Home Amines 246146-55-4
246146-55-4,MFCD09878236
Catalog No.:AA002OPL

246146-55-4 | Cyclopentaneacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-

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5mg
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1 week  
$289.00   $202.00
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10mg
99%
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$431.00   $302.00
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25mg
99%
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$812.00   $569.00
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50mg
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$1,273.00   $891.00
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002OPL
Chemical Name:
Cyclopentaneacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-
CAS Number:
246146-55-4
Molecular Formula:
C49H57N11O6
Molecular Weight:
896.0470
MDL Number:
MFCD09878236
SMILES:
NN=CNCCC[C@@H](C(=O)NCCn1c(=O)n(n(c1=O)c1ccccc1)c1ccccc1)NC(=O)CC1(CCCC1)CC(=O)N1CCN(CC1)C1c2ccccc2NC(=O)c2c1cccc2
Properties
Computed Properties
 
Complexity:
1710  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
66  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
16  
Undefined Atom Stereocenter Count:
1  
XLogP3:
3.8  

Literature

Title: Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20121201

Title: A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress.

Journal: British journal of pharmacology 20120801

Title: Role of Y(2) receptors in the regulation of gastric tone in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120401

Title: Role of neuropeptide Y Y₁ and Y₂ receptors on behavioral despair in a rat model of depression with co-morbid anxiety.

Journal: Neuropharmacology 20120101

Title: Distinct effects of NPY13-36, a specific NPY Y2 agonist, in a model of rodent endotoxemia on leukocyte subsets and cytokine levels.

Journal: Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20111220

Title: Attenuation of pain-related behavior evoked by injury through blockade of neuropeptide Y Y2 receptor.

Journal: Pain 20110501

Title: High expression of NPY receptors in the human testis.

Journal: Molecular and cellular endocrinology 20110430

Title: Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy.

Journal: Oncogene 20101014

Title: Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions.

Journal: Regulatory peptides 20100809

Title: Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening.

Journal: Molecular pharmacology 20100101

Title: Peripheral peptide YY inhibits propulsive colonic motor function through Y2 receptor in conscious mice.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100101

Title: Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear.

Journal: Neuroscience 20091229

Title: The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090801

Title: Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

Title: Different regulation of atrial ANP release through neuropeptide Y2 and Y4 receptors.

Journal: Journal of Korean medical science 20081201

Title: Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum.

Journal: Molecular and cellular neurosciences 20081001

Title: Endogenous PYY and NPY mediate tonic Y1- and Y2-mediated absorption in human and mouse colon.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20080901

Title: Neuropeptide Y receptors in primary human brain tumors: overexpression in high-grade tumors.

Journal: Journal of neuropathology and experimental neurology 20080801

Title: Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway.

Journal: Journal of molecular and cellular cardiology 20080301

Title: Role of CCK1 and Y2 receptors in activation of hindbrain neurons induced by intragastric administration of bitter taste receptor ligands.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080101

Title: NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning.

Journal: Hippocampus 20080101

Title: Oligomerization of neuropeptide Y (NPY) Y2 receptors in CHO cells depends on functional pertussis toxin-sensitive G-proteins.

Journal: Regulatory peptides 20071204

Title: Sigma 1 receptor-mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y.

Journal: The European journal of neuroscience 20071201

Title: A novel long-acting selective neuropeptide Y2 receptor polyethylene glycol-conjugated peptide agonist reduces food intake and body weight and improves glucose metabolism in rodents.

Journal: The Journal of pharmacology and experimental therapeutics 20071101

Title: Selective role of neuropeptide Y receptor subtype Y2 in the control of gonadotropin secretion in the rat.

Journal: American journal of physiology. Endocrinology and metabolism 20071101

Title: Neuropeptide Y-induced enhancement of the evoked release of newly synthesized dopamine in rat striatum: mediation by Y2 receptors.

Journal: Neuropharmacology 20070501

Title: Infusion of neuropeptide Y into CA3 region of hippocampus produces antidepressant-like effect via Y1 receptor.

Journal: Hippocampus 20070101

Title: Neuropeptide Y regulates recurrent mossy fiber synaptic transmission less effectively in mice than in rats: Correlation with Y2 receptor plasticity.

Journal: Neuroscience 20061228

Title: Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y2 receptor ligands.

Journal: European journal of pharmacology 20061203

Title: Anxiolytic-like effect of the selective neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze.

Journal: Peptides 20061201

Title: Ventricular fibrillation induced by ischemia-reperfusion is not prevented by the NPY Y2 receptor antagonist BIIE0246.

Journal: Journal of cardiovascular pharmacology and therapeutics 20060901

Title: Neuropeptide Y2 receptors are involved in enhanced neurogenic vasoconstriction in spontaneously hypertensive rats.

