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256-96-2,MFCD00005071
Catalog No.:AA003MPB

256-96-2 | Iminostilbene

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5g
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$9.00   $7.00
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25g
97%
in stock  
$19.00   $14.00
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100g
97%
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$63.00   $44.00
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500g
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003MPB
Chemical Name:
Iminostilbene
CAS Number:
256-96-2
Molecular Formula:
C14H11N
Molecular Weight:
193.2438
MDL Number:
MFCD00005071
SMILES:
c1ccc2c(c1)C=Cc1c(N2)cccc1
NSC Number:
123458
Properties
Properties
 
BP:
221°C at 760 mmHg  
Form:
Solid  
MP:
197 °C  
Refractive Index:
n20/D 1.523(lit.)  
Solubility:
dioxane: 50 mg/mL, clear  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
222  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
4  

Literature

Title: Formation mechanism of a new carbamazepine/malonic acid cocrystal polymorph.

Journal: International journal of pharmaceutics 20120715

Title: Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD.

Journal: Journal of Crohn's & colitis 20120501

Title: First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.

Journal: The Journal of biological chemistry 20120406

Title: 5-(Prop-2-yn-yl)-5H-dibenzo[b,f]azepine.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: A multiparametric approach to monitor the effects of γ-secretase inhibition along the whole intestinal tract.

Journal: Disease models & mechanisms 20120101

Title: Relationship of cardiovascular complications with level of consciousness in patients with acute carbamazepine intoxication.

Journal: Medicinski arhiv 20120101

Title: Carbamazepine-induced hepato-splenomegaly with erythematous rashes in a child.

Journal: Indian journal of pharmacology 20120101

Title: Development and validation of quantitative structure-activity relationship models for compounds acting on serotoninergic receptors.

Journal: TheScientificWorldJournal 20120101

Title: Delta-like ligand 4-notch blockade and tumor radiation response.

Journal: Journal of the National Cancer Institute 20111207

Title: [New antiepileptic drugs, and therapeutic considerations].

Journal: Ideggyogyaszati szemle 20110930

Title: A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

Journal: Nature chemical biology 20110925

Title: DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Journal: Cancer research 20110915

Title: Notch signaling modulates MUC16 biosynthesis in an in vitro model of human corneal and conjunctival epithelial cell differentiation.

Journal: Investigative ophthalmology & visual science 20110701

Title: Opipramol.

Journal: Acta crystallographica. Section E, Structure reports online 20110701

Title: An efficient approach to azirino and pyrrolo-fused dibenzazepines. Conformations of substituted dibenzo[c,f]pyrrolo[1,2-a]azepines.

Journal: Organic & biomolecular chemistry 20110521

Title: Effects of combination of notch inhibitor plus hedgehog inhibitor or Wnt inhibitor on growth of leukemia cells.

Journal: Anticancer research 20110301

Title: Presence and ex vivo formation of acridone in blood of patients routinely treated with carbamazepine: exploration of the 9-acridinecarboxaldehyde pathway.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110201

Title: Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.

Journal: Pharmacological reports : PR 20110101

Title: Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice.

Journal: PloS one 20110101

Title: Synthesis and antiulcer activity evaluation of conjugates of amino acids with N-aroyl- N, N'-dicyclohexyl urea.

Journal: Chemistry Central journal 20110101

Title: Therapeutic targeting of cancer stem cells.

Journal: Frontiers in oncology 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice.

Journal: Journal of gastroenterology 20100601

Title: Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors.

Journal: Nature communications 20100517

Title: Preparation and physicochemical characterization of a novel water-soluble prodrug of carbamazepine.

Journal: Journal of pharmaceutical sciences 20100401

Title: Trimipraminium maleate.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Synthesis and antioxidant properties of some novel 5H-dibenz[b,f]azepine derivatives in different in vitro model systems.

Journal: European journal of medicinal chemistry 20100101

Title: Conversion of metaplastic Barrett's epithelium into post-mitotic goblet cells by gamma-secretase inhibition.

Journal: Disease models & mechanisms 20100101

Title: Role of eslicarbazepine in the treatment of epilepsy in adult patients with partial-onset seizures.

Journal: Therapeutics and clinical risk management 20100101

Title: Determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in solid dosage form by column high-performance liquid chromatography.

Journal: Journal of AOAC International 20100101

Title: Gene expression profile analysis of genes in rat hippocampus from antidepressant treated rats using DNA microarray.

Journal: BMC neuroscience 20100101

Title: Studies of Antimicrobial Activities of some 4-Thiazolidinone Fused Pyrimidines, [1,5]-Benzodiazepines and their Oxygen Substituted Hydroxylamine Derivatives.

Journal: Indian journal of pharmaceutical sciences 20100101

Title: Rational design and synthesis of potent dibenzazepine motifs as beta-secretase inhibitors.

