Catalog No.:AA002T7P

2645-32-1 | PR-619

Name: Name:PR-619
Brand: AABLOCKS
SKU: AA002T7P
Availability: InStock
Rating: 90 (10 reviews)

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Purity

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Quantity

1mg

98%

in stock

$19.00 $14.00

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10mg

98%

in stock

$68.00 $48.00

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50mg

98%

in stock

$151.00 $106.00

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100mg

98%

in stock

$217.00 $152.00

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95%

in stock

$1,060.00 $742.00

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
Request for Quotation
Download SDS

Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA002T7P

Chemical Name:

PR-619

CAS Number:

2645-32-1

Molecular Formula:

C7H5N5S2

Molecular Weight:

223.2781

MDL Number:

MFCD00830384

SMILES:

N#CSc1cc(SC#N)c(nc1N)N

Properties

Form:

Solid

MP:

210°C

Storage:

Keep in dry area;2-8℃;

Computed Properties

Complexity:

261

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

1.3

Upstream Synthesis Route

141-86-6

2645-32-1

[1]JournaloftheAmericanChemicalSociety,2002,vol.124,#32,p.9498-9509

Downstream Synthesis Route

108-24-7

2645-32-1

94785-86-1

[1]JournaloftheChemicalSociety,1962,p.3464-3468

108-24-7

2645-32-1

55526-64-2

[1]Sovietprogressinchemistry,1975,vol.41,p.59-60 UkrainskiiKhimicheskiiZhurnal(RussianEdition),1975,vol.41,p.283-284

98-88-4

2645-32-1

99000-60-9

[1]JournaloftheChemicalSociety,1962,p.3464-3468

2645-32-1

27052-52-4

[1]JournaloftheChemicalSociety,1962,p.3464-3468

2645-32-1

76942-25-1

[1]JournaloftheChemicalSociety.Chemicalcommunications,1980,p.1139-1140

Literature

Title: Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.

Journal: Viruses 20170801

Title: Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1β in the HUVEC Endothelial Cell Line.

Journal: Chemical research in toxicology 20160321

Title: The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases.

Journal: Biochimica et biophysica acta 20121101

Title: Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.

Journal: Molecular & cellular proteomics : MCP 20120501

Title: Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

Journal: Chemistry & biology 20111123

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SDS