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27061-78-5,MFCD00151517
Catalog No.:AA0038RN

27061-78-5 | Alamethicin (U-22324)

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1mg
≥90% (mixture of isoforms)
in stock  
$63.00   $44.00
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5mg
≥90% (mixture of isoforms)
in stock  
$168.00   $117.00
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10mg
≥90% (mixture of isoforms)
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$315.00   $220.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0038RN
Chemical Name:
Alamethicin (U-22324)
CAS Number:
27061-78-5
Molecular Formula:
C92H150N22O25
Molecular Weight:
1964.3078
MDL Number:
MFCD00151517
SMILES:
OC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C(NC(=O)C(NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)C(NC(=O)[C@@H](NC(=O)CNC(=O)C(NC(=O)[C@H](C(C)C)NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C(NC(=O)[C@@H](NC(=O)C(NC(=O)[C@@H]1CCCN1C(=O)C(NC(=O)C)(C)C)(C)C)C)(C)C)C)CCC(=O)N)(C)C)(C)C)CC(C)C)(C)C)(C)C)(C)C)CCC(=O)O)CCC(=O)N)Cc1ccccc1 C92H150N22O25
Properties
Computed Properties
 
Complexity:
4520  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
139  
Hydrogen Bond Acceptor Count:
25  
Hydrogen Bond Donor Count:
22  
Rotatable Bond Count:
53  
XLogP3:
-1.8  

Literature

Title: Control of leakage activities of alamethicin analogs by metals: side chain-dependent adverse gating response to Zn(2+).

Journal: Bioorganic & medicinal chemistry 20121201

Title: ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101

Title: Evaluation of molecularity of rate-limiting step of pore formation by antimicrobial peptides studied using mitochondria as a biosensor.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120901

Title: Cyclodextrin-scaffolded alamethicin with remarkably efficient membrane permeabilizing properties and membrane current conductance.

Journal: The journal of physical chemistry. B 20120705

Title: On-chip stochastic resonance of ion channel systems with variable internal noise.

Journal: IEEE transactions on nanobioscience 20120601

Title: Charge distribution and imperfect amphipathicity affect pore formation by antimicrobial peptides.

Journal: Biochimica et biophysica acta 20120501

Title: Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120501

Title: Observing a model ion channel gating action in model cell membranes in real time in situ: membrane potential change induced alamethicin orientation change.

Journal: Journal of the American Chemical Society 20120411

Title: Mechanical actuation of ion channels using a piezoelectric planar patch clamp system.

Journal: Lab on a chip 20120107

Title: Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens.

Journal: Microbiology (Reading, England) 20120101

Title: Mechanisms of peptide-induced pore formation in lipid bilayers investigated by oriented 31P solid-state NMR spectroscopy.

Journal: PloS one 20120101

Title: Imaging multiple conductance states in an alamethicin pore.

Journal: Journal of the American Chemical Society 20110921

Title: Tethered bilayer lipid micromembranes for single-channel recording: the role of adsorbed and partially fused lipid vesicles.

Journal: Physical chemistry chemical physics : PCCP 20110807

Title: Antimicrobial peptide killing of African trypanosomes.

Journal: Parasite immunology 20110801

Title: Toward understanding protocell mechanosensation.

Journal: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20110601

Title: Comparison of distance information in [TOAC(1) , Glu(OMe)(7, 18, 19) ] alamethicin F50/5 from paramagnetic relaxation enhancement measurements with data obtained from an X-ray diffraction-based model.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20110501

Title: cis- and trans-Regulation of miR163 and target genes confers natural variation of secondary metabolites in two Arabidopsis species and their allopolyploids.

Journal: The Plant cell 20110501

Title: Effects of cell differentiation and assay conditions on the UDP-glucuronosyltransferase activity in Caco-2 cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301

Title: Rb(+) occlusion stabilized by vanadate in gastric H(+)/K(+)-ATPase at 25°C.