Journal: Journal of medicinal chemistry 20091022

Title: Fate of carbamazepine during water treatment.

Journal: Environmental science & technology 20090815

Title: Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.

Journal: Journal of neurochemistry 20090701

Title: Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening.

Journal: PLoS neglected tropical diseases 20090701

Title: Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

Journal: Nature medicine 20090601

Title: Presence and fate of carbamazepine, oxcarbazepine, and seven of their metabolites at wastewater treatment plants.

Journal: Archives of environmental contamination and toxicology 20090401

Title: Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.

Journal: Molecular cancer research : MCR 20081201

Title: Thermal ring contraction of dibenz[b,f]azepin-5-yl radicals: new routes to pyrrolo[3,2,1-jk]carbazoles.

Journal: The Journal of organic chemistry 20080905

Title: Cytenamide-formic acid (1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: Cytenamide trifluoro-acetic acid solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080701

Title: Cytenamide-butyric acid (1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20080701

Title: Cytenamide-1,4-dioxane (2/1).

Journal: Acta crystallographica. Section E, Structure reports online 20080701

Title: Cytenamide acetic acid solvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: The Notch pathway in podocytes plays a role in the development of glomerular disease.

Journal: Nature medicine 20080301

Title: Notch signaling is required for exocrine regeneration after acute pancreatitis.

Journal: Gastroenterology 20080201

Title: Spectrophotometric determination of etodolac in pure form and pharmaceutical formulations.

Journal: Chemistry Central journal 20080101

Title: [Immunochemical properties of conjugated antigens from N-substituted phenothiazines and dibenzazepines with antiarrhythmic activity].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20080101

Title: Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells.

Journal: Cell communication and signaling : CCS 20080101

Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.

Journal: Perspectives in medicinal chemistry 20080101

Title: Design, synthesis and biological evaluation of new oligopyrrole carboxamides linked with tricyclic DNA-intercalators as potential DNA ligands or topoisomerase inhibitors.

Journal: European journal of medicinal chemistry 20070601

Title: Free-radical-scavenging effect of carbazole derivatives on AAPH-induced hemolysis of human erythrocytes.

Journal: Bioorganic & medicinal chemistry 20070301

Title: Trypanothione reductase: a viable chemotherapeutic target for antitrypanosomal and antileishmanial drug design.

Journal: Drug target insights 20070101

Title: The role of serendipity in drug discovery.

Journal: Dialogues in clinical neuroscience 20060901

Title: Activation of T cells by carbamazepine and carbamazepine metabolites.

Journal: The Journal of allergy and clinical immunology 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Liquid chromatography-electrospray mass spectrometry determination of carbamazepine, oxcarbazepine and eight of their metabolites in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051215

Title: Intravenous immunoglobulin for treatment of toxic epidermal necrolysis.

Journal: The American journal of the medical sciences 20050201

Title: 2,2'-Bipyridine as a new and sensitive spectrophotometric reagent for the determination of nanoamounts of certain dibenzazepine class of tricyclic antidepressant drugs.

Journal: Farmaco (Societa chimica italiana : 1989) 20050101

Title: Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093.

Journal: Epilepsia 20041201

Title: Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041101

Title: Synthesis of medium ring heterocycles using an intramolecular Heck reaction.

Journal: Organic letters 20040819

Title: Homoheteroaromaticity: the case study of azepine and dibenzazepine.

Journal: Organic & biomolecular chemistry 20040607

Title: Substituent-dependent reactivity in the photodimerization of N-substituted dibenz[b,f]azepines.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040105

Title: Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain.

Journal: Acta biochimica Polonica 20040101

Title: Functionally distinct dopamine and octopamine transporters in the CNS of the cabbage looper moth.

Journal: European journal of biochemistry 20030201

Title: Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum.

Journal: Journal of medicinal chemistry 20020620

Title: Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay.

Journal: Mutation research 20020619

Title: Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.

Journal: Acta crystallographica. Section D, Biological crystallography 20020601

Title: [Tricyclic antidepressants as inhibitors of brain glutathione-S-transferase].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20011201

Title: Protective activity of aromatic amines and imines against oxidative nerve cell death.

Journal: Biological chemistry 20011101

Title: Hexamethonium-type allosteric modulators of the muscarinic receptors bearing lateral dibenzazepine moieties.

Journal: Archiv der Pharmazie 20010401

Title: Interactions between carbamazepine and polyethylene glycol (PEG) 6000: characterisations of the physical, solid dispersed and eutectic mixtures.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201

Title: Christian P, et al. Crystallization of Carbamazepine in Proximity to Its Precursor Iminostilbene and a Silica Surface. Cryst Growth Des. 2016 May 4;16(5):2771-2778. Epub 2016 Mar 30.

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Tags:256-96-2 Molecular Formula|256-96-2 MDL|256-96-2 SMILES|256-96-2 Iminostilbene