24729-96-2,MFCD11982855
Catalog No.:AA003OXU

24729-96-2 | Clindamycin Phosphate

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5g
98%(HPLC)
in stock  
$61.00   $43.00
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25g
≥ 780 µg/mg (Assay, anhydrous basis)
in stock  
$180.00   $126.00
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100g
≥ 780 µg/mg (Assay, anhydrous basis)
in stock  
$448.00   $314.00
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250g
≥ 780 µg/mg (Assay, anhydrous basis)
in stock  
$687.00   $481.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003OXU
Chemical Name:
Clindamycin Phosphate
CAS Number:
24729-96-2
Molecular Formula:
C18H34ClN2O8PS
Molecular Weight:
504.9629
MDL Number:
MFCD11982855
SMILES:
CCCC1CN(C(C1)C(=O)NC(C1OC(SC)C(C(C1O)O)OP(=O)(O)O)C(Cl)C)C
Properties
Properties
 
Form:
Solid  
MP:
187-192°C (dec.)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
658  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-1.2  

Literature

Title: Enantioseparation of chiral acids and bases on a clindamycin phosphate-modified zirconia monolith by capillary electrochromatography.

Journal: Journal of chromatography. A 20120817

Title: Combination effects of cosmetic moisturisers in the topical treatment of acne vulgaris.

Journal: The Journal of dermatological treatment 20120601

Title: Pharmacokinetics of clindamycin in the plasma and dialysate after intraperitoneal administration of clindamycin phosphoester to patients on continuous ambulatory peritoneal dialysis: an open-label, prospective, single-dose, two-institution study.

Journal: Basic & clinical pharmacology & toxicology 20120601

Title: A mechanistic study on the effect of ethanol and importance of water on permeation of drugs through human third-degree burn eschar.

Journal: International wound journal 20120401

Title: Efficacy and safety of clindamycin-tretinoin gel versus clindamycin or tretinoin alone in acne vulgaris: a randomized, double-blind, vehicle-controlled study.

Journal: Journal of drugs in dermatology : JDD 20120301

Title: Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris.

Journal: The Journal of dermatological treatment 20120201

Title: Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20110301

Title: Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate).

Journal: Colloids and surfaces. B, Biointerfaces 20110201

Title: Assemblage of drug release modules: effect of module shape and position in the assembled systems on floating behavior and release rate.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110101

Title: [Isolation and identification of impurities from raw material of clindamycin phosphate].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20101101

Title: Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro.

Journal: Journal of enzyme inhibition and medicinal chemistry 20101001

Title: Evaluation of the enantioseparation capability of the novel chiral selector clindamycin phosphate towards basic drugs by micellar electrokinetic chromatography.

Journal: Journal of chromatography. A 20100312

Title: Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clindamycin phosphate.

Journal: Pharmaceutical development and technology 20100101

Title: Investigation of enantiomeric separation of basic drugs by capillary electrophoresis using clindamycin phosphate as a novel chiral selector.

Journal: Electrophoresis 20090801

Title: Efficacy and tolerability of a fixed combination of clindamycin phosphate (1.2%) and low concentration benzoyl peroxide (2.5%) aqueous gel in moderate or severe acne subpopulations.

Journal: Journal of drugs in dermatology : JDD 20090801

Title: Physicochemical characterization and skin permeation of liposome formulations containing clindamycin phosphate.

Journal: Archives of pharmacal research 20090701

Title: [Determination of content and entrapment efficiency of clindamycin phosphate liposome].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20090601

Title: Separation and characterization of clindamycin phosphate and related impurities in injection by liquid chromatography/electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20090301

Title: Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial.

Journal: Indian journal of dermatology, venereology and leprology 20090101

Title: A novel gel formulation of 0.25% tretinoin and 1.2% clindamycin phosphate: efficacy in acne vulgaris patients aged 12 to 18 years.

Journal: Pediatric dermatology 20090101

Title: Picture of the month. Staphylococcal scalded skin syndrome.

Journal: Archives of pediatrics & adolescent medicine 20081201

Title: An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients.

Journal: Journal of the American Academy of Dermatology 20081101

Title: Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris.

Journal: Expert opinion on pharmacotherapy 20081101

Title: Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080501

Title: Clindamycin phosphate 1.2%- tretinoin 0.025% gel: vehicle characteristics, stability, and tolerability.

Journal: Cutis 20080501

Title: Clindamycin phosphate scavenges hydroxyl radical.

Journal: International journal of dermatology 20071101

Title: Lethal drug probe in China: the case of Xinfu clindamycin.

