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256951-79-8,MFCD09788613
Catalog No.:AA00BJ7Q

256951-79-8 | tert-Butyl 4-cyano-4-(4-fluorophenyl)piperidine-1-carboxylate

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25mg
≥ 90% (HPLC)
in stock  
$221.00   $155.00
- +
100mg
≥ 90% (HPLC)
in stock  
$419.00   $294.00
- +
250mg
≥ 90% (HPLC)
in stock  
$749.00   $524.00
- +
1g
≥ 90% (HPLC)
in stock  
$1,525.00   $1,068.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00BJ7Q
Chemical Name:
tert-Butyl 4-cyano-4-(4-fluorophenyl)piperidine-1-carboxylate
CAS Number:
256951-79-8
Molecular Formula:
C17H21FN2O2
Molecular Weight:
304.3592
MDL Number:
MFCD09788613
SMILES:
N#CC1(CCN(CC1)C(=O)OC(C)(C)C)c1ccc(cc1)F
Properties
Computed Properties
 
Complexity:
447  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
2.9  

Downstream Synthesis Route

[1]CurrentPatentAssignee:MERCK&COINC-WO2004/4722,2004,A1Locationinpatent:Page/Pagecolumn20;50-51

[2]CurrentPatentAssignee:VIAMETPHARMACEUTICALSHOLDINGS;EIKONIZOTHERAPEUTICS-WO2018/165520,2018,A1Locationinpatent:Page/Pagecolumn165

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-US2009/18132,2009,A1Locationinpatent:Page/Pagecolumn41

[4]Barrow,JamesC.;Nantermet,PhilippeG.;Selnick,HaroldG.;Glass,KristenL.;Rittle,KennethE.;Gilbert,KevinF.;Steele,ThomasG.;Homnick,CarlF.;Freidinger,RogerM.;Ransom,RickW.;Kling,Paul;Reiss,Duane;Broten,TheodoreP.;Schorn,TerryW.;Chang,RaymondS.L.;O'Malley,StaceyS.;Olah,TimothyV.;Ellis,JoanD.;Barrish,Andrea;Kassahun,Kelem;Leppert,Paula;Nagarathnam,Dhanapalan;Forray,Carlos[JournalofMedicinalChemistry,2000,vol.43,#14,p.2703-2718]

[5]Zhang,Daoguang;Tong,Dongdong;Yang,Dezhi;Sun,Jing;Zhang,Fenghe;Zhao,Guisen[MedChemComm,2018,vol.9,#8,p.1340-1350]

[6]Dhar,T.G.Murali;Nagarathnam,Dhanapalan;Marzabadi,MohammadR.;Lagu,Bharat;Wong,WaiC.;Chiu,George;Tyagarajan,Sriram;Miao,ShouWu;Zhang,Fengqi;Sun,Wanying;Tian,Dake;Shen,Quanrong;Zhang,Jack;Wetzel,JohnM.;Forray,Carlos;Chang,RaymondS.L.;Broten,TheodoreP.;Schorn,TerryW.;Chen,TsingBao;O'Malley,Stacy;Ransom,Richard;Schneck,Kathryn;Bendesky,Robert;Harrell,CharlesM.;Vyas,KamleshP.;Zhang,Kanyin;Gilbert,John;Pettibone,DouglasJ.;Patane,MichaelA.;Bock,MarkG.;Freidinger,RogerM.;Gluchowski,Charles[JournalofMedicinalChemistry,1999,vol.42,#23,p.4778-4793]

[7]Nantermet;Barrow;Selnick;Homnick;Freidinger;Chang;O'Malley;Reiss;Broten;Ransom;Pettibone;Olah;Forray[Bioorganicandmedicinalchemistryletters,2000,vol.10,#15,p.1625-1628]

[8]CurrentPatentAssignee:SANOFI-US2007/142349,2007,A1Locationinpatent:Page/Pagecolumn25

[9]Locationinpatent:experimentalpartKuduk,ScottD.;Chang,RonaldK.;DiMarco,ChristinaN.;Pitts,DanielR.;Greshock,ThomasJ.;Ma,Lei;Wittmann,Marion;Seager,MatthewA.;Koeplinger,KennethA.;Thompson,CharlesD.;Hartman,GeorgeD.;Bilodeau,MarkT.;Ray,WilliamJ.[JournalofMedicinalChemistry,2011,vol.54,#13,p.4773-4780]

[10]CurrentPatentAssignee:MERCK&COINC-WO2015/73310,2015,A1Locationinpatent:Page/Pagecolumn44

