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248919-64-4,MFCD30343852
Catalog No.:AA00BF4F

248919-64-4 | Azd0865

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$58.00   $40.00
- +
5mg
≥98%
in stock  
$255.00   $178.00
- +
10mg
≥98%
in stock  
$450.00   $315.00
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25mg
≥98%
in stock  
$985.00   $689.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BF4F
Chemical Name:
Azd0865
CAS Number:
248919-64-4
Molecular Formula:
C21H26N4O2
Molecular Weight:
366.4567
MDL Number:
MFCD30343852
SMILES:
OCCNC(=O)c1cc(NCc2c(C)cccc2C)c2n(c1)c(C)c(n2)C
Properties
Computed Properties
 
Complexity:
493  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.4  

Literature

Title: Regurgitation is less responsive to acid suppression than heartburn in patients with gastroesophageal reflux disease.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20120601

Title: Evaluation of basic, heterocyclic ring systems as templates for use as potassium competitive acid blockers (pCABs).

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).

Journal: Bioorganic & medicinal chemistry letters 20090701

Title: A randomized, comparative trial of a potassium-competitive acid blocker (AZD0865) and esomeprazole for the treatment of patients with nonerosive reflux disease.

Journal: The American journal of gastroenterology 20080101

Title: New pharmacological agents for the treatment of gastroesophageal reflux disease.

Journal: Reviews in gastroenterological disorders 20080101

Title: [Therapeutic innovations in gastroesophageal reflux].

Journal: Presse medicale (Paris, France : 1983) 20071201

Title: A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20071201

Title: Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase.

Journal: Biochemical pharmacology 20070115

Title: Characteristics of the K+-competitive H+,K+-ATPase inhibitor AZD0865 in isolated rat gastric glands.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20061101

Title: Gedda K et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase.Biochem Pharmacol. 2007 Jan 15;73(2):198-205.

Title: Kahrilas PJ et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol. 2007 Dec;5(12):1385-91.

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