Journal: Pharmacoepidemiology and drug safety 20070801

Title: Enhancement of the skin permeation of clindamycin phosphate by Aerosol OT/1-butanol microemulsions.

Journal: Drug development and industrial pharmacy 20070801

Title: Physico-chemical characterisation of different clindamycin phosphate samples.

Journal: Bosnian journal of basic medical sciences 20070501

Title: Ziana (clindamycin phosphate 1.2% and tretinoin 0.025%)gel.

Journal: Skinmed 20070101

Title: Clindamycin phosphate plus tretinoin 1.2%/0.025% gel (Ziana) for acne.

Journal: Skinmed 20070101

Title: Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies.

Journal: Indian journal of dermatology, venereology and leprology 20070101

Title: Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo.

Journal: Biological & pharmaceutical bulletin 20060801

Title: Bioequivalence study of clindamycin phosphate injection (Clinott-P) in Thai healthy volunteers.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060501

Title: Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial.

Journal: The British journal of dermatology 20060301

Title: The clinical impact of vehicle technology using a patented formulation of benzoyl peroxide 5%/clindamycin 1% gel: comparative assessments of skin tolerability and evaluation of combination use with a topical retinoid.

Journal: Journal of drugs in dermatology : JDD 20060201

Title: An open-label, two-period, crossover study of the systemic bioavailability in healthy women of clindamycin phosphate from two vaginal cream formulations.

Journal: Clinical therapeutics 20051201

Title: The efficacy and safety of a single dose of Clindesse vaginal cream versus a seven-dose regimen of Cleocin vaginal cream in patients with bacterial vaginosis.

Journal: Infectious diseases in obstetrics and gynecology 20050901

Title: Intraosseous injection of clindamycin phosphate into the chronic apical lesion of lower molar--a case report.

Journal: Bosnian journal of basic medical sciences 20050501

Title: EVOCLIN (clindamycin phosphate foam, 1%).

Journal: Skinmed 20050101

Title: Brand confusion causes allergic dermatitis.

Journal: Journal of postgraduate medicine 20050101

Title: Simultaneous determination of tretinoin and clindamycin phosphate and their degradation products in topical formulations by reverse phase HPLC.

Journal: Journal of separation science 20040101

Title: Clindoxyl gel for the treatment of acne vulgaris.

Journal: Skin therapy letter 20020501

Title: Comparison of clindamycin phosphate vaginal cream with triple sulfonamide vaginal cream in the treatment of bacterial vaginosis.

Journal: Sexually transmitted diseases 20011001

Title: Activation of clindamycin phosphate by human skin.

Journal: Journal of applied microbiology 20010401

Title: Clindamycin phosphate 1% gel in acne vulgaris.

Journal: Advances in therapy 20010101

Title: In vivo assessment of antimicrobial agents against Toxoplasma gondii by quantification of parasites in the blood, lungs, and brain of infected mice.

Journal: Antimicrobial agents and chemotherapy 19900801

Title: [Cardiac arrest induced by intravenous administration of clindamycin phosphate. Description of a clinical case].

Journal: Minerva anestesiologica 19830901

Title: Clindamycin-induced cardiac arrest.

Journal: Southern medical journal 19820601

Title: Nafcillin-associated hypokalemia.

Journal: JAMA 19790810

Title: Treatment of Bacteroides infection with clindamycin-2-phosphate.

Journal: Canadian Medical Association journal 19741102

Title: Li H, et al. Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system. Eur J Clin Pharmacol. 2017 Feb;73(2):251-253.

Title: Hayashi N, et al. Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed-dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator-blind, parallel-group study. J Dermatol. 2018 Aug;45(8):951-962.

Title: A. Dupre, et al. Proof of concept study of a novel bioadhesive clindamycin phosphate 2% vaginal gel to treat bacterial vaginosis. Clin. Exp. Obstet. Gynecol. 2020, 47(4), 516–518

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SDS
Tags:24729-96-2 Molecular Formula|24729-96-2 MDL|24729-96-2 SMILES|24729-96-2 Clindamycin Phosphate
Catalog No.: AA003OXU
24729-96-2,MFCD11982855
24729-96-2 | Clindamycin Phosphate
Pack Size: 5g
Purity: 98%(HPLC)
in stock
$61.00 $43.00
Pack Size: 25g
Purity: ≥ 780 µg/mg (Assay, anhydrous basis)
in stock
$180.00 $126.00
Pack Size: 100g
Purity: ≥ 780 µg/mg (Assay, anhydrous basis)
in stock
$448.00 $314.00
Pack Size: 250g
Purity: ≥ 780 µg/mg (Assay, anhydrous basis)
in stock
$687.00 $481.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003OXU
Chemical Name: Clindamycin Phosphate
CAS Number: 24729-96-2
Molecular Formula: C18H34ClN2O8PS
Molecular Weight: 504.9629
MDL Number: MFCD11982855
SMILES: CCCC1CN(C(C1)C(=O)NC(C1OC(SC)C(C(C1O)O)OP(=O)(O)O)C(Cl)C)C
Properties
Form: Solid  
MP: 187-192°C (dec.)  
Storage: Keep in dry area;2-8℃;  
Complexity: 658  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 9  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 10  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 9  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -1.2  
Literature fold

