3,439.00   $2,407.00
- +
1000mg
98% by HPLC
in stock  
$5,464.00   $3,825.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BF15
Chemical Name:
JTC-801
CAS Number:
244218-51-7
Molecular Formula:
C26H26ClN3O2
Molecular Weight:
447.9565
MDL Number:
MFCD06198707
SMILES:
CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C.Cl
Properties
Computed Properties
 
Complexity:
577  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  

Downstream Synthesis Route
Literature

Title: Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice.

Journal: Pharmacology, biochemistry, and behavior 20111001

Title: Synthesis and pharmacological evaluation of bivalent antagonists of the nociceptin opioid receptor.

Journal: European journal of medicinal chemistry 20110401

Title: Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.

Journal: British journal of pharmacology 20090701

Title: Opioid, cannabinoid CB1 and NOP receptors do not mediate APAP-induced hypothermia in rats.

Journal: Pharmacology, biochemistry, and behavior 20090501

Title: Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice.

Journal: Journal of anesthesia 20090101

Title: Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians.

Journal: Neuropeptides 20080601

Title: [Prostaglandin and nociceptin/orphanin FQ].

Journal: Masui. The Japanese journal of anesthesiology 20071101

Title: NOP receptor antagonist, JTC-801, blocks cannabinoid-evoked hypothermia in rats.

Journal: Neuropeptides 20070801

Title: The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.

Journal: The European journal of neuroscience 20060201

Title: Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation.

Journal: European journal of pharmacology 20050314

Title: A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists.

Journal: European journal of medicinal chemistry 20041201

Title: Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model.

Journal: Neuroscience letters 20031120

Title: Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.

Journal: The European journal of neuroscience 20030401

Title: Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801.

Journal: British journal of pharmacology 20020101

Title: 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.

Journal: Journal of medicinal chemistry 20001130

Title: Yamada H, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol, 2002, 135(2), 323-332.

Title: Koyama T, et al. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23(2):301-3.

Title: Shinkai H, et al. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem, 2000, 43(24), 4667-4677.

Title: Zhang Y, et al. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan;172(2):571-82.

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