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257639-98-8,MFCD07364047
Catalog No.:AA00C37U

257639-98-8 | CP 154526

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1mg
≥98%
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$88.00   $61.00
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5mg
≥98%
in stock  
$133.00   $93.00
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10mg
≥98%
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$219.00   $153.00
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50mg
99%
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C37U
Chemical Name:
CP 154526
CAS Number:
257639-98-8
Molecular Formula:
C23H33ClN4
Molecular Weight:
400.9879
MDL Number:
MFCD07364047
SMILES:
CCCCN(c1nc(C)nc2c1c(C)cn2c1c(C)cc(cc1C)C)CC.Cl
Properties
Computed Properties
 
Complexity:
457  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  

Literature

Title: Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes.

Journal: Psychopharmacology 20120201

Title: Effects of acute stress on acquisition of nicotine conditioned place preference in adolescent rats: a role for corticotropin-releasing factor 1 receptors.

Journal: Psychopharmacology 20120101

Title: Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc).

Journal: PloS one 20120101

Title: Prevention of social stress-escalated cocaine self-administration by CRF-R1 antagonist in the rat VTA.

Journal: Psychopharmacology 20111101

Title: α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking.

Journal: Biological psychiatry 20111015

Title: Blocking corticotropin-releasing factor-2 receptors, but not corticotropin-releasing factor-1 receptors or glucocorticoid feedback, disrupts the development of conditioned defeat.

Journal: Physiology & behavior 20101102

Title: Stress-induced priming of glutamate synapses unmasks associative short-term plasticity.

Journal: Nature neuroscience 20101001

Title: Pain is a salient 'stressor' that is mediated by corticotropin-releasing factor-1 receptors.

Journal: Neuropharmacology 20100901

Title: CRF-1 antagonist and CRF-2 agonist decrease binge-like ethanol drinking in C57BL/6J mice independent of the HPA axis.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100501

Title: The alarm pheromone in male rats as a unique anxiety model: psychopharmacological evidence using anxiolytics.

Journal: Pharmacology, biochemistry, and behavior 20100201

Title: Social subordination and polymorphisms in the gene encoding the serotonin transporter enhance estradiol inhibition of luteinizing hormone secretion in female rhesus monkeys.

Journal: Biology of reproduction 20091201

Title: The alcohol deprivation effect in C57BL/6J mice is observed using operant self-administration procedures and is modulated by CRF-1 receptor signaling.

Journal: Alcoholism, clinical and experimental research 20090101

Title: A comparison of ligand based virtual screening methods and application to corticotropin releasing factor 1 receptor.

Journal: Journal of molecular graphics & modelling 20090101

Title: Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20081001

Title: Corticotropin-releasing hormone receptor 1 coexists with endothelin-1 and modulates its mRNA expression and release in rat paraventricular nucleus during hypoxia.

Journal: Neuroscience 20080409

Title: Blockade of the corticotropin releasing factor type 1 receptor attenuates elevated ethanol drinking associated with drinking in the dark procedures.

Journal: Alcoholism, clinical and experimental research 20080201

Title: The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice.

Journal: Alcoholism, clinical and experimental research 20080201

Title: Corticotropin releasing factor-1 receptor antagonist, CP-154,526, blocks the expression of ethanol-induced behavioral sensitization in DBA/2J mice.

Journal: Neuroscience 20071130

Title: Effects of hypoxia on glucose, insulin, glucagon, and modulation by corticotropin-releasing factor receptor type 1 in the rat.

Journal: Endocrinology 20070701

Title: An arginine vasopressin V1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070413

Title: Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression.

Journal: Pharmacology, biochemistry, and behavior 20070301

Title: CP-154,526, a CRF type-1 receptor antagonist, attenuates the cue-and methamphetamine-induced reinstatement of extinguished methamphetamine-seeking behavior in rats.

Journal: Psychopharmacology 20070201

Title: Endogenous expression and in vitro study of CRF-related peptides and CRF receptors in the rat gastric antrum.