Title: Enantioseparation of chiral acids and bases on a clindamycin phosphate-modified zirconia monolith by capillary electrochromatography.

Journal: Journal of chromatography. A20120817

Title: Combination effects of cosmetic moisturisers in the topical treatment of acne vulgaris.

Journal: The Journal of dermatological treatment20120601

Title: Pharmacokinetics of clindamycin in the plasma and dialysate after intraperitoneal administration of clindamycin phosphoester to patients on continuous ambulatory peritoneal dialysis: an open-label, prospective, single-dose, two-institution study.

Journal: Basic & clinical pharmacology & toxicology20120601

Title: A mechanistic study on the effect of ethanol and importance of water on permeation of drugs through human third-degree burn eschar.

Journal: International wound journal20120401

Title: Efficacy and safety of clindamycin-tretinoin gel versus clindamycin or tretinoin alone in acne vulgaris: a randomized, double-blind, vehicle-controlled study.

Journal: Journal of drugs in dermatology : JDD20120301

Title: Effect of sequential application of topical adapalene and clindamycin phosphate in the treatment of Japanese patients with acne vulgaris.

Journal: The Journal of dermatological treatment20120201

Title: Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20110301

Title: Poly(D,L-lactide-co-glycolide)/hydroxyapatite core-shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate).

Journal: Colloids and surfaces. B, Biointerfaces20110201

Title: Assemblage of drug release modules: effect of module shape and position in the assembled systems on floating behavior and release rate.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V20110101

Title: [Isolation and identification of impurities from raw material of clindamycin phosphate].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20101101

Title: Differential effects of some antibiotics on paraoxonase enzyme activity on human hepatoma cells (HepG2) in vitro.

Journal: Journal of enzyme inhibition and medicinal chemistry20101001

Title: Evaluation of the enantioseparation capability of the novel chiral selector clindamycin phosphate towards basic drugs by micellar electrokinetic chromatography.

Journal: Journal of chromatography. A20100312

Title: Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clindamycin phosphate.

Journal: Pharmaceutical development and technology20100101

Title: Investigation of enantiomeric separation of basic drugs by capillary electrophoresis using clindamycin phosphate as a novel chiral selector.

Journal: Electrophoresis20090801

Title: Efficacy and tolerability of a fixed combination of clindamycin phosphate (1.2%) and low concentration benzoyl peroxide (2.5%) aqueous gel in moderate or severe acne subpopulations.

Journal: Journal of drugs in dermatology : JDD20090801

Title: Physicochemical characterization and skin permeation of liposome formulations containing clindamycin phosphate.

Journal: Archives of pharmacal research20090701

Title: [Determination of content and entrapment efficiency of clindamycin phosphate liposome].

Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi20090601

Title: Separation and characterization of clindamycin phosphate and related impurities in injection by liquid chromatography/electrospray ionization mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20090301

Title: Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial.

Journal: Indian journal of dermatology, venereology and leprology20090101

Title: A novel gel formulation of 0.25% tretinoin and 1.2% clindamycin phosphate: efficacy in acne vulgaris patients aged 12 to 18 years.

Journal: Pediatric dermatology20090101

Title: Picture of the month. Staphylococcal scalded skin syndrome.

Journal: Archives of pediatrics & adolescent medicine20081201

Title: An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate to severe acne vulgaris: assessment of efficacy and safety in 2813 patients.

Journal: Journal of the American Academy of Dermatology20081101

Title: Clindamycin phosphate/tretinoin gel formulation in the treatment of acne vulgaris.

Journal: Expert opinion on pharmacotherapy20081101

Title: Efficacy and tolerability of clindamycin phosphate and salicylic acid gel in the treatment of mild to moderate acne vulgaris.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV20080501

Title: Clindamycin phosphate 1.2%- tretinoin 0.025% gel: vehicle characteristics, stability, and tolerability.

Journal: Cutis20080501

Title: Clindamycin phosphate scavenges hydroxyl radical.

