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[1]CurrentPatentAssignee:SAMILABSLIMITED-US2008/26017,2008,A1Locationinpatent:Page/Pagecolumn7
[1]CurrentPatentAssignee:PHARMASE-EP1205471,2002,A1Locationinpatent:Page6
Title: Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130901
Title: A reliable solid phase microextraction-gas chromatography-triple quadrupole mass spectrometry method for the assay of selenomethionine and selenomethylselenocysteine in aqueous extracts: difference between selenized and not-enriched selenium potatoes.
Journal: Analytica chimica acta 20121017
Title: Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies.
Journal: Biochemistry 20120124
Title: Analysis of selenomethylselenocysteine and selenomethionine by LC-ESI-MS/MS with diethyl ethoxymethylenemalonate derivatization.
Journal: The Analyst 20111221
Title: Augmented therapeutic efficacy of irinotecan is associated with enhanced drug accumulation.
Journal: Cancer letters 20111208
Title: Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.
Journal: Oncotarget 20111201
Title: Chemical form of selenium affects its uptake, transport, and glutathione peroxidase activity in the human intestinal Caco-2 cell model.
Journal: Biological trace element research 20111101
Title: Methyl selenocysteine: single-dose pharmacokinetics in men.
Journal: Cancer prevention research (Philadelphia, Pa.) 20111101
Title: Biofortification of tomato (Solanum lycopersicum) fruit with the anticancer compound methylselenocysteine using a selenocysteine methyltransferase from a selenium hyperaccumulator.
Journal: Journal of agricultural and food chemistry 20111026
Title: Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium.
Journal: The Prostate 20110915
Title: Distribution of Se and its species in Myriophyllum spicatum and Ceratophyllum demersum growing in water containing Se (VI).
Journal: Chemosphere 20110901
Title: The von Hippel-Lindau (VHL) tumor-suppressor gene is down-regulated by selenium deficiency in Caco-2 cells and rat colon mucosa.
Journal: Biological trace element research 20110801
Title: Interventions that induce modifications in the tumor microenvironment.
Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20110801
Title: Methylselenocysteine: a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs.
Journal: Expert opinion on drug delivery 20110601
Title: Anti-hemolytic and peroxyl radical scavenging activity of organoselenium compounds: an in vitro study.
Journal: Biological trace element research 20110501
Title: Se-methylselenocysteine inhibits lipopolysaccharide-induced NF-κB activation and iNOS induction in RAW 264.7 murine macrophages.
Journal: Molecular nutrition & food research 20110501
Title: Metabolic and bioprocess engineering for production of selenized yeast with increased content of seleno-methylselenocysteine.
Journal: Metabolic engineering 20110501
Title: Uptake, distribution, and speciation of selenoamino acids by human cancer cells: X-ray absorption and fluorescence methods.
Journal: Biochemistry 20110315
Title: Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer.
Journal: Anticancer research 20110201
Title: Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds.
Journal: Nutrition and cancer 20110101
Title: Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells.
Journal: The Journal of biological chemistry 20101022
Title: Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha.
Journal: Cancer chemotherapy and pharmacology 20101001
Title: Simultaneous analysis of mercury and selenium species including chiral forms of selenomethionine in human urine and serum by HPLC column-switching coupled to ICP-MS.
Journal: The Analyst 20101001
Title: Differential apoptotic response of human cancer cells to organoselenium compounds.
Journal: Cancer chemotherapy and pharmacology 20100801
Title: Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model.
Journal: Cancer prevention research (Philadelphia, Pa.) 20100801
Title: Interleukin-10 delivery via mesenchymal stem cells: a novel gene therapy approach to prevent lung ischemia-reperfusion injury.
Journal: Human gene therapy 20100601
Title: Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo.
Journal: Cancer prevention research (Philadelphia, Pa.) 20100501
Title: Selenium compounds activate early barriers of tumorigenesis.
Journal: The Journal of biological chemistry 20100416
Title: Selenium, but not lycopene or vitamin E, decreases growth of transplantable dunning R3327-H rat prostate tumors.
Journal: PloS one 20100101
Title: Survivin gene silencing sensitizes prostate cancer cells to selenium growth inhibition.
Journal: BMC cancer 20100101
Title: Selenium hyperaccumulation offers protection from cell disruptor herbivores.
