261365-11-1
[1]Locationinpatent:experimentalpartDang,Qun;Kasibhatla,SrinivasRao;Jiang,Tao;Fan,Kevin;Liu,Yan;Taplin,Frank;Schulz,William;Cashion,DanielK.;Reddy,K.Raja;VanPoelje,PaulD.;Fujitaki,JamesM.;Potter,ScottC.;Erion,MarkD.[JournalofMedicinalChemistry,2008,vol.51,#14,p.4331-4339]
[2]Locationinpatent:schemeortableDang,Qun;Liu,Yan;Cashion,DanielK.;Kasibhatla,SrinivasRao;Jiang,Tao;Taplin,Frank;Jacintho,JasonD.;Li,Haiqing;Sun,Zhili;Fan,Yi;Dare,Jay;Tian,Feng;Li,Wenyu;Gibson,Tony;Lemus,Robert;VanPoelje,PaulD.;Potter,ScottC.;Erion,MarkD.[JournalofMedicinalChemistry,2011,vol.54,#1,p.153-165]
Title: Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Journal: Journal of medicinal chemistry 20110113
Title: Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.
Journal: Endocrinology 20101001
Title: Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics.
Journal: Journal of medicinal chemistry 20100114
Title: A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase.
Journal: Bioorganic & medicinal chemistry 20090601
Title: Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors.
Journal: Journal of medicinal chemistry 20080724
Title: Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.
Title: Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151(10):4688-95.
