Title: Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds.
Journal: Journal of medicinal chemistry 20120628
Title: Orally active glutamate carboxypeptidase II inhibitor 2-MPPA attenuates dizocilpine-induced prepulse inhibition deficits in mice.
Journal: Brain research 20110131
Title: The discovery and structure-activity relationships of indole-based inhibitors of glutamate carboxypeptidase II.
Journal: Bioorganic & medicinal chemistry letters 20101215
Title: Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.
Journal: European journal of pharmacology 20100210
Title: Progress in the discovery and development of glutamate carboxypeptidase II inhibitors.
Journal: Drug discovery today 20070901
Title: The preventive and therapeutic effects of GCPII (NAALADase) inhibition on painful and sensory diabetic neuropathy.
Journal: Journal of the neurological sciences 20060925
Title: Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1' side chain.
Journal: Journal of medicinal chemistry 20060518
Title: 2-MPPA, a selective glutamate carboxypeptidase II inhibitor, attenuates morphine tolerance but not dependence in C57/Bl mice.
Journal: Psychopharmacology 20051201
Title: The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.
Journal: British journal of clinical pharmacology 20050801
Title: Enantiospecificity of glutamate carboxypeptidase II inhibition.
Journal: Journal of medicinal chemistry 20050407
Title: GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic neurotransmission by a presynaptic mechanism.
Journal: Journal of neurophysiology 20040101
Title: Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.
Journal: Bioorganic & medicinal chemistry letters 20030707
Title: Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Journal: Journal of medicinal chemistry 20030508