Journal: International journal of dermatology20071101

Title: Lethal drug probe in China: the case of Xinfu clindamycin.

Journal: Pharmacoepidemiology and drug safety20070801

Title: Enhancement of the skin permeation of clindamycin phosphate by Aerosol OT/1-butanol microemulsions.

Journal: Drug development and industrial pharmacy20070801

Title: Physico-chemical characterisation of different clindamycin phosphate samples.

Journal: Bosnian journal of basic medical sciences20070501

Title: Ziana (clindamycin phosphate 1.2% and tretinoin 0.025%)gel.

Journal: Skinmed20070101

Title: Clindamycin phosphate plus tretinoin 1.2%/0.025% gel (Ziana) for acne.

Journal: Skinmed20070101

Title: Adapalene pretreatment increases follicular penetration of clindamycin: in vitro and in vivo studies.

Journal: Indian journal of dermatology, venereology and leprology20070101

Title: Effects of some antibiotics on paraoxonase from human serum in vitro and from mouse serum and liver in vivo.

Journal: Biological & pharmaceutical bulletin20060801

Title: Bioequivalence study of clindamycin phosphate injection (Clinott-P) in Thai healthy volunteers.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet20060501

Title: Conjoint analysis: a novel, rigorous tool for determining patient preferences for topical antibiotic treatment for acne. A randomised controlled trial.

Journal: The British journal of dermatology20060301

Title: The clinical impact of vehicle technology using a patented formulation of benzoyl peroxide 5%/clindamycin 1% gel: comparative assessments of skin tolerability and evaluation of combination use with a topical retinoid.

Journal: Journal of drugs in dermatology : JDD20060201

Title: An open-label, two-period, crossover study of the systemic bioavailability in healthy women of clindamycin phosphate from two vaginal cream formulations.

Journal: Clinical therapeutics20051201

Title: The efficacy and safety of a single dose of Clindesse vaginal cream versus a seven-dose regimen of Cleocin vaginal cream in patients with bacterial vaginosis.

Journal: Infectious diseases in obstetrics and gynecology20050901

Title: Intraosseous injection of clindamycin phosphate into the chronic apical lesion of lower molar--a case report.

Journal: Bosnian journal of basic medical sciences20050501

Title: EVOCLIN (clindamycin phosphate foam, 1%).

Journal: Skinmed20050101

Title: Brand confusion causes allergic dermatitis.

Journal: Journal of postgraduate medicine20050101

Title: Simultaneous determination of tretinoin and clindamycin phosphate and their degradation products in topical formulations by reverse phase HPLC.

Journal: Journal of separation science20040101

Title: Clindoxyl gel for the treatment of acne vulgaris.

Journal: Skin therapy letter20020501

Title: Comparison of clindamycin phosphate vaginal cream with triple sulfonamide vaginal cream in the treatment of bacterial vaginosis.

Journal: Sexually transmitted diseases20011001

Title: Activation of clindamycin phosphate by human skin.

Journal: Journal of applied microbiology20010401

Title: Clindamycin phosphate 1% gel in acne vulgaris.

Journal: Advances in therapy20010101

Title: In vivo assessment of antimicrobial agents against Toxoplasma gondii by quantification of parasites in the blood, lungs, and brain of infected mice.

Journal: Antimicrobial agents and chemotherapy19900801

Title: [Cardiac arrest induced by intravenous administration of clindamycin phosphate. Description of a clinical case].

Journal: Minerva anestesiologica19830901

Title: Clindamycin-induced cardiac arrest.

Journal: Southern medical journal19820601

Title: Nafcillin-associated hypokalemia.

Journal: JAMA19790810

Title: Treatment of Bacteroides infection with clindamycin-2-phosphate.

Journal: Canadian Medical Association journal19741102

Title: Li H, et al. Clindamycin hydrochloride and clindamycin phosphate: two drugs or one? A retrospective analysis of a spontaneous reporting system. Eur J Clin Pharmacol. 2017 Feb;73(2):251-253.

Title: Hayashi N, et al. Clindamycin phosphate 1.2%/benzoyl peroxide 3% fixed-dose combination gel versus topical combination therapy of adapalene 0.1% gel and clindamycin phosphate 1.2% gel in the treatment of acne vulgaris in Japanese patients: A multicenter, randomized, investigator-blind, parallel-group study. J Dermatol. 2018 Aug;45(8):951-962.

Title: A. Dupre, et al. Proof of concept study of a novel bioadhesive clindamycin phosphate 2% vaginal gel to treat bacterial vaginosis. Clin. Exp. Obstet. Gynecol. 2020, 47(4), 516–518

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