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Title: Preventative oral methylthioadenosine is anti-inflammatory and reduces DSS-induced colitis in mice.
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Title: Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20060601
Title: Synthesis of a potent 5'-methylthioadenosine/S-adenosylhomocysteine (MTAN) inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20060515
Title: Methylthioadenosine and polyamine biosynthesis in a Saccharomyces cerevisiae meu1delta mutant.
Journal: Biochemical and biophysical research communications 20060428
Title: Development of high-throughput spermidine synthase activity assay using homogeneous time-resolved fluorescence.
Journal: Analytical biochemistry 20060415
Title: Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas.
Journal: Cancer genetics and cytogenetics 20060415
Title: Impact of quorum sensing on fitness of Pseudomonas aeruginosa.
Journal: International journal of medical microbiology : IJMM 20060401
Title: Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors.
Journal: Archives of dermatology 20060401
Title: Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma.
Journal: Archives of otolaryngology--head & neck surgery 20060401
Title: The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds.
Journal: Journal of molecular biology 20060317
Title: EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.
Journal: Blood 20060201
Title: Circadian pharmacology of L-alanosine (SDX-102) in mice.
Journal: Molecular cancer therapeutics 20060201
Title: Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma.
Journal: Carcinogenesis 20060101
Title: S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver.
Journal: Journal of applied toxicology : JAT 20060101
Title: Comparative protein modeling of spermidine synthase from Plasmodium falciparum: A potential target for anti-malarial drug therapy.
Journal: Bioinformation 20060101
Title: Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers.
Journal: Molecular cancer therapeutics 20051201
Title: Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implications.
Journal: The American journal of surgical pathology 20051101
Title: S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter.
Journal: The Journal of biological chemistry 20050902
Title: Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.
Journal: Journal of medicinal chemistry 20050714
Title: Concordant loss of MTAP and p16/CDKN2A expression in pancreatic intraepithelial neoplasia: evidence of homozygous deletion in a noninvasive precursor lesion.
Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20050701
Title: The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.
Journal: The Journal of biological chemistry 20050701
Title: Implications of P16/CDKN2A deletion in pleural mesotheliomas.
Journal: Lung cancer (Amsterdam, Netherlands) 20050701
Title: Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates.
Journal: Bioorganic & medicinal chemistry letters 20050602
Title: Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Journal: The Journal of biological chemistry 20050506
Title: Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli.
Journal: The Journal of biological chemistry 20050506
Title: A nucleosidase required for in vivo function of the S-adenosyl-L-methionine radical enzyme, biotin synthase.
Journal: Chemistry & biology 20050501
Title: Regulation of human methylthioadenosine phosphorylase gene by the CBF (CCAAT binding factor)/NF-Y (nuclear factor-Y).
Journal: The Biochemical journal 20050401
Title: Methylthioadenosine phosphorylase gene is silenced by promoter hypermethylation in human lymphoma cell line DHL-9: another mechanism of enzyme deficiency.
Journal: International journal of oncology 20050401
Title: Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa.
Journal: Biochemistry 20050301
Title: Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050120
Title: Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin.
Journal: Laboratory investigation; a journal of technical methods and pathology 20050101
Title: Bayesian phylogenetic analysis reveals two-domain topology of S-adenosylhomocysteine hydrolase protein sequences.
Journal: Molecular phylogenetics and evolution 20050101
Title: Comparative analysis of RNA regulatory elements of amino acid metabolism genes in Actinobacteria.
Journal: BMC microbiology 20050101
Title: Natural history of S-adenosylmethionine-binding proteins.
Journal: BMC structural biology 20050101
Title: Design and evaluation of 5'-modified nucleoside analogs as prodrugs for an E. coli purine nucleoside phosphorylase mutant.
Journal: Nucleosides, nucleotides & nucleic acids 20050101
Title: Functional analysis of methylthioribose kinase genes in plants.
Journal: Plant physiology 20041201
Title: Methylthioadenosine phosphorylase from the archaeon Pyrococcus furiosus. Mechanism of the reaction and assignment of disulfide bonds.
Journal: European journal of biochemistry 20041201
Title: Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma.
Journal: Biochimica et biophysica acta 20041105
Title: Methylthioadenosine.
Journal: The international journal of biochemistry & cell biology 20041101
Title: Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041101
Title: Comprehensive analysis of the 9p21 region in neuroblastoma suggests a role for genes mapping to 9p21-23 in the biology of favourable stage 4 tumours.
Journal: British journal of cancer 20040913
Title: Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits.
Journal: The Journal of biological chemistry 20040827
Title: Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20040801
Title: Analogs of 1-phosphonooxy-2,2-dihydroxy-3-oxo-5-(methylthio)pentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca.
Journal: Bioorganic & medicinal chemistry 20040715
Title: S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S).
Journal: Hepatology (Baltimore, Md.) 20040701
Title: Delivery systems and molecular targets of mechanism-based therapies for GBM.
