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254740-64-2,MFCD16628036
Catalog No.:AA00C2MA

254740-64-2 | Sparsentan (RE-021)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$140.00   $98.00
- +
25mg
98%
in stock  
$231.00   $162.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C2MA
Chemical Name:
Sparsentan (RE-021)
CAS Number:
254740-64-2
Molecular Formula:
C32H40N4O5S
Molecular Weight:
592.7488
MDL Number:
MFCD16628036
SMILES:
CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2
Properties
Computed Properties
 
Complexity:
1060  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
42  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
12  
XLogP3:
5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:LIGANDPHARMACEUTICALSINC-EP2732818,2017,B1Locationinpatent:Paragraph0175;0155;0157

[2]Murugesan,Natesan;Gu,Zhengxiang;Fadnis,Leena;Tellew,JohnE.;Baska,RoseAnnF.;Yang,Yifan;Beyer,SophieM.;Monshizadegan,Hossain;Dickinson,KennethE.;Valentine,MariaT.;Humphreys,W.Griffith;Lan,Shih-Jung;Ewing,WilliamR.;Carlson,KennethE.;Kowala,MarkC.;Zahler,Robert;Macor,JohnE.[JournalofMedicinalChemistry,2005,vol.48,#1,p.171-179]

[3]CurrentPatentAssignee:LIGANDPHARMACEUTICALSINC-WO2010/135350,2010,A2Locationinpatent:Page/Pagecolumn22-23

[1]Murugesan,Natesan;Gu,Zhengxiang;Fadnis,Leena;Tellew,JohnE.;Baska,RoseAnnF.;Yang,Yifan;Beyer,SophieM.;Monshizadegan,Hossain;Dickinson,KennethE.;Valentine,MariaT.;Humphreys,W.Griffith;Lan,Shih-Jung;Ewing,WilliamR.;Carlson,KennethE.;Kowala,MarkC.;Zahler,Robert;Macor,JohnE.[JournalofMedicinalChemistry,2005,vol.48,#1,p.171-179]

190197-86-5   
4'-(2-butyl-4-oxo-1,3-diazaspiro4.4non-1-en-3-yl)methyl-N-(4,5-dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)1,1'-biphenyl-2-sulfonamide 

[1]Murugesan,Natesan;Gu,Zhengxiang;Fadnis,Leena;Tellew,JohnE.;Baska,RoseAnnF.;Yang,Yifan;Beyer,SophieM.;Monshizadegan,Hossain;Dickinson,KennethE.;Valentine,MariaT.;Humphreys,W.Griffith;Lan,Shih-Jung;Ewing,WilliamR.;Carlson,KennethE.;Kowala,MarkC.;Zahler,Robert;Macor,JohnE.[JournalofMedicinalChemistry,2005,vol.48,#1,p.171-179]

[1]Murugesan,Natesan;Gu,Zhengxiang;Fadnis,Leena;Tellew,JohnE.;Baska,RoseAnnF.;Yang,Yifan;Beyer,SophieM.;Monshizadegan,Hossain;Dickinson,KennethE.;Valentine,MariaT.;Humphreys,W.Griffith;Lan,Shih-Jung;Ewing,WilliamR.;Carlson,KennethE.;Kowala,MarkC.;Zahler,Robert;Macor,JohnE.[JournalofMedicinalChemistry,2005,vol.48,#1,p.171-179]

[2]CurrentPatentAssignee:LIGANDPHARMACEUTICALSINC-EP2732818,2017,B1

[1]Murugesan,Natesan;Gu,Zhengxiang;Fadnis,Leena;Tellew,JohnE.;Baska,RoseAnnF.;Yang,Yifan;Beyer,SophieM.;Monshizadegan,Hossain;Dickinson,KennethE.;Valentine,MariaT.;Humphreys,W.Griffith;Lan,Shih-Jung;Ewing,WilliamR.;Carlson,KennethE.;Kowala,MarkC.;Zahler,Robert;Macor,JohnE.[JournalofMedicinalChemistry,2005,vol.48,#1,p.171-179]

[2]CurrentPatentAssignee:LIGANDPHARMACEUTICALSINC-EP2732818,2017,B1

Literature

Title: Chemokine receptor antagonists.

Journal: Journal of medicinal chemistry 20121126

Title: Focal segmental glomerulosclerosis.

Journal: The New England journal of medicine 20111222

Title: Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics.

Journal: Journal of medicinal chemistry 20050113

Title: Murugesan N, et al. Dual angiotensin II and endothelin A receptor antagonists: synthesis of 2'-substituted N-3-isoxazolyl biphenylsulfonamides with improved potency and pharmacokinetics. J Med Chem. 2005 Jan 13;48(1):171-9.

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