Home Imidazoles 25433-13-0
25433-13-0,MFCD01429053
Catalog No.:AA006US7

25433-13-0 | 1-Methyl-5-phenyl-1h-imidazole-2-thiol

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250mg
95%
in stock  
$228.00   $160.00
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1g
95%
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$510.00   $357.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006US7
Chemical Name:
1-Methyl-5-phenyl-1h-imidazole-2-thiol
CAS Number:
25433-13-0
Molecular Formula:
C10H10N2S
Molecular Weight:
190.2648
MDL Number:
MFCD01429053
SMILES:
Cn1c(S)ncc1c1ccccc1
Properties
Properties
 
Storage:
Room Temperature;  

Computed Properties
 
Complexity:
241  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1.6  

Downstream Synthesis Route

[1]Potts,KevinT.;Ehlinger,Robert;Kanemasa,Shuji[JournalofOrganicChemistry,1980,vol.45,#12,p.2474-2479]

13518-55-3    25433-13-0   
2-2-(1H-Imidazol-4-yl)-ethylsulfanyl-1-methyl-5-phenyl-1H-imidazole 

[1]Zuliani,Valentina;Bordi,Fabrizio;Rivara,Mirko;Silva,Claudia;Vacondio,Federica;Morini,Giovanni;Rivara,Silvia;Barocelli,Elisabetta;Ballabeni,Vigilio;Bertoni,Simona;Magnanini,Francesca;Plazzi,PierVincenzo[IlFarmaco,2003,vol.58,#9,p.891-899]

84157-77-7    25433-13-0   
2-3-(1H-Imidazol-4-yl)-propylsulfanyl-1-methyl-5-phenyl-1H-imidazole 

[1]Zuliani,Valentina;Bordi,Fabrizio;Rivara,Mirko;Silva,Claudia;Vacondio,Federica;Morini,Giovanni;Rivara,Silvia;Barocelli,Elisabetta;Ballabeni,Vigilio;Bertoni,Simona;Magnanini,Francesca;Plazzi,PierVincenzo[IlFarmaco,2003,vol.58,#9,p.891-899]

2-methylaminophenylacetaldehydediethylacetal 
  25433-13-0 

[1]CurrentPatentAssignee:SENTRONMEDICALINC;KYOCERACORPORATION;GOVERNMENTOFTHEUNITEDSTATES-US6365616,2002,B1

Literature

Title: Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.

Journal: Molecules (Basel, Switzerland) 20121022

Title: Phenylmethimazole inhibits production of proinflammatory mediators and is protective in an experimental model of endotoxic shock*.

Journal: Critical care medicine 20120301

Title: Another potential therapeutic agent for the management of critically ill patients with sepsis syndrome: same old story, same old result?*.

Journal: Critical care medicine 20120301

Title: Phenylmethimazole blocks palmitate-mediated induction of inflammatory cytokine pathways in 3T3L1 adipocytes and RAW 264.7 macrophages.

Journal: The Journal of endocrinology 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis.

Journal: European journal of pharmacology 20100915

Title: Regulation of major histocompatibility complex gene expression in thyroid epithelial cells by methimazole and phenylmethimazole.

Journal: The Journal of endocrinology 20100101

Title: Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090615

Title: Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis.

Journal: Molecular endocrinology (Baltimore, Md.) 20050501

Title: Phenyl methimazole inhibits TNF-alpha-induced VCAM-1 expression in an IFN regulatory factor-1-dependent manner and reduces monocytic cell adhesion to endothelial cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040801

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SDS
Tags:25433-13-0 Molecular Formula|25433-13-0 MDL|25433-13-0 SMILES|25433-13-0 1-Methyl-5-phenyl-1h-imidazole-2-thiol