Journal: Biochimica et biophysica acta 20110101

Title: Functional integration of membrane proteins with nanotube and nanowire transistor devices.

Journal: Methods in molecular biology (Clifton, N.J.) 20110101

Title: Correlation of intrinsic in vitro and in vivo clearance for drugs metabolized by hepatic UDP-glucuronosyltransferases in rats.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data.

Journal: Drug metabolism and pharmacokinetics 20110101

Title: Meet me on the other side: trans-bilayer modulation of a model voltage-gated ion channel activity by membrane electrostatics asymmetry.

Journal: PloS one 20110101

Title: Lipid-induced calcitonin fibrillation blocks membrane interactions of a peptide antibiotic.

Journal: The journal of physical chemistry. B 20101202

Title: Differences between human and rat intestinal and hepatic bisphenol A glucuronidation and the influence of alamethicin on in vitro kinetic measurements.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Hypersensitive-like response to the pore-former peptaibol alamethicin in Arabidopsis thaliana.

Journal: Chembiochem : a European journal of chemical biology 20100924

Title: Antimicrobial peptides bind more strongly to membrane pores.

Journal: Biochimica et biophysica acta 20100801

Title: Antimicrobial peptides in toroidal and cylindrical pores.

Journal: Biochimica et biophysica acta 20100801

Title: Alamethicin-induced electrical long distance signaling in plants.

Journal: Plant signaling & behavior 20100801

Title: Mitochondria as a source of mechanical signals in cardiomyocytes.

Journal: Cardiovascular research 20100701

Title: Effect of α-helical peptides on liposome structure: a comparative study of melittin and alamethicin.

Journal: Journal of colloid and interface science 20100601

Title: Fractional polymerization of a suspended planar bilayer creates a fluid, highly stable membrane for ion channel recordings.

Journal: Journal of the American Chemical Society 20100526

Title: Metal-assisted channel stabilization: disposition of a single histidine on the N-terminus of alamethicin yields channels with extraordinarily long lifetimes.

Journal: Biophysical journal 20100505

Title: Interactions of alamethicin with model cell membranes investigated using sum frequency generation vibrational spectroscopy in real time in situ.

Journal: The journal of physical chemistry. B 20100311

Title: Radio frequency rectification on membrane bound pores.

Journal: Nanotechnology 20100219

Title: Regulated attachment method for reconstituting lipid bilayers of prescribed size within flexible substrates.

Journal: Analytical chemistry 20100201

Title: Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells.

Journal: Molecular cancer 20100101

Title: Trichoderma viride cellulase induces resistance to the antibiotic pore-forming peptide alamethicin associated with changes in the plasma membrane lipid composition of tobacco BY-2 cells.

Journal: BMC plant biology 20100101

Title: Residue-specific information about the dynamics of antimicrobial peptides from (1)H-(15)N and (2)H solid-state NMR spectroscopy.

Journal: Journal of the American Chemical Society 20091230

Title: Experimental validation of the Helmoltz equation for the surface potential of Langmuir monolayers.

Journal: Physical review. E, Statistical, nonlinear, and soft matter physics 20091001

Title: Alamethicin aggregation in lipid membranes.

Journal: The Journal of membrane biology 20090901

Title: The RH 421 styryl dye induced, pore model-dependent modulation of antimicrobial peptides activity in reconstituted planar membranes.

Journal: Biochimica et biophysica acta 20090801

Title: Comparing induction at an early and late step in signal transduction mediating indirect defence in Brassica oleracea.

Journal: Journal of experimental botany 20090701

Title: Alamethicin in lipid bilayers: combined use of X-ray scattering and MD simulations.

Journal: Biochimica et biophysica acta 20090601

Title: In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.

Journal: The Journal of antibiotics 20090601

Title: Membrane order perturbation in the presence of antimicrobial peptides by (2)H solid-state NMR spectroscopy.

