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2586-96-1,MFCD03427702
Catalog No.:AA007NHF

2586-96-1 | Liensinine

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20mg
in stock  
$636.00   $445.00
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50mg
analytical standard,≥98%
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$1,531.00   $1,072.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007NHF
Chemical Name:
Liensinine
CAS Number:
2586-96-1
Molecular Formula:
C37H42N2O6
Molecular Weight:
610.7392
MDL Number:
MFCD03427702
SMILES:
COc1cc2CCN([C@@H](c2cc1Oc1cc(ccc1O)C[C@H]1N(C)CCc2c1cc(OC)c(c2)OC)Cc1ccc(cc1)O)C
Properties
Computed Properties
 
Complexity:
917  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
6.4  

Literature

Title: Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.

Journal: Chemico-biological interactions 20141205

Title: Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study.

Journal: Arzneimittel-Forschung 20110101

Title: Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography.

Journal: Journal of separation science 20090701

Title: [Metabolic products and pathway of neferine in rat liver].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20071001

Title: [Determination of three alkaloids in total alkaloids exfracts from Lotus plumule by RP-HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

Title: [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

Title: Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20070104

Title: Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice.

Journal: Planta medica 20050301

Title: Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids.

Journal: Bioorganic & medicinal chemistry 20050117

Title: Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79.

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