Title: Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade.
Journal: Chemico-biological interactions 20140725
Title: Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.
Journal: British journal of pharmacology 20121001
Title: Vas deferens smooth muscle responses to the nitric oxide-independent soluble guanylate cyclase stimulator BAY 41-2272.
Journal: European journal of pharmacology 20120805
Title: Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate cyclase stimulator BAY 41-2272 in mouse gastric fundus and colon.
Journal: European journal of pharmacology 20120705
Title: BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes.
Journal: British journal of pharmacology 20120701
Title: Curcumin induces differentiation of embryonic stem cells through possible modulation of nitric oxide-cyclic GMP pathway.
Journal: Protein & cell 20120701
Title: Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis.
Journal: Annals of the rheumatic diseases 20120601
Title: Immunohistochemical and functional characterization of nitric oxide signaling pathway in isolated aorta from Crotalus durissus terrificus.
Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120401
Title: Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.
Journal: The Journal of pharmacology and experimental therapeutics 20120301
Title: Platelet hyperaggregability in high-fat fed rats: a role for intraplatelet reactive-oxygen species production.
Journal: Cardiovascular diabetology 20120101
Title: Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats.
Journal: Proteomics 20111201
Title: Thioredoxin reductase inhibition reduces relaxation by increasing oxidative stress and s-nitrosylation in mouse aorta.
Journal: Journal of cardiovascular pharmacology 20111101
Title: The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways.
Journal: The Journal of pharmacology and experimental therapeutics 20111101
Title: Long-term oral treatment with BAY 41-2272 ameliorates impaired corpus cavernosum relaxations in a nitric oxide-deficient rat model.
Journal: BJU international 20110701
Title: Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus.
Journal: The journal of sexual medicine 20110601
Title: NO-induced activation of cyclic GMP-dependent pathway down regulates ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) protein in rat C6 glioma.
Journal: European journal of pharmacology 20110520
Title: Long-term administration of BAY 41-2272 prevents bladder dysfunction in nitric oxide-deficient rats.
Journal: Neurourology and urodynamics 20110301
Title: The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine.
Journal: Canadian journal of physiology and pharmacology 20110201
Title: BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats.
Journal: European journal of pharmacology 20101125
Title: The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide.
Journal: British journal of pharmacology 20101101
Title: Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.
Journal: European journal of pharmacology 20101025
Title: Heme oxygenase-1 deficiency leads to alteration of soluble guanylate cyclase redox regulation.
Journal: The Journal of pharmacology and experimental therapeutics 20101001
Title: Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
Journal: Pancreas 20100801
Title: Evaluation of the relaxant effect of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in isolated detrusor smooth muscle.
Journal: European journal of pharmacology 20100710
Title: Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation.
Journal: Biochemical and biophysical research communications 20100702
Title: Nitric oxide stimulates interleukin-6 production in skeletal myotubes.
Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20100501
Title: Effects of sex and estrogen on chicken ductus arteriosus reactivity.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100501
Title: Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation.
Journal: Nitric oxide : biology and chemistry 20100101
Title: Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner.
Journal: PloS one 20100101
Title: Soluble guanylate cyclase agonists inhibit expression and procoagulant activity of tissue factor.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001
Title: Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart.
Journal: American journal of physiology. Heart and circulatory physiology 20091001
Title: Light-induced vs. bradykinin-induced relaxation of coronary arteries: do S-nitrosothiols act as endothelium-derived hyperpolarizing factors?
Journal: Journal of hypertension 20090801
Title: Nitrite or sildenafil, but not BAY 41-2272, blunt acute pulmonary embolism-induced increases in circulating matrix metalloproteinase-9 and oxidative stress.
Journal: Thrombosis research 20090701
Title: Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20090701
Title: Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
Journal: British journal of pharmacology 20090701
Title: Soluble guanylate cyclase: not a dull enzyme.
Journal: Circulation 20090602
Title: Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats.
Journal: American journal of hypertension 20090501
Title: Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.
Journal: ChemMedChem 20090501
Title: NO-independent activators of soluble guanylate cyclase: therapeutic potential.
Journal: American journal of hypertension 20090501
Title: Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury.