Journal: Biochimie 20090601

Title: Interactions of two transmembrane peptides in supported lipid bilayers studied by a (31)P and (15)N MAOSS NMR strategy.

Journal: Biochimie 20090601

Title: Induction of a non-specific permeability transition in mitochondria from Yarrowia lipolytica and Dipodascus (Endomyces) magnusii yeasts.

Journal: Journal of bioenergetics and biomembranes 20090601

Title: Incorporation of antimicrobial peptides into membranes: a combined liquid-state NMR and molecular dynamics study of alamethicin in DMPC/DHPC bicelles.

Journal: The journal of physical chemistry. B 20090514

Title: Conformational and interfacial analyses of K3A18K3 and alamethicin in model membranes.

Journal: The journal of physical chemistry. B 20090514

Title: Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance.

Journal: Pharmaceutical research 20090501

Title: Structure of self-aggregated alamethicin in ePC membranes detected by pulsed electron-electron double resonance and electron spin echo envelope modulation spectroscopies.

Journal: Biophysical journal 20090422

Title: Free energies of molecular bound states in lipid bilayers: lethal concentrations of antimicrobial peptides.

Journal: Biophysical journal 20090422

Title: Novel mycotoxin from Acremonium exuviarum is a powerful inhibitor of the mitochondrial respiratory chain complex III.

Journal: Chemical research in toxicology 20090316

Title: Alamethicin topology in phospholipid membranes by oriented solid-state NMR and EPR spectroscopies: a comparison.

Journal: The journal of physical chemistry. B 20090312

Title: Alamethicin-lipid interaction studied by energy dispersive X-ray diffraction.

Journal: Colloids and surfaces. B, Biointerfaces 20090301

Title: An automatic solid-phase synthesis of peptaibols.

Journal: The Journal of organic chemistry 20090206

Title: Intramembrane water associated with TOAC spin-labeled alamethicin: electron spin-echo envelope modulation by D2O.

Journal: Biophysical journal 20090204

Title: Orientation and peptide-lipid interactions of alamethicin incorporated in phospholipid membranes: polarized infrared and spin-label EPR spectroscopy.

Journal: Biochemistry 20090203

Title: Structure and alignment of the membrane-associated peptaibols ampullosporin A and alamethicin by oriented 15N and 31P solid-state NMR spectroscopy.

Journal: Biophysical journal 20090107

Title: Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090101

Title: Regulation of callose synthase activity in situ in alamethicin-permeabilized Arabidopsis and tobacco suspension cells.

Journal: BMC plant biology 20090101

Title: Peptide aggregation and pore formation in a lipid bilayer: a combined coarse-grained and all atom molecular dynamics study.

Journal: Biophysical journal 20081101

Title: PELDOR conformational analysis of bis-labeled alamethicin aggregated in phospholipid vesicles.

Journal: The journal of physical chemistry. B 20081030

Title: Aggregation of a peptide antibiotic alamethicin at the air-water interface and its influence on the viscoelasticity of phospholipid monolayers.

Journal: Langmuir : the ACS journal of surfaces and colloids 20081021

Title: Two-dimensional miscibility studies of alamethicin and selected film-forming molecules.

Journal: The journal of physical chemistry. B 20080703

Title: Structure of the alamethicin pore reconstructed by x-ray diffraction analysis.

Journal: Biophysical journal 20080501

Title: Lipid membrane domain formation and alamethicin aggregation studied by calorimetry, sound velocity measurements, and atomic force microscopy.

Journal: Biophysical chemistry 20080501

Title: mt-Nd2a suppresses reactive oxygen species production by mitochondrial complexes I and III.

Journal: The Journal of biological chemistry 20080418

Title: Backbone dynamics of alamethicin bound to lipid membranes: spin-echo electron paramagnetic resonance of TOAC-spin labels.

Journal: Biophysical journal 20080401

Title: Using ion channel-forming peptides to quantify protein-ligand interactions.