Journal: British journal of pharmacology 20060701

Title: Irreversible binding kinetics of neuropeptide Y ligands to Y2 but not to Y1 and Y5 receptors.

Journal: Pharmacology 20051201

Title: Neuropeptide Y bioavailability is suppressed in the hindlimb of female Sprague-Dawley rats.

Journal: The Journal of physiology 20051015

Title: Influence of endogenous neuropeptide Y (NPY) on the sympathetic-parasympathetic interaction in the canine heart.

Journal: Journal of cardiovascular pharmacology 20051001

Title: The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors.

Journal: The European journal of neuroscience 20050901

Title: Intravenous peptide YY3-36 and Y2 receptor antagonism in the rat: effects on feeding behaviour.

Journal: Journal of neuroendocrinology 20050701

Title: Blockade of the neuropeptide Y Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake.

Journal: Brain research 20050510

Title: Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence.

Journal: Neuroscience letters 20050227

Title: Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

Title: Differential expression of Y receptors and signaling pathways in intestinal circular and longitudinal smooth muscle.

Journal: Regulatory peptides 20050215

Title: Endogenous neuropeptide Y depresses the afferent signaling of gastric acid challenge to the mouse brainstem via neuropeptide Y type Y2 and Y4 receptors.

Journal: Neuroscience 20050101

Title: Neuropeptide Y inhibits acetylcholine release in human heart atrium by activation of Y2-receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040501

Title: Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin.

Journal: Neuroscience 20040101

Title: Stimulation of neurons in rat ARC inhibits gastric acid secretion via hypothalamic CRF1/2- and NPY-Y1 receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031201

Title: Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]NPY.

Journal: British journal of pharmacology 20030801

Title: Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.

Journal: British journal of pharmacology 20030601

Title: Functional interaction between neuropeptide Y receptors and modulation of calcium channels in the rat hippocampus.

Journal: Neuropharmacology 20030201

Title: Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021115

Title: Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats.

Journal: Neuroscience letters 20021025

Title: Blockade of neuropeptide Y(2) receptors and suppression of NPY's anti-epileptic actions in the rat hippocampal slice by BIIE0246.

Journal: British journal of pharmacology 20020601

Title: Antagonistic interaction between BIIE 0246, a neuropeptide Y Y2-receptor antagonist, and omega-conotoxin GVIA, a Ca2+ channel antagonist, in presynaptic transmitter releases in dog splenic arteries.

Journal: Japanese journal of pharmacology 20020601

Title: Reciprocal mutations of neuropeptide Y receptor Y2 in human and chicken identify amino acids important for antagonist binding.

Journal: FEBS letters 20020508

Title: The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20020501

Title: Neuropeptide Y inhibits double peaked vasoconstrictor responses to periarterial nerve stimulation primarily through prejunctional Y2 receptor subtype in canine splenic arteries.

Journal: Autonomic & autacoid pharmacology 20020401

Title: Autoinhibitory function of the sympathetic prejunctional neuropeptide Y Y(2) receptor evidenced by BIIE0246.

Journal: European journal of pharmacology 20020329

Title: Role of neuropeptide Y Y(2) receptors in modulation of cardiac parasympathetic neurotransmission.

Journal: Regulatory peptides 20020215

Title: Effects of the neuropeptide Y Y2 receptor antagonist BIIE0246 on sympathetic transmitter release in the pig in vivo.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020201

Title: Brain neuropeptide Y (NPY) in stress and alcohol dependence.

Journal: Reviews in the neurosciences 20020101

Title: Involvement of NPY Y2 receptor subtype in the control of the spontaneous NO/GnRH release at the rat median eminence.

Journal: Neuroreport 20011029

Title: Existence of both neuropeptide Y, Y1 and Y2 receptors in pig spleen: evidence using subtype-selective antagonists in vivo.

Journal: Life sciences 20010914

Title: Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y(2) receptor antagonist, in vivo.

Journal: British journal of pharmacology 20010801

Title: The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.

Journal: Molecular pharmacology 20010701

Title: Effects of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246, on Y2 receptors at peripheral neuroeffector junctions.

Journal: British journal of pharmacology 20010201

Title: BIIE0246: a selective and high affinity neuropeptide Y Y(2) receptor antagonist.

Journal: European journal of pharmacology 19991119

Title: Dumont Y, et al. BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. Br J Pharmacol. 2000 Mar;129(6):1075-88.

Title: Liisa Ailanen, et al. Peripherally Administered Y2-Receptor Antagonist BIIE0246 Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but Enhances Obesity in Control Mice. Front Pharmacol. 2018; 9: 319.

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Tags:246146-55-4 Molecular Formula|246146-55-4 MDL|246146-55-4 SMILES|246146-55-4 Cyclopentaneacetamide, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-