Journal: BMC ecology 20100101
Title: Combination of methylselenocysteine with tamoxifen inhibits MCF-7 breast cancer xenografts in nude mice through elevated apoptosis and reduced angiogenesis.
Journal: Breast cancer research and treatment 20091101
Title: Speciation analysis of selenium metabolites in urine and breath by HPLC- and GC-inductively coupled plasma-MS after administration of selenomethionine and methylselenocysteine to rats.
Journal: Chemical research in toxicology 20091101
Title: In vitro radioprotection studies of organoselenium compounds: differences between mono- and diselenides.
Journal: Radiation and environmental biophysics 20091101
Title: Speciation of selenium dietary supplements; formation of S-(methylseleno)cysteine and other selenium compounds.
Journal: Analytica chimica acta 20091012
Title: Dietary supplementation with selenomethylselenocysteine produces a differential proteomic response.
Journal: The Journal of nutritional biochemistry 20091001
Title: Antiproliferative effects of selenium compounds in colon cancer cells: comparison of different cytotoxicity assays.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20091001
Title: Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor.
Journal: Clinical colorectal cancer 20090701
Title: Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
Journal: Transgenic research 20090601
Title: Separation and determination of seleno amino acids using gas chromatography hyphenated with inductively coupled plasma mass spectrometry after hollow fiber liquid phase microextraction.
Journal: Journal of mass spectrometry : JMS 20090501
Title: Se-methylselenocysteine sensitized TRAIL-mediated apoptosis via down-regulation of Bcl-2 expression.
Journal: International journal of oncology 20090501
Title: Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit.
Journal: Cancer prevention research (Philadelphia, Pa.) 20090501
Title: Selenium metabolism in rats with long-term ingestion of Se-methylselenocysteine using enriched stable isotopes.
Journal: The Journal of toxicological sciences 20090401
Title: Differential action of methylselenocysteine in control and alloxan-diabetic rabbits.
Journal: Chemico-biological interactions 20090127
Title: Differential sensitivity of various human tumour-derived cell types to apoptosis by organic derivatives of selenium.
Journal: The British journal of nutrition 20090101
Title: Organic and inorganic selenium compounds produce different protein patterns in the blood plasma of rats.
Journal: Biological research 20090101
Title: Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study.
Journal: American heart journal 20081201
Title: Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells.
Journal: Cancer letters 20080928
Title: Long exposure of non-cytotoxic concentrations of methylselenol suppresses the invasive potential of B16F10 melanoma.
Journal: Oncology reports 20080901
Title: Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts.
Journal: Neoplasia (New York, N.Y.) 20080801
Title: Chemopreventive doses of methylselenocysteine alter circadian rhythm in rat mammary tissue.
Journal: Cancer prevention research (Philadelphia, Pa.) 20080701
Title: Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080615
Title: Subchronic oral toxicity studies of Se-methylselenocysteine, an organoselenium compound for breast cancer prevention.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080301
Title: Preferential organ distribution of methylselenol source Se-methylselenocysteine relative to methylseleninic acid.
Journal: Toxicology and applied pharmacology 20080215
Title: [Effects of Se-methylselenocysteine on biological behavior of and matrix metalloproteinase-2 expression in human breast cancer MDA-MB-231 cells].
Journal: Ai zheng = Aizheng = Chinese journal of cancer 20080201
Title: Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080101
Title: Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide.
Journal: Analytical and bioanalytical chemistry 20071201
Title: Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent.
Journal: Biochemical pharmacology 20070501
Title: Selenium accumulation protects plants from herbivory by Orthoptera via toxicity and deterrence.
Journal: The New phytologist 20070101
Title: Mechanism for proliferation inhibition by various selenium compounds and selenium-enriched broccoli extract in rat glial cells.
Journal: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20061201
Title: Metabolism of 76Se-methylselenocysteine compared with that of 77Se-selenomethionine and 82Se-selenite.
Journal: Toxicology and applied pharmacology 20061201
Title: Selenium-tolerant diamondback moth disarms hyperaccumulator plant defense.
Journal: Current biology : CB 20061121
Title: The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells.
Journal: Molecular cancer therapeutics 20061001
Title: Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA).
Journal: The Prostate 20060701
Title: Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1alpha expression, resulting in reduced angiogenesis.
Journal: Oncogene 20060420
Title: Se-methylselenocysteine enhances PMA-mediated CD11c expression via phospholipase D1 activation in U937 cells.