Journal: American journal of physiology. Lung cellular and molecular physiology 20090301
Title: Antigrowth properties of BAY 41-2272 in vascular smooth muscle cells.
Journal: Journal of cardiovascular pharmacology 20090201
Title: YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells.
Journal: Molecular pharmacology 20090101
Title: Activation of BKCa channels by nitric oxide prevents coronary artery endothelial dysfunction in ouabain-induced hypertensive rats.
Journal: Journal of hypertension 20090101
Title: Binding of YC-1 or BAY 41-2272 to soluble guanylyl cyclase induces a geminate phase in CO photolysis.
Journal: Journal of the American Chemical Society 20081126
Title: Increased cyclic guanosine monophosphate synthesis and calcium entry blockade account for the relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in the rabbit penile urethra.
Journal: Urology 20080901
Title: An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase.
Journal: The Journal of biological chemistry 20080704
Title: Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.
Journal: Cardiovascular research 20080701
Title: Endothelium removal augments endothelium-independent vasodilatation in rat mesenteric vascular bed.
Journal: British journal of pharmacology 20080501
Title: Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation.
Journal: Haematologica 20080401
Title: Dose-dependent beneficial hemodynamic effects of BAY 41-2272 in a canine model of acute pulmonary thromboembolism.
Journal: European journal of pharmacology 20080226
Title: Novel therapies for cyclic GMP control of vascular smooth muscle growth.
Journal: American journal of therapeutics 20080101
Title: Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.
Journal: American journal of respiratory and critical care medicine 20071201
Title: Gastric motility in soluble guanylate cyclase alpha 1 knock-out mice.
Journal: The Journal of physiology 20071101
Title: Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Journal: Cardiovascular research 20071001
Title: Effects of 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine (BAY 41-2272) on smooth muscle tone, soluble guanylyl cyclase activity, and NADPH oxidase activity/expression in corpus cavernosum from wild-type, neuronal, and endothelial nitric-oxide synthase null mice.
Journal: The Journal of pharmacology and experimental therapeutics 20070901
Title: Effects of BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase, on human NADPH oxidase system from THP-1 cells.
Journal: European journal of pharmacology 20070712
Title: A cell-based nitric oxide reporter assay useful for the identification and characterization of modulators of the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway.
Journal: Analytical biochemistry 20070415
Title: Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii.
Journal: Experimental physiology 20070301
Title: Protective effect of prior physical conditioning on relaxing response of corpus cavernosum from rats made hypertensive by nitric oxide inhibition.
Journal: International journal of impotence research 20070101
Title: Elevated pressure selectively blunts flow-evoked vasodilatation in rat mesenteric small arteries.
Journal: British journal of pharmacology 20070101
Title: Effect of BAY 41-2272 in the pulmonary hypertension induced by heparin-protamine complex in anaesthetized dogs.
Journal: Clinical and experimental pharmacology & physiology 20070101
Title: Nitric oxide-independent stimulation of soluble guanylate cyclase with BAY 41-2272 in cardiovascular disease.
Journal: Cardiovascular drug reviews 20070101
Title: Soluble guanylyl cyclase activation promotes angiogenesis.
Journal: The Journal of pharmacology and experimental therapeutics 20061101
Title: Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20061101
Title: Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress.
Journal: Free radical biology & medicine 20060815
Title: Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl Indazole].
Journal: The Journal of pharmacology and experimental therapeutics 20060401
Title: Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms.
Journal: Hypertension (Dallas, Tex. : 1979) 20060301
Title: Protective effects of BAY 41-2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAME treatment in rats.
Journal: Journal of cardiovascular pharmacology 20060301
Title: Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling.
Journal: Circulation 20060117
Title: Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Journal: European journal of pharmacology 20060113
Title: Enhancing cGMP in experimental progressive renal fibrosis: soluble guanylate cyclase stimulation vs. phosphodiesterase inhibition.
Journal: American journal of physiology. Renal physiology 20060101
Title: BAY 41-2272, a direct activator of soluble guanylate cyclase, reduces right ventricular hypertrophy and prevents pulmonary vascular remodeling during chronic hypoxia in neonatal rats.
Journal: Biology of the neonate 20060101
Title: Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line.