Journal: Peptides 20060601

Title: The corticotropin-releasing factor (CRF)(1) receptor antagonists CP154,526 and DMP695 inhibit light-induced phase advances of hamster circadian activity rhythms.

Journal: Brain research 20060414

Title: Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats.

Journal: Psychopharmacology 20060301

Title: Suppression of adrenocorticotrophic hormone secretion by simultaneous antagonism of vasopressin 1b and CRH-1 receptors on three different stress models.

Journal: Neuroendocrinology 20060101

Title: Effects of CP 154,526, a CRF1 receptor antagonist, on behavioral responses to cocaine in rats.

Journal: Neuropeptides 20051001

Title: Effects of corticotropin-releasing hormone receptor antagonists on cocaine-induced dopamine overflow in the medial prefrontal cortex and nucleus accumbens of rats.

Journal: Synapse (New York, N.Y.) 20050915

Title: Prior multiple ethanol withdrawals enhance stress-induced anxiety-like behavior: inhibition by CRF1- and benzodiazepine-receptor antagonists and a 5-HT1a-receptor agonist.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050901

Title: Corticotropin-releasing factor receptor subtypes mediating nutritional suppression of estrous behavior in Syrian hamsters.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050801

Title: The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats.

Journal: Psychopharmacology 20050701

Title: Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels.

Journal: Neuropharmacology 20050601

Title: CRF receptor type 1 mediates continual hypoxia-induced CRF peptide and CRF mRNA expression increase in hypothalamic PVN of rats.

Journal: Peptides 20050401

Title: CRF1 receptor antagonist CP-154,526 reduces cardiovascular responses during acute psychological stress in rabbits.

Journal: Brain research 20040813

Title: Transcriptional regulation of the CART promoter in CATH.a cells.

Journal: Brain research. Molecular brain research 20040705

Title: Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release.

Journal: The European journal of neuroscience 20040701

Title: CRF-receptor 1 blockade attenuates acute posttraumatic hyperglycemia in rats.

Journal: The Journal of surgical research 20040601

Title: Antidepressant effects of citalopram and CRF receptor antagonist CP-154,526 in a rat model of depression.

Journal: European journal of pharmacology 20040525

Title: Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040401

Title: Effect of long-term blockade of CRF(1) receptors on exploratory behaviour, monoamines and transcription factor AP-2.

Journal: Pharmacology, biochemistry, and behavior 20040401

Title: Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors.

Journal: Neuropharmacology 20031001

Title: Extrahypothalamic corticotropin-releasing hormone mediates (-)-nicotine-induced elevation of plasma corticosterone in rats.

Journal: European journal of pharmacology 20030725

Title: Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes.

Journal: Journal of neurochemistry 20030301

Title: The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review.

Journal: CNS drug reviews 20030101

Title: CRF1-receptor antagonist CP-154526 reduces alerting-related cutaneous vasoconstriction in conscious rabbits.

Journal: Neuroscience 20030101

Title: Peripheral CRF activates myenteric neurons in the proximal colon through CRF(1) receptor in conscious rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020501

Title: Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats.

Journal: Psychopharmacology 20020501

Title: Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201

Title: Human urocortin II, a new CRF-related peptide, displays selective CRF(2)-mediated action on gastric transit in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020101

Title: Effects of CP-154,526 on responding during extinction from cocaine self-administration in rats.

Journal: European journal of pharmacology 20011130

Title: Peripheral urocortin inhibits gastric emptying and food intake in mice: differential role of CRF receptor 2.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011101

Title: Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agent.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20011001

Title: Role of brain arachidonic acid cascade on central CRF1 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.

Journal: European journal of pharmacology 20010511

Title: Corticotropin-releasing factor receptor type 1 mediates stress-induced relapse to cocaine-conditioned place preference in rats.

Journal: European journal of pharmacology 20010301

Title: Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20001101

Title: 4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2, 4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: a potent, orally bioavailable CRF(1) receptor antagonist.

Journal: Journal of medicinal chemistry 20000210

Title: A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity.

Journal: European journal of pharmacology 19960808

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