Journal: Expert review of neurotherapeutics 20040701
Title: Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
Journal: The Journal of biological chemistry 20040625
Title: [Expression and clinical significance of methylthioadenosine phosphorylase gene in patients with non-small cell lung cancer].
Journal: Zhonghua yi xue za zhi 20040602
Title: Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations.
Journal: Free radical biology & medicine 20040515
Title: Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.
Journal: Journal of medicinal chemistry 20040422
Title: Synthesis and evaluation of analogues of S-adenosyl-L-methionine, as inhibitors of the E. coli cyclopropane fatty acid synthase.
Journal: Bioorganic & medicinal chemistry letters 20040405
Title: 5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.
Journal: Hepatology (Baltimore, Md.) 20040401
Title: Pharmacology and mechanism of action of pemetrexed.
Journal: Clinical lung cancer 20040401
Title: Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated kinases 1 and 2.
Journal: Circulation research 20040220
Title: Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.
Journal: Biochemistry 20040113
Title: Bacterial variations on the methionine salvage pathway.
Journal: BMC microbiology 20040101
Title: Status of methylthioadenosine phosphorylase and its impact on cellular response to L-alanosine and methylmercaptopurine riboside in human soft tissue sarcoma cells.
Journal: Oncology research 20040101
Title: Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis.
Journal: BMC microbiology 20040101
Title: Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites.
Journal: The Journal of biological chemistry 20031212
Title: Altered gene expression in liver from a murine model of hyperhomocysteinemia.
Journal: The Journal of biological chemistry 20030822
Title: Identification of gene expression profiles predicting tumor cell response to L-alanosine.
Journal: Biochemical pharmacology 20030815
Title: Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma.
Journal: The American journal of pathology 20030801
Title: Anaplerotic reactions in tumour proliferation and apoptosis.
Journal: Biochemical pharmacology 20030801
Title: Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030601
Title: CDKN2A, CDKN2B, and MTAP gene dosage permits precise characterization of mono- and bi-allelic 9p21 deletions in childhood acute lymphoblastic leukemia.
Journal: Genes, chromosomes & cancer 20030501
Title: Structure of Escherichia coli 5'-methylthioadenosine/ S-adenosylhomocysteine nucleosidase inhibitor complexes provide insight into the conformational changes required for substrate binding and catalysis.
Journal: The Journal of biological chemistry 20030307
Title: Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis.
Journal: BMC microbiology 20030101
Title: Modeling and experiment yields the structure of acireductone dioxygenase from Klebsiella pneumoniae.
Journal: Nature structural biology 20021201
Title: Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line.
Journal: Cancer research 20021115
Title: Chemotherapy targeting methylthioadenosine phosphorylase (MTAP) deficiency in adult T cell leukemia (ATL).
Journal: Leukemia 20020901
Title: S-adenosylmethionine conformations in solution and in protein complexes: conformational influences of the sulfonium group.
Journal: Biochemistry 20020618
Title: Deletion of dinucleotide repeat (Delta 14 allele) in the methylthioadenosine phosphorylase (MTAP) promoter and the allelotype of MTAP promoter in the Japanese population.
Journal: Japanese journal of cancer research : Gann 20020401
Title: Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020301
Title: S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers.
Journal: The Journal of biological chemistry 20020222
Title: S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.
Journal: Hepatology (Baltimore, Md.) 20020201
Title: Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides.
Journal: The Journal of biological chemistry 20020111
Title: Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells.
Journal: Blood cells, molecules & diseases 20020101
Title: The methionine salvage pathway in Bacillus subtilis.
Journal: BMC microbiology 20020101
Title: Isolation and properties of arginase from a shade plant, ginseng (Panax ginseng C.A. Meyer) roots.
Journal: Phytochemistry 20011201
Title: Glutamate 47 in 1-aminocyclopropane-1-carboxylate synthase is a major specificity determinant.
Journal: Biochemistry 20011016
Title: Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae.
Journal: Biochemistry 20010529
Title: Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription.
Journal: Cell 20010309
Title: 5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.
Journal: Journal of hepatology 20010301
Title: In situ kinetic characterization of methylthioadenosine transport by the adenosine transporter (P2) of the African Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense.
Journal: Biochemical pharmacology 20010215
Title: Expression, purification, crystallization and preliminary X-ray analysis of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.
Journal: Acta crystallographica. Section D, Biological crystallography 20010101
Title: Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in Bacillus subtilis.
Journal: Genome biology 20010101
Title: MtnK, methylthioribose kinase, is a starvation-induced protein in Bacillus subtilis.
Journal: BMC microbiology 20010101
Title: Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts.
Journal: Biochemical pharmacology 19940302
Title: Antimicrobial and antiviral activity of xylosyl-methylthio-adenosine, a naturally occurring analogue of methylthio-adenosine from Doris verrucosa.
Journal: Experientia 19911201