Journal: Molecular pharmacology 20051201
Title: BAY 41-2272, a potent activator of soluble guanylyl cyclase, stimulates calcium elevation and calcium-activated potassium current in pituitary GH cells.
Journal: Clinical and experimental pharmacology & physiology 20051201
Title: Pulmonary vascular effects of nitric oxide-cGMP augmentation in a model of chronic pulmonary hypertension in fetal and neonatal sheep.
Journal: American journal of physiology. Lung cellular and molecular physiology 20051101
Title: Mechanisms underlying relaxation of rabbit aorta by BAY 41-2272, a nitric oxide-independent soluble guanylate cyclase activator.
Journal: Clinical and experimental pharmacology & physiology 20050901
Title: Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050720
Title: BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump.
Journal: The Journal of pharmacology and experimental therapeutics 20050701
Title: Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis.
Journal: Kidney international 20050701
Title: Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Journal: European journal of pharmacology 20050418
Title: Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.
Journal: Journal of the American Chemical Society 20050406
Title: Stimulation of soluble guanylyl cyclase inhibits mesangial cell proliferation and matrix accumulation in experimental glomerulonephritis.
Journal: American journal of physiology. Renal physiology 20050401
Title: Effects of BAY 41-2272, a soluble guanylate cyclase activator, on pulmonary vascular reactivity in the ovine fetus.
Journal: American journal of physiology. Lung cellular and molecular physiology 20050401
Title: Inhibitory effects on human eosinophil chemotaxis in vitro by BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase.
Journal: Biochemical pharmacology 20050315
Title: A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats.
Journal: International journal of impotence research 20041201
Title: Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritis.
Journal: Kidney international 20041201
Title: Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs.
Journal: Circulation 20041012
Title: Effects of the sGC stimulator BAY 41-2272 are not mediated by phosphodiesterase 5 inhibition.
Journal: Circulation 20040921
Title: High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria.
Journal: Circulation research 20040416
Title: Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.
Journal: Circulation 20040413
Title: Functional characterization of nitric oxide and YC-1 activation of soluble guanylyl cyclase: structural implication for the YC-1 binding site?
Journal: Biochemistry 20040323
Title: Synthesis of nitric oxide in postganglionic myenteric neurons during endotoxemia: implications for gastric motor function in rats.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040301
Title: Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272.
Journal: Vascular pharmacology 20031001
Title: Relaxing effects induced by the soluble guanylyl cyclase stimulator BAY 41-2272 in human and rabbit corpus cavernosum.
Journal: European journal of pharmacology 20030912
Title: Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.
Journal: The Journal of biological chemistry 20030718
Title: Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure.
Journal: Circulation 20030211
Title: BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.
Journal: The Journal of urology 20030201
Title: BAY 41-2272: a stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo.
Journal: Urology 20030201
Title: The Rho-kinase inhibitor Y-27632 and the soluble guanylyl cyclase activator BAY41-2272 relax rabbit vaginal wall and clitoral corpus cavernosum.
Journal: British journal of pharmacology 20030101
Title: Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.
Journal: Bioorganic & medicinal chemistry 20020601
Title: BAY 41-2272 activates two isoforms of nitric oxide-sensitive guanylyl cyclase.
Journal: Biochemical and biophysical research communications 20020412
Title: Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies.
Journal: British journal of pharmacology 20020101
Title: NO-independent stimulators of soluble guanylate cyclase.
Journal: Bioorganic & medicinal chemistry letters 20010326
Title: NO-independent regulatory site on soluble guanylate cyclase.
Journal: Nature 20010308
Title: NO-independent regulatory site of direct sGC stimulators like YC-1 and BAY 41-2272.
Journal: BMC pharmacology 20010101
Title: Spin-labelled phosphofructokinase. A simple and direct approach to the study of allosteric equilibria under near-physiological conditions.
Journal: European journal of biochemistry 19751201
Title: Tuttle TR, et al. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer Lett. 2016 Jan 28;370(2):279-85.
Title: Boerrigter G, et al. Cardiorenal and humoral properties of a novel direct soluble guanylate cyclase stimulator BAY 41-2272 in experimental congestive heart failure. Circulation. 2003 Feb 11;107(5):686-9.
