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261766-32-9,MFCD02683391
Catalog No.:AA002S08

261766-32-9 | 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-

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Purity
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1mg
≥98%
in stock  
$26.00   $18.00
- +
5mg
≥98%
in stock  
$105.00   $73.00
- +
10mg
≥98%
in stock  
$185.00   $129.00
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50mg
≥98%
in stock  
$790.00   $553.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002S08
Chemical Name:
1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-
CAS Number:
261766-32-9
Molecular Formula:
C27H25ClN2O3
Molecular Weight:
460.9520
MDL Number:
MFCD02683391
SMILES:
COc1ccc2c(c1)c(CC(=O)NCCc1ccccc1)c(n2C(=O)c1ccc(cc1)Cl)C
Properties
Computed Properties
 
Complexity:
660  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
6  

Literature

Title: Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.

Journal: Bioorganic & medicinal chemistry 20100115

Title: Utility of MetaSite in improving metabolic stability of the neutral indomethacin amide derivative and selective cyclooxygenase-2 inhibitor 2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501

Title: Structural and functional basis of cyclooxygenase inhibition.

Journal: Journal of medicinal chemistry 20070405

Title: Inhibition of cyclooxygenase with indomethacin phenethylamide reduces atherosclerosis in apoE-null mice.

Journal: Biochemical pharmacology 20050801

Title: Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040101

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SDS
Tags:261766-32-9 Molecular Formula|261766-32-9 MDL|261766-32-9 SMILES|261766-32-9 1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-