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259793-96-9,MFCD12032148
Catalog No.:AA002R6Y

259793-96-9 | 2-Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-

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10mg
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25mg
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5g
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002R6Y
Chemical Name:
2-Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-
CAS Number:
259793-96-9
Molecular Formula:
C5H4FN3O2
Molecular Weight:
157.1026
MDL Number:
MFCD12032148
SMILES:
Fc1c[nH]c(=O)c(n1)C(=O)N
Properties
Computed Properties
 
Complexity:
282  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
-0.6  

Downstream Synthesis Route
10416-59-8    259793-96-9   
6-fluoro-3-((trimethylsilyl)oxy)pyrazine-2-carboxamide 

[1]Patent:EP1417967,2004,A1.Locationinpatent:Page/Pagecolumn53

[1]Patent:US2003/130213,2003,A1

[2]Patent:US2011/275817,2011,A1

[3]Patent:CN107641106,2018,A

6-fluoro-3-methoxy-2-pyrazinecarboxamide 
  259793-96-9 

[1]Patent:US2003/130213,2003,A1

[2]Patent:US2002/13316,2002,A1

[1]Patent:US2003/130213,2003,A1

Literature

Title: Favipiravir (T-705) inhibits in vitro norovirus replication.

Journal: Biochemical and biophysical research communications 20120810

Title: Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.

Journal: Antiviral research 20120401

Title: [Anti-influenza virus agent].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20120401

Title: [New antiviral agents of influenza].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20120401

Title: A novel small molecule inhibitor of influenza A viruses that targets polymerase function and indirectly induces interferon.

Journal: PLoS pathogens 20120401

Title: Viral hemorrhagic fevers: advancing the level of treatment.

Journal: BMC medicine 20120101

Title: Monoclonal antibodies targeting the synthetic peptide corresponding to the polybasic cleavage site on H5N1 influenza hemagglutinin.

Journal: Journal of biomedical science 20120101

Title: Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever.

Journal: PLoS neglected tropical diseases 20111001

Title: Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir.

Journal: Antiviral chemistry & chemotherapy 20110512

Title: Caffeoylquinic acids are major constituents with potent anti-influenza effects in brazilian green propolis water extract.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Perspective: emerging challenges in the treatment of influenza and parainfluenza in transplant patients.

Journal: Advances in virology 20110101

Title: Viral replication rate regulates clinical outcome and CD8 T cell responses during highly pathogenic H5N1 influenza virus infection in mice.

Journal: PLoS pathogens 20101001

Title: [Present and future in development of new anti-influenza drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses.

Journal: PLoS pathogens 20100801

Title: Combination chemotherapy for influenza.

Journal: Viruses 20100801

Title: Antiviral strategies for pandemic and seasonal influenza.

Journal: Viruses 20100801

Title: Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models.

Journal: Antiviral research 20100501

Title: A Potent, Broad-Spectrum Antiviral Agent that Targets Viral Membranes.

Journal: Viruses 20100501

Title: Development of a new tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog.

Journal: PloS one 20100101

Title: Inhibitors of foot and mouth disease virus targeting a novel pocket of the RNA-dependent RNA polymerase.

Journal: PloS one 20100101

Title: Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells.

Journal: The Journal of antimicrobial chemotherapy 20091001

Title: T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections.

Journal: Antiviral research 20090601

Title: Effect of T-705 treatment on western equine encephalitis in a mouse model.

Journal: Antiviral research 20090601

Title: Developing new antiviral agents for influenza treatment: what does the future hold?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090101

Title: Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents.

Journal: Antiviral research 20081201

Title: Current and future antiviral therapy of severe seasonal and avian influenza.

Journal: Antiviral research 20080401

Title: Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin.

Journal: PloS one 20080101

Title: In vitro and in vivo activities of T-705 against arenavirus and bunyavirus infections.

Journal: Antimicrobial agents and chemotherapy 20070901

Title: Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice.

Journal: Antimicrobial agents and chemotherapy 20070301

Title: Strategies of development of antiviral agents directed against influenza virus replication.

Journal: Current pharmaceutical design 20070101

Title: Mechanism of action of T-705 against influenza virus.

Journal: Antimicrobial agents and chemotherapy 20050301

Title: In vitro and in vivo activities of T-705 and oseltamivir against influenza virus.

Journal: Antiviral chemistry & chemotherapy 20030901

Title: In vitro and in vivo activities of anti-influenza virus compound T-705.

Journal: Antimicrobial agents and chemotherapy 20020401

Title: Protein and energy utilization by the insect, Argyrotaenia velutinana (Walker), fed diets containing graded levels of an amino acid mixture.

Journal: Comparative biochemistry and physiology. A, Comparative physiology 19751201

Title: Furuta Y, et al. Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res. 2013 Nov;100(2):446-54.

Title: Rocha-Pereira J, et al. Favipiravir (T-705) inhibits in vitro norovirus replication. Biochem Biophys Res Commun. 2012 Aug 10;424(4):777-80.

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Tags:259793-96-9 Molecular Formula|259793-96-9 MDL|259793-96-9 SMILES|259793-96-9 2-Pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-