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260264-93-5,MFCD19381832
Catalog No.:AA002RC0

260264-93-5 | GI 254023X

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
in stock  
$62.00   $43.00
- +
5mg
≥98%
in stock  
$238.00   $166.00
- +
10mg
≥98%
in stock  
$393.00   $275.00
- +
25mg
≥98%
in stock  
$685.00   $479.00
- +
100mg
98% (HPLC)
in stock  
$2,532.00   $1,773.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002RC0
Chemical Name:
GI 254023X
CAS Number:
260264-93-5
Molecular Formula:
C21H33N3O4
Molecular Weight:
391.5044
MDL Number:
MFCD19381832
SMILES:
CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]([C@@H](N(C=O)O)C)CCCc1ccccc1
Properties
Computed Properties
 
Complexity:
512  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
2.9  

Literature

Title: The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.

Journal: Journal of cellular physiology 20180301

Title: Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.

Journal: Oncology reports 20121101

Title: Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.

Journal: Blood 20120503

Title: Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection.

Journal: The Journal of investigative dermatology 20120501

Title: An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.

Journal: Nature neuroscience 20120501

Title: Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20120401

Title: Improved synthesis of ADAM10 inhibitor GI254023X.

Journal: Neuro-degenerative diseases 20100101

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

Journal: Combinatorial chemistry & high throughput screening 20050301

Title: The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Journal: Blood 20030815

Title: CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701

Title: Verena V. Metz, et al. Induction of RAGE Shedding by Activation of G Protein-Coupled Receptors. PLoS One. 2012.

Title: M J M Gooden, et al. Elevated serum CXCL16 is an independent predictor of poor survival in ovarian cancer and may reflect pro-metastatic ADAM protease activity. British Journal of Cancer (2014) 110, 1535–1544.

Title: N Milosch, et al. Holo-APP and G-protein-mediated signaling are required for sAPPa-induced activation of the Akt. Cell Death Dis. 2014 Aug 28;5:e1391.

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