Journal: Immunobiology 20060101
Title: [Effects of selenium and B-27 supplements on viability and differentiation of neural stem cell in newborn rat].
Journal: Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20050901
Title: Selenium protects against toxicity induced by anticancer drugs and augments antitumor activity: a highly selective, new, and novel approach for the treatment of solid tumors.
Journal: Clinical colorectal cancer 20050701
Title: Molecular and biochemical characterization of the selenocysteine Se-methyltransferase gene and Se-methylselenocysteine synthesis in broccoli.
Journal: Plant physiology 20050501
Title: Irinotecan pharmacokinetic and pharmacogenomic alterations induced by methylselenocysteine in human head and neck xenograft tumors.
Journal: Molecular cancer therapeutics 20050501
Title: Se-methylselenocysteine inhibits phosphatidylinositol 3-kinase activity of mouse mammary epithelial tumor cells in vitro.
Journal: Breast cancer research : BCR 20050101
Title: Chemical forms of selenium for cancer prevention.
Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20050101
Title: Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine.
Journal: Biochemistry 20041026
Title: Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Journal: Molecular pharmacology 20040701
Title: Identification and synthesis of a novel selenium-sulfur amino acid found in selenized yeast: Rapid indirect detection NMR methods for characterizing low-level organoselenium compounds in complex matrices.
Journal: Journal of agricultural and food chemistry 20040616
Title: Overexpression of selenocysteine methyltransferase in Arabidopsis and Indian mustard increases selenium tolerance and accumulation.
Journal: Plant physiology 20040501
Title: Selective modulation of the therapeutic efficacy of anticancer drugs by selenium containing compounds against human tumor xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040401
Title: Methioninase and selenomethionine but not Se-methylselenocysteine generate methylselenol and superoxide in an in vitro chemiluminescent assay: implications for the nutritional carcinostatic activity of selenoamino acids.
Journal: Biochemical pharmacology 20040201
Title: Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase.
Journal: BMC plant biology 20040101
Title: Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine.
Journal: Breast cancer research : BCR 20040101
Title: Induction of apoptosis by Se-MSC in U937 human leukemia cells through release of cytochrome c and activation of caspases and PKC-delta: mutual regulation between caspases and PKC-delta via a positive feedback mechanism.
Journal: International journal of molecular medicine 20031101
Title: Characteristics of selenazolidine prodrugs of selenocysteine: toxicity and glutathione peroxidase induction in V79 cells.
Journal: Journal of medicinal chemistry 20030717
Title: Incorporation of selenomethionine into proteins through selenohomocysteine-mediated ligation.
Journal: Angewandte Chemie (International ed. in English) 20030525
Title: Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells.
Journal: Cancer letters 20020808
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Se-methylselenocysteine induces apoptosis mediated by reactive oxygen species in HL-60 cells.
Journal: Free radical biology & medicine 20010815
Title: Se-methylselenocysteine induces apoptosis through caspase activation in HL-60 cells.
Journal: Carcinogenesis 20010401
Title: Characterization of the biological activity of gamma-glutamyl-Se-methylselenocysteine: a novel, naturally occurring anticancer agent from garlic.
Journal: Cancer research 20010401
Title: Characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy.
Journal: Biochemistry 20010130
Title: Methylselenocysteine modulates proliferation and apoptosis biomarkers in premalignant lesions of the rat mammary gland.
Journal: Anticancer research 20010101
Title: Se-methylselenocysteine activates caspase-3 in mouse mammary epithelial tumor cells in vitro.
Journal: BioFactors (Oxford, England) 20010101
Title: Chemistry and biological activity of novel selenium-containing compounds.
Journal: Advances in experimental medicine and biology 20010101
Title: Se-methylselenocysteine: a new compound for chemoprevention of breast cancer.
Journal: Nutrition and cancer 20010101
Title: Dimethyldiselenide and methylseleninic acid generate superoxide in an in vitro chemiluminescence assay in the presence of glutathione: implications for the anticarcinogenic activity of L-selenomethionine and L-Se-methylselenocysteine.
Journal: Nutrition and cancer 20010101
Title: Effects of methylselenocysteine on PKC activity, cdk2 phosphorylation and gadd gene expression in synchronized mouse mammary epithelial tumor cells.
Journal: Cancer letters 19991115