Journal: Journal of the American Chemical Society 20080130

Title: A practical guide on how osmolytes modulate macromolecular properties.

Journal: Methods in cell biology 20080101

Title: Lipid bilayer microarray for parallel recording of transmembrane ion currents.

Journal: Analytical chemistry 20080101

Title: Single-molecule investigation of the influence played by lipid rafts on ion transport and dynamic features of the pore-forming alamethicin oligomer.

Journal: The Journal of membrane biology 20080101

Title: Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition.

Journal: Journal of neurochemistry 20071201

Title: Entropy-driven softening of fluid lipid bilayers by alamethicin.

Journal: Langmuir : the ACS journal of surfaces and colloids 20071106

Title: pH modulation of transport properties of alamethicin oligomers inserted in zwitterionic-based artificial lipid membranes.

Journal: Biophysical chemistry 20071101

Title: Solid-state fermentation for Trichokonins production from Trichoderma koningii SMF2 and preparative purification of Trichokonin VI by a simple protocol.

Journal: Journal of biotechnology 20070831

Title: Determination of peptaibol trace amounts in marine sediments by liquid chromatography/electrospray ionization-ion trap-mass spectrometry.

Journal: Journal of chromatography. A 20070810

Title: Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20070801

Title: Self-aggregation of spin-labeled alamethicin in ePC vesicles studied by pulsed electron - electron double resonance.

Journal: Journal of the American Chemical Society 20070801

Title: Lipid chain-length dependence for incorporation of alamethicin in membranes: electron paramagnetic resonance studies on TOAC-spin labeled analogs.

Journal: Biophysical journal 20070601

Title: Interaction of alamethicin pores in DMPC bilayers.

Journal: Biophysical journal 20070601

Title: Total syntheses in solution of TOAC-labelled alamethicin F50/5 analogues.

Journal: Chemistry & biodiversity 20070601

Title: Conformational analysis of TOAC-labelled alamethicin F50/5 analogues.

Journal: Chemistry & biodiversity 20070601

Title: Solvent dependence of the rotational diffusion of TOAC-spin-labeled alamethicin.

Journal: Chemistry & biodiversity 20070601

Title: Supramolecular structure of self-assembling alamethicin analog studied by ESR and PELDOR.

Journal: Chemistry & biodiversity 20070601

Title: Alamethicin interaction with lipid membranes: a spectroscopic study on synthetic analogues.

Journal: Chemistry & biodiversity 20070601

Title: Membrane permeabilization of a mammalian neuroendocrine cell type (PC12) by the channel-forming peptides zervamicin, alamethicin, and gramicidin.

Journal: Chemistry & biodiversity 20070601

Title: Enzymatic reaction in a vesicular microreactor: peptaibol-facilitated substrate transport.

Journal: Chemistry & biodiversity 20070601

Title: The history of alamethicin: a review of the most extensively studied peptaibol.

Journal: Chemistry & biodiversity 20070601

Title: Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current.

Journal: Chemistry & biodiversity 20070601

Title: Channel-forming activity of alamethicin: effects of covalent tethering.

Journal: Chemistry & biodiversity 20070601

Title: Pore-forming properties of alamethicin F50/5 inserted in a biological membrane.

Journal: Chemistry & biodiversity 20070601

Title: Ion channels of N-terminally linked alamethicin dimers: enhancement of cation-selectivity by substitution of Glu for Gln at position 7.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20070501

Title: Simultaneous measurements of K+ and calcein release from liposomes and the determination of pore size formed in a membrane.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070501

Title: Septocylindrins A and B: peptaibols produced by the terrestrial fungus Septocylindrium sp. LL-Z1518.

Journal: Journal of natural products 20070301

Title: Defect formation of lytic peptides in lipid membranes and their influence on the thermodynamic properties of the pore environment.

Journal: Biochimica et biophysica acta 20070201

Title: TOAC