[11]CurrentPatentAssignee:MERCK&COINC-WO2015/70367,2015,A1Locationinpatent:Page/Pagecolumn43

[12]CurrentPatentAssignee:MERCK&COINC-US6339090,2002,B1Locationinpatent:Example3

[1]CurrentPatentAssignee:MERCK&COINC-WO2015/70367,2015,A1Locationinpatent:Page/Pagecolumn43;44

[2]Dhar,T.G.Murali;Nagarathnam,Dhanapalan;Marzabadi,MohammadR.;Lagu,Bharat;Wong,WaiC.;Chiu,George;Tyagarajan,Sriram;Miao,ShouWu;Zhang,Fengqi;Sun,Wanying;Tian,Dake;Shen,Quanrong;Zhang,Jack;Wetzel,JohnM.;Forray,Carlos;Chang,RaymondS.L.;Broten,TheodoreP.;Schorn,TerryW.;Chen,TsingBao;O'Malley,Stacy;Ransom,Richard;Schneck,Kathryn;Bendesky,Robert;Harrell,CharlesM.;Vyas,KamleshP.;Zhang,Kanyin;Gilbert,John;Pettibone,DouglasJ.;Patane,MichaelA.;Bock,MarkG.;Freidinger,RogerM.;Gluchowski,Charles[JournalofMedicinalChemistry,1999,vol.42,#23,p.4778-4793]

[3]CurrentPatentAssignee:VIAMETPHARMACEUTICALSHOLDINGS;EIKONIZOTHERAPEUTICS-WO2018/165520,2018,A1Locationinpatent:Page/Pagecolumn165-166

[4]CurrentPatentAssignee:MERCK&COINC-US6339090,2002,B1

256951-79-8   
4-(4-fluorophenyl)-piperidin-4-carbonitrilehydrochloride 

[1]CurrentPatentAssignee:MERCK&COINC-WO2015/73310,2015,A1Locationinpatent:Page/Pagecolumn44;45

[2]Barrow,JamesC.;Nantermet,PhilippeG.;Selnick,HaroldG.;Glass,KristenL.;Rittle,KennethE.;Gilbert,KevinF.;Steele,ThomasG.;Homnick,CarlF.;Freidinger,RogerM.;Ransom,RickW.;Kling,Paul;Reiss,Duane;Broten,TheodoreP.;Schorn,TerryW.;Chang,RaymondS.L.;O'Malley,StaceyS.;Olah,TimothyV.;Ellis,JoanD.;Barrish,Andrea;Kassahun,Kelem;Leppert,Paula;Nagarathnam,Dhanapalan;Forray,Carlos[JournalofMedicinalChemistry,2000,vol.43,#14,p.2703-2718]

[3]Nantermet;Barrow;Selnick;Homnick;Freidinger;Chang;O'Malley;Reiss;Broten;Ransom;Pettibone;Olah;Forray[Bioorganicandmedicinalchemistryletters,2000,vol.10,#15,p.1625-1628]

[4]CurrentPatentAssignee:MERCK&COINC-US6235759,2001,B1

[5]CurrentPatentAssignee:SANOFI-US2007/142349,2007,A1Locationinpatent:Page/Pagecolumn25-26

[6]Locationinpatent:experimentalpartKuduk,ScottD.;Chang,RonaldK.;DiMarco,ChristinaN.;Pitts,DanielR.;Greshock,ThomasJ.;Ma,Lei;Wittmann,Marion;Seager,MatthewA.;Koeplinger,KennethA.;Thompson,CharlesD.;Hartman,GeorgeD.;Bilodeau,MarkT.;Ray,WilliamJ.[JournalofMedicinalChemistry,2011,vol.54,#13,p.4773-4780]

[7]CurrentPatentAssignee:MERCK&COINC-US6339090,2002,B1Locationinpatent:Example3

[1]Liu,Jian;Jian,Tianying;Sebhat,Iyassu;Nargund,Ravi[TetrahedronLetters,2006,vol.47,#29,p.5115-5117]

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2004/56771,2004,A1Locationinpatent:Page23

[2]Liu,Jian;Jian,Tianying;Sebhat,Iyassu;Nargund,Ravi[TetrahedronLetters,2006,vol.47,#29,p.5115-5117]

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Tags:256951-79-8 Molecular Formula|256951-79-8 MDL|256951-79-8 SMILES|256951-79-8 tert-Butyl 4-cyano-4-(4-fluorophenyl)piperidine-1-carboxylate