Home Other Building Blocks 26661-13-2
26661-13-2,MFCD00239434
Catalog No.:AA003595

26661-13-2 | N4-Benzoylcytosine

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25g
95%
in stock  
$13.00   $9.00
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100g
95%
in stock  
$26.00   $18.00
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500g
95
in stock  
$112.00   $78.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003595
Chemical Name:
N4-Benzoylcytosine
CAS Number:
26661-13-2
Molecular Formula:
C11H9N3O2
Molecular Weight:
215.2081
MDL Number:
MFCD00239434
SMILES:
O=c1nccc([nH]1)NC(=O)c1ccccc1
NSC Number:
211617
Properties
Properties
 
Form:
Solid  
MP:
>300 °C (dec.)(lit.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
354  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
0.3  

Upstream Synthesis Route

[1]Patent:US2011/245458,2011,A1,

[2]ChemicalCommunications,2017,vol.53,#64,p.8952-8955

[3]HeterocyclicCommunications,2007,vol.13,#4,p.251-256

[4]RussianJournalofOrganicChemistry,2008,vol.44,#3,p.358-361

[5]JournaloftheChemicalSociety,1956,p.2388,2392

[6]JournaloftheChemicalSociety,1958,p.3028,3032

[7]ChemistryofNaturalCompounds,1983,vol.19,#5,p.580-582

[8]KhimiyaPrirodnykhSoedinenii,1983,#5,p.617-619

[9]Patent:US6075143,2000,A,

[10]Chemistry-AEuropeanJournal,2011,vol.17,#51,p.14508-14517

[11]Patent:CN105541728,2016,A,.Locationinpatent:Paragraph0023;0024

[1]CollectionofCzechoslovakChemicalCommunications,1989,vol.54,#8,p.2190-2210

[2]Patent:CN105541728,2016,A,.Locationinpatent:Paragraph0027;0028

[1]Patent:US5714606,1998,A,

[2]Patent:US6184389,2001,B2,

[3]Patent:US6828427,2004,B1,

[1]ChemicalandPharmaceuticalBulletin,1989,vol.37,#9,p.2547-2549

Downstream Synthesis Route

[1]TetrahedronLetters,1994,vol.35,p.3243-3246

[2]Patent:CN111018912,2020,A.Locationinpatent:Paragraph0005;0016-0018

26661-13-2    88043-21-4   
N-tert-Butoxycarbonyl-cis-4-(N4-benzoylcytosin-1-yl)-L-prolinemethylester 
 
N-tert-Butoxycarbonyl-cis-4-4-(benzoylamino)pyrimidin-2-yloxy-L-prolinemethylester 

[1]JournaloftheChemicalSociety.PerkintransactionsI,1997,p.539-546

[1]CurrentPatentAssignee:GILEADSCIENCESINC-US2013/324709,2013,A1

[2]CurrentPatentAssignee:FUZHOUXINGCHENPHARAMCEUTICAL-CN106810515,2017,A

874638-93-4    26661-13-2    817204-32-3   
(2R,3R,4R,5S)-5-(4-benzoylamino-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-ylbenzoate 

[1]Maiti,Munmun;Maiti,Mohitosh;Rozenski,Jef;DeJonghe,Steven;Herdewijn,Piet[OrganicandBiomolecularChemistry,2015,vol.13,#18,p.5158-5174]

26661-13-2   
C27H25FO8S 
  817204-32-3 

[1]CurrentPatentAssignee:NANTONGCHANGYOOPHARMATECH;NANTONGCHANGYOUPHARMACEUTICALTECHNOLOGY-CN104610404,2016,BLocationinpatent:Paragraph0059;0060

Literature

Title: Synthesis and biological evaluation of 3'-C-ethynyl and 3'-C-(1,4-disubstituted-1,2,3-triazolo) double-headed pyranonucleosides.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120501

Title: Branched-chain C-cyano pyranonucleosides: synthesis of 3'-C-cyano & 3'-C-cyano-3'-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents.

Journal: European journal of medicinal chemistry 20111101

Title: Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: novel 5-fluorouracil analogs that target thymidylate synthase.

Journal: European journal of medicinal chemistry 20110401

Title: Novel nucleosides as potent influenza viral inhibitors.

Journal: Bioorganic & medicinal chemistry 20100901

Title: Synthesis of 4,6-dideoxy-3-fluoro-2-keto-beta-D-glucopyranosyl analogues of 5-fluorouracil, N6-benzoyl adenine, uracil, thymine, N4-benzoyl cytosine and evaluation of their antitumor activities.

Journal: Bioorganic chemistry 20100401

Title: Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: a convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N4-benzoyl cytosine and N6-benzoyl adenine.

Journal: European journal of medicinal chemistry 20091101

Title: Dideoxy fluoro-ketopyranosyl nucleosides as potent antiviral agents: synthesis and biological evaluation of 2,3- and 3,4-dideoxy-3-fluoro-4- and -2-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine.

Journal: European journal of medicinal chemistry 20090601

Title: Unsaturated fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-4-keto-beta-d-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine.

Journal: European journal of medicinal chemistry 20080201

Title: Fluoro-ketopyranosyl nucleosides: synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N4-benzoyl cytosine.

Journal: Bioorganic & medicinal chemistry 20070115

Title: 2'-chloro-2',3'-dideoxy-3'-fluoro-d-ribonucleosides: synthesis, stereospecificity, some chemical transformations, and conformational analysis.

Journal: The Journal of organic chemistry 20030725

Title: Diastereocontrolled synthesis of dinucleoside phosphorothioates using a novel class of activators, dialkyl(cyanomethyl)ammonium tetrafluoroborates.

Journal: Journal of the American Chemical Society 20020508

Title: Synthesis and biological evaluation of novel thioapio dideoxynucleosides.

Journal: Bioorganic & medicinal chemistry 20020501

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