Home Other Building Blocks 24939-03-5
24939-03-5,MFCD00131957
Catalog No.:AA00I4OV

24939-03-5 | 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acidhomopolymer (1:1)OTHER CA INDEX NAMES:5'-Cytidylic acid, homopolymer, complex with 5'-inosinic acidhomopolymer (1:1)

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100mg
90+%
in stock  
$111.00   $78.00
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250mg
90+%
in stock  
$147.00   $103.00
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1g
90+%
in stock  
$272.00   $190.00
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5g
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$754.00   $528.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I4OV
Chemical Name:
5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acidhomopolymer (1:1)OTHER CA INDEX NAMES:5'-Cytidylic acid, homopolymer, complex with 5'-inosinic acidhomopolymer (1:1)
CAS Number:
24939-03-5
Molecular Formula:
C19H27N7O16P2
Molecular Weight:
671.4025
MDL Number:
MFCD00131957
SMILES:
O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1nc[nH]c2=O)COP(=O)(O)O.Nc1ccn(c(=O)n1)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(O)O
Properties
Computed Properties
 
Complexity:
1090  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
18  
Hydrogen Bond Donor Count:
10  
Rotatable Bond Count:
8  

Literature

Title: Involvement of estrogen receptor α in pro-pruritic and pro-inflammatory responses in a mouse model of allergic dermatitis.

Journal: Toxicology and applied pharmacology 20180915

Title: Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity.

Journal: The Science of the total environment 20180101

Title: Diesel exhaust particulate associated chemicals attenuate expression of CXCL10 in human primary bronchial epithelial cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20171201

Title: Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170901

Title: Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells.

Journal: Archives of toxicology 20170501

Title: Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20170201

Title: Vitamin D treatment during pregnancy prevents autism-related phenotypes in a mouse model of maternal immune activation.

Journal: Molecular autism 20170101

Title: Upregulation of the cannabinoid CB2 receptor in environmental and viral inflammation-driven rat models of Parkinson's disease.

Journal: Experimental neurology 20160901

Title: Intracellular RIG-I Signaling Regulates TLR4-Independent Endothelial Inflammatory Responses to Endotoxin.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20160601

Title: Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20160101

Title: Dental metal-induced innate reactivity in keratinocytes.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151225

Title: Cytokine responses induced by diesel exhaust particles are suppressed by PAR-2 silencing and antioxidant treatment, and driven by polar and non-polar soluble constituents.

Journal: Toxicology letters 20151014

Title: The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors.

Journal: The Journal of biological chemistry 20150807

Title: Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150401

Title: Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury).

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150301

Title: Toll like receptor-3 priming alters diesel exhaust particle-induced cytokine responses in human bronchial epithelial cells.

Journal: Toxicology letters 20140703

Title: Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20140617

Title: MicroRNA-26a negatively regulates toll-like receptor 3 expression of rat macrophages and ameliorates pristane induced arthritis in rats.

Journal: Arthritis research & therapy 20140101

Title: Sodium methyldithiocarbamate exerts broad inhibition of cellular signaling and expression of effector molecules of inflammation.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201

Title: Role of drug-independent stress factors in liver injury associated with diclofenac intake.

Journal: Toxicology 20131004

Title: Suppressive effects of antimycotics on thymic stromal lymphopoietin production in human keratinocytes.

Journal: Journal of dermatological science 20130901

Title: Mechanisms of chemokine responses by polycyclic aromatic hydrocarbons in bronchial epithelial cells: sensitization through toll-like receptor-3 priming.

Journal: Toxicology letters 20130523

Title: Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients.

Journal: Toxicology letters 20130227

Title: A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

Journal: PloS one 20130101

Title: Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model.

Journal: PloS one 20130101

Title: Diesel exhaust particles modify natural killer cell function and cytokine release.

Journal: Particle and fibre toxicology 20130101

Title: Immune modulatory effects of the foodborne contaminant citrinin in mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121001

Title: miR-155 mediates suppressive effect of progesterone on TLR3, TLR4-triggered immune response.

Journal: Immunology letters 20120830

Title: Investigation of the role of TNF-α converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-α production by acute ethanol exposure.

Journal: PloS one 20120101

Title: Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol.

Journal: PloS one 20120101

Title: Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells.

Journal: Cell biology international 20110801

Title: Activation of the maternal immune system induces endocrine changes in the placenta via IL-6.

Journal: Brain, behavior, and immunity 20110501

Title: Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells.

Journal: Toxicology and applied pharmacology 20110101

Title: TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis.

Journal: Cancer science 20100701

Title: Apoptosis induced in chicken embryo fibroblasts in vitro by a polyinosinic:polycytidylic acid copolymer.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001

Title: The role of stress mediators in modulation of cytokine production by ethanol.

Journal: Toxicology and applied pharmacology 20090815

Title: Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin.

Journal: Biochemical pharmacology 20090415

Title: p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines.

Journal: Molecular and cellular biology 20081101

Title: Antiviral responses of human Fallopian tube epithelial cells to toll-like receptor 3 agonist poly(I:C).

Journal: Fertility and sterility 20080501

Title: Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080501

Title: Selenium suppresses the activation of transcription factor NF-kappa B and IRF3 induced by TLR3 or TLR4 agonists.

Journal: International immunopharmacology 20080301

Title: Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101

Title: Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis.

Journal: Gastroenterology 20080101

Title: Effects of 3-phenyl-propenal on the expression of toll-like receptors and downstream signaling components on raw264.7 murine macrophages.

Journal: The American journal of Chinese medicine 20080101

Title: Expression and function of mixed lineage kinases in dendritic cells.

Journal: International immunology 20070801

Title: STAT3 and COX-2 activation in the guinea-pig brain during fever induced by the Toll-like receptor-3 agonist polyinosinic:polycytidylic acid.

Journal: Cell and tissue research 20070601

Title: Concanavalin A induced expression of Toll-like receptors in murine peritoneal macrophages in vitro.

Journal: International immunopharmacology 20070401

Title: The activation of gilthead seabream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish.

Journal: Molecular immunology 20070301

Title: Induction of an anti-inflammatory cytokine, IL-10, in dendritic cells after toll-like receptor signaling.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20061201

Title: Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801

Title: Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation.

Journal: The Journal of allergy and clinical immunology 20060801

Title: Diesel exhaust enhances virus- and poly(I:C)-induced Toll-like receptor 3 expression and signaling in respiratory epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060601

Title: Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners.

Journal: Gastroenterology 20060201

Title: Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050901

Title: Adipocyte fatty acid-binding protein expression and lipid accumulation are increased during activation of murine macrophages by toll-like receptor agonists.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050601

Title: Generation and maturation of dendritic cells for clinical application under serum-free conditions.

Journal: Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101

Title: Maturation of dendritic cells by bacterial immunomodulators.

Journal: Vaccine 20040729

Title: Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists.

Journal: Immunology 20040101

Title: The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin.

Journal: The EMBO journal 20000815

Title: Regulation of cytokine gene expression by adjuvants in vivo.

Journal: Clinical and experimental immunology 19970901

Title: Indomethacin and poly I:C in the inhibition of carcinogen-induced bladder cancer in an experimental animal model.

Journal: The Journal of urology 19840601

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SDS
Tags:24939-03-5 Molecular Formula|24939-03-5 MDL|24939-03-5 SMILES|24939-03-5 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acidhomopolymer (1:1)OTHER CA INDEX NAMES:5'-Cytidylic acid, homopolymer, complex with 5'-inosinic acidhomopolymer (1:1)