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26130-02-9,MFCD00030234
Catalog No.:AA002RPI

26130-02-9 | Frentizole

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5mg
98%(HPLC)
in stock  
$121.00   $85.00
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10mg
98%(HPLC)
in stock  
$215.00   $150.00
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25mg
98%(HPLC)
in stock  
$366.00   $256.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002RPI
Chemical Name:
Frentizole
CAS Number:
26130-02-9
Molecular Formula:
C15H13N3O2S
Molecular Weight:
299.3476
MDL Number:
MFCD00030234
SMILES:
COc1ccc2c(c1)sc(n2)NC(=O)Nc1ccccc1
Properties
Computed Properties
 
Complexity:
363  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.2  

Downstream Synthesis Route

[1]Benek,Ondrej;Hroch,Lukas;Aitken,Laura;Dolezal,Rafael;Hughes,Rebecca;Guest,Patrick;Benkova,Marketa;Soukup,Ondrej;Musil,Karel;Kuca,Kamil;Smith,TerryK.;Gunn-Moore,Frank;Musilek,Kamil[MedicinalChemistry,2017,vol.13,#4,p.345-358]

[1]Benek,Ondrej;Hroch,Lukas;Aitken,Laura;Dolezal,Rafael;Hughes,Rebecca;Guest,Patrick;Benkova,Marketa;Soukup,Ondrej;Musil,Karel;Kuca,Kamil;Smith,TerryK.;Gunn-Moore,Frank;Musilek,Kamil[MedicinalChemistry,2017,vol.13,#4,p.345-358]

[1]Salah,Mohamed;Abdel-Halim,Mohammad;Engel,Matthias[MedChemComm,2018,vol.9,#6,p.1045-1053]

[2]Chen,Jin-Yu;Selvaraju,Manikandan;Lin,Yen-Tzu;Dhole,Sandip;Lin,Chih-Yu;Sun,Chung-Ming[JournalofOrganicChemistry,2020,vol.85,#8,p.5570-5579]

[1]Salah,Mohamed;Abdel-Halim,Mohammad;Engel,Matthias[MedChemComm,2018,vol.9,#6,p.1045-1053]

Literature

Title: Identification of small-molecule inhibitors of the Abeta-ABAD interaction.

Journal: Bioorganic & medicinal chemistry letters 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Meisel AD, et al. Effect of frentizole on mitogen-induced blastogenesis in human lymphocytes. J Immunopharmacol. 1979;1(4):483-95.

Title: Walker SE, et al. Prolonged lifespans in female NZB/NZW mice treated with the experimental immunoregulatory drug frentizole. Arthritis Rheum. 1982 Nov;25(11):1291-7.

Title: Yuli Xie, et al. Identification of small-molecule inhibitors of the Abeta-ABAD interaction. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4657-60.

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SDS
Tags:26130-02-9 Molecular Formula|26130-02-9 MDL|26130-02-9 SMILES|26130-02-9 Frentizole