Home Carboxes 265129-71-3
265129-71-3,MFCD06798379
Catalog No.:AA002TG2

265129-71-3 | 2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$203.00   $142.00
- +
10mg
≥98%
in stock  
$305.00   $213.00
- +
25mg
≥98%
in stock  
$568.00   $397.00
- +
50mg
98%
in stock  
$1,107.00   $775.00
- +
100mg
98%
in stock  
$1,574.00   $1,102.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002TG2
Chemical Name:
2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
CAS Number:
265129-71-3
Molecular Formula:
C29H46N2O3S
Molecular Weight:
502.7521
MDL Number:
MFCD06798379
SMILES:
O=C(N(CCc1ccc(cc1)SC(C(=O)O)(C)C)CCCCC1CCCCC1)NC1CCCCC1
Properties
Properties
 
Form:
Solid  
MP:
156 - 157°C  
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
636  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
XLogP3:
8  

Literature

Title: The urinary metabolites of DINCH(®) have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.

Journal: Toxicology letters 20180501

Title: Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR.

Journal: Toxicology letters 20170805

Title: Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression.

Journal: The Journal of biological chemistry 20160715

Title: Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices.

Journal: PloS one 20140101

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths.

Journal: Toxicology letters 20130412

Title: Long-term stability of primary rat hepatocytes in micropatterned cocultures.

Journal: Journal of biochemical and molecular toxicology 20130301

Title: Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20130101

Title: Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells.

Journal: The Journal of toxicological sciences 20130101

Title: Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust.

Journal: Environmental health perspectives 20121201

Title: Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes.

Journal: Molecular biology reports 20121201

Title: Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Journal: Bioorganic & medicinal chemistry letters 20121001

Title: Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.

Journal: Journal of medicinal chemistry 20120614

Title: Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPARα) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120601

Title: A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

Journal: PloS one 20120101

Title: Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells.

Journal: Chemistry & biology 20111123

Title: Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.

Journal: Lipids 20111101

Title: Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism.

Journal: European journal of medicinal chemistry 20111001

Title: Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.

Journal: Journal of natural products 20110826

Title: Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110601

Title: Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes.

Journal: Journal of lipid research 20110501

Title: Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.

Journal: Biochemical and biophysical research communications 20110422

Title: Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.

Journal: Journal of medicinal chemistry 20110210

Title: Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs.

Journal: Journal of cellular biochemistry 20110201

Title: PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A2 in astrocytes; inhibition in naïve, untreated cells and enhancement in LPS-stimulated cells.

Journal: Journal of neurochemistry 20101001

Title: Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.

Journal: Molecular pharmacology 20100901

Title: Peroxisome proliferator-activated receptors gamma and alpha agonists stimulate cardiac glucose uptake via activation of AMP-activated protein kinase.

Journal: The Journal of nutritional biochemistry 20100701

Title: Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator.

Journal: Bioorganic & medicinal chemistry letters 20100415

Title: Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain.

Journal: Protein expression and purification 20100401

Title: Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

Journal: Chemical research in toxicology 20100315

Title: Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes.

Journal: Endocrinology 20100101

Title: Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20091208

Title: Synthesis and biological evaluation of 2-heteroarylthioalkanoic acid analogues of clofibric acid as peroxisome proliferator-activated receptor alpha agonists.

Journal: Journal of medicinal chemistry 20091022

Title: Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes.

Journal: Toxicology and applied pharmacology 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.

Journal: Molecular pharmacology 20090801

Title: Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia.

Journal: European journal of pharmacology 20090624

Title: Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine.

Journal: European journal of gastroenterology & hepatology 20090601

Title: Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.

Journal: Endocrinology 20090401

Title: Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans.

Journal: The Journal of endocrinology 20090201

Title: Thioredoxin-1 and its natural inhibitor, vitamin D3 up-regulated protein 1, are differentially regulated by PPARalpha in human macrophages.

Journal: Journal of molecular biology 20081219

Title: PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways.

Journal: Free radical biology & medicine 20081215

Title: Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents.

Journal: Bioorganic & medicinal chemistry 20081201

Title: 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation.

Journal: Journal of cellular physiology 20081101

Title: Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.

Journal: Journal of medicinal chemistry 20080828

Title: Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.

Journal: Journal of agricultural and food chemistry 20080514

Title: PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080301

Title: SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail.

Journal: Bioorganic & medicinal chemistry letters 20080201

Title: Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism.

Journal: Stem cells (Dayton, Ohio) 20080101

Title: PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages.

Journal: British journal of pharmacology 20071201

Title: Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons.

Journal: Journal of neurochemistry 20071101

Title: Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Journal: Circulation 20070918

Title: Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647.

Journal: European journal of pharmacology 20070702

Title: Identification of apolipoprotein A-I as a 'STOP' signal for myopia.

Journal: Molecular & cellular proteomics : MCP 20061101

Title: A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor alpha.

Journal: The Journal of organic chemistry 20060721

Title: Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.

Journal: Toxicology letters 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands.

Journal: Analytical biochemistry 20050901

Title: Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors.

Journal: The Journal of pharmacology and experimental therapeutics 20050701

Title: Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.

Journal: Neuropharmacology 20050601

Title: Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells.

Journal: The FEBS journal 20050601

Title: Peroxisome proliferator activated receptor delta (PPARdelta) agonist but not PPARalpha corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells.

Journal: The Journal of clinical endocrinology and metabolism 20050301

Title: Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy.

Journal: Molecular genetics and metabolism 20031201

Title: Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury.

Journal: Circulation 20031111

Title: Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030701

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells.

Journal: Diabetes 20020401

Title: Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis.

Journal: Bioorganic & medicinal chemistry letters 20010507

Title: A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

Journal: Diabetes 19990701

Title: Luo M, et al. IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes. Front Physiol. 2017 Feb 7;8:61.

Title: Tanaka S, et al. PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis. Biomed Res. 2016;37(3):167-78.

Title: Lebeck J, et al. Hepatic AQP9 expression in male rats is reduced in response to PPARα agonist treatment. Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G198-205.

Title: Lam VH, et al. Activating PPARα prevents post-ischemic contractile dysfunction in hypertrophied neonatal hearts. Circ Res. 2015 Jun 19;117(1):41-51.

Title: Brown PJ, et al. Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. Bioorg Med Chem Lett. 2001 May 7;11(9):1225-7.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 265129-71-3
Tags:265129-71-3 Molecular Formula|265129-71-3 MDL|265129-71-3 SMILES|265129-71-3 2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid