Home Fluorides 246246-19-5
246246-19-5,MFCD04039992
Catalog No.:AA002ORI

246246-19-5 | 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$150.00   $105.00
- +
5mg
≥98%
in stock  
$656.00   $459.00
- +
10mg
≥98%
in stock  
$1,166.00   $816.00
- +
25mg
98% by HPLC
in stock  
$2,488.00   $1,742.00
- +
50mg
98% by HPLC
in stock  
$4,197.00   $2,938.00
- +
100mg
98% by HPLC
in stock  
$7,217.00   $5,052.00
- +
500mg
98% by HPLC
in stock  
$23,165.00   $16,216.00
- +
1000mg
98% by HPLC
in stock  
$37,032.00   $25,922.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002ORI
Chemical Name:
5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-
CAS Number:
246246-19-5
Molecular Formula:
C24H31FO4
Molecular Weight:
402.4989
MDL Number:
MFCD04039992
SMILES:
OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F
Properties
Computed Properties
 
Complexity:
575  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
3.7  

Literature

Title: The dietary fatty acid 10E12Z-CLA induces epiregulin expression through COX-2 dependent PGF(2α) synthesis in adipocytes.

Journal: Prostaglandins & other lipid mediators 20121001

Title: Prostaglandin FP receptor inhibitor reduces ischemic brain damage and neurotoxicity.

Journal: Neurobiology of disease 20121001

Title: Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²⁺]i increases in human trabecular meshwork and smooth muscle.

Journal: Investigative ophthalmology & visual science 20120807

Title: Discovery of prostamide F2α and its role in inflammatory pain and dorsal horn nociceptive neuron hyperexcitability.

Journal: PloS one 20120101

Title: Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression.

Journal: Prostaglandins & other lipid mediators 20110401

Title: Suppression of adipocyte differentiation by aldo-keto reductase 1B3 acting as prostaglandin F2alpha synthase.

Journal: The Journal of biological chemistry 20100319

Title: Cyclic AMP-mediated chloride secretion is induced by prostaglandin F2alpha in human isolated colon.

Journal: British journal of pharmacology 20091201

Title: Involvement of prostaglandin F 2 alpha receptor in ATP-induced mechanical allodynia.

Journal: Neuroscience 20090929

Title: Regulation of ANP secretion from isolated atria by prostaglandins and cyclooxygenase-2.

Journal: Peptides 20090901

Title: COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090201

Title: Prostaglandin E2 and F2alpha activate the FP receptor and up-regulate cyclooxygenase-2 expression via the cyclic AMP response element.

Journal: Molecular and cellular endocrinology 20080326

Title: Synthetic FP-prostaglandin-induced contraction of rat uterus smooth muscle in vitro.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20080301

Title: Involvement of endogenous prostaglandin F2alpha on kainic acid-induced seizure activity through FP receptor: the mechanism of proconvulsant effects of COX-2 inhibitors.

Journal: Brain research 20080208

Title: Identification of an antagonist that selectively blocks the activity of prostamides (prostaglandin-ethanolamides) in the feline iris.

Journal: British journal of pharmacology 20070201

Title: Mechanisms regulating spontaneous contractions in the bovine epididymal duct.

Journal: Biology of reproduction 20061001

Title: Endothelin antagonism: effects of FP receptor agonists prostaglandin F2alpha and fluprostenol on trabecular meshwork contractility.

Journal: Investigative ophthalmology & visual science 20060301

Title: Vasoactive responses of U46619, PGF2alpha, latanoprost, and travoprost in isolated porcine ciliary arteries.

Journal: Investigative ophthalmology & visual science 20060101

Title: Human trabecular meshwork cell responses induced by bimatoprost, travoprost, unoprostone, and other FP prostaglandin receptor agonist analogues.

Journal: Investigative ophthalmology & visual science 20030201

Title: Real-time intracellular Ca2+ mobilization by travoprost acid, bimatoprost, unoprostone, and other analogs via endogenous mouse, rat, and cloned human FP prostaglandin receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20030101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Bimatoprost and its free acid are prostaglandin FP receptor agonists.

Journal: European journal of pharmacology 20011207

Title: AL-8810: a novel prostaglandin F2 alpha analog with selective antagonist effects at the prostaglandin F2 alpha (FP) receptor.

Journal: The Journal of pharmacology and experimental therapeutics 19990901

Title: Biasing the prostaglandin F2α receptor responses toward EGFR-dependent transactivation of MAPK.

Journal: Molecular endocrinology (Baltimore, Md.)

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 246246-19-5
Tags:246246-19-5 Molecular Formula|246246-19-5 MDL|246246-19-5 SMILES|246246-19-5 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-