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25459-91-0,MFCD22417296
Catalog No.:AA00C4EC

25459-91-0 | DeMethyleneberberine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
95%
1 week  
$174.00   $122.00
- +
5mg
95%
1 week  
$209.00   $147.00
- +
10mg
95%
1 week  
$317.00   $222.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C4EC
Chemical Name:
DeMethyleneberberine
CAS Number:
25459-91-0
Molecular Formula:
C19H18NO4+
Molecular Weight:
324.3505
MDL Number:
MFCD22417296
SMILES:
COc1c(OC)ccc2c1c[n+]1CCc3c(c1c2)cc(c(c3)O)O
Properties

Downstream Synthesis Route
2086-83-1   
1,2,3,4-tetrahydro-6,7-dihydroxy-3-methylene-(2-carboxy-3,4-dihydroxy-benzene)-isoquinoline 
  25459-91-0 

[1]Patent:US2005/13788,2005,A1.Locationinpatent:Page/Pagecolumn10

[1]CurrentPatentAssignee:DIGNITYHEALTH-WO2021/162750,2021,A1Locationinpatent:Paragraph0145-0146

[2]CurrentPatentAssignee:XINTRIAPHARMACEUTICAL;XINTRIAPHARMACEUTICALIN-WO2010/104595,2010,A1Locationinpatent:Page/Pagecolumn103

[1]DrugMetabolismandDisposition,2015,vol.43,p.1100-1107

[1]CurrentPatentAssignee:QINGDAOUNIVERSITYOFSCIENCEANDTECHNOLOGY-CN114848818,2022,ALocationinpatent:Paragraph0045-0046

Literature

Title: Zhang P, et al. Demethyleneberberine, a natural mitochondria-targeted antioxidant, inhibits mitochondrial dysfunction, oxidative stress, and steatosis in alcoholic liver disease mouse model. J Pharmacol Exp Ther. 2015 Jan;352(1):139-47.

Title: Chen YY, et al. Demethyleneberberine alleviates inflammatory bowel disease in mice through regulating NF-κB signaling and T-helper cell homeostasis. Inflamm Res. 2017 Feb;66(2):187-196.

Title: Qiang X, et al. Demethyleneberberine attenuates non-alcoholic fatty liver disease with activation of AMPK and inhibition of oxidative stress. Biochem Biophys Res Commun. 2016 Apr 15;472(4):603-9.

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