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256382-08-8
Catalog No.:AA00BJUS

256382-08-8 | rivenprost

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1mg
≥98%
in stock  
$399.00   $279.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BJUS
Chemical Name:
rivenprost
CAS Number:
256382-08-8
Molecular Formula:
C24H34O6S
Molecular Weight:
450.5882
SMILES:
COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O
Properties
Computed Properties
 
Complexity:
580  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
14  
XLogP3:
1.8  

Literature

Title: Emerging targets in osteoporosis disease modification.

Journal: Journal of medicinal chemistry 20100610

Title: Effect of EP4 agonist (ONO-4819CD) for patients with mild to moderate ulcerative colitis refractory to 5-aminosalicylates: a randomized phase II, placebo-controlled trial.

Journal: Inflammatory bowel diseases 20100501

Title: An improved synthesis of the selective EP4 receptor agonist ONO-4819.

Journal: The Journal of organic chemistry 20091106

Title: Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation.

Journal: Bone 20071001

Title: Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism.

Journal: Cancer research 20061001

Title: Effects of a prostaglandin EP4 agonist, ONO-4819, and risedronate on trabecular microstructure and bone strength in mature ovariectomized rats.

Journal: Bone 20060901

Title: Prostaglandin E2 EP4 receptor-selective agonist facilitates sternal healing after harvesting bilateral internal thoracic arteries in diabetic rats.

Journal: The Journal of thoracic and cardiovascular surgery 20060301

Title: Prostaglandin D2 and prostaglandin E2 accelerate the recovery of cutaneous barrier disruption induced by mechanical scratching in mice.

Journal: European journal of pharmacology 20050725

Title: Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP4 receptor agonist, in MOLT-3 human leukemic T cells.

Journal: Vascular pharmacology 20040301

Title: Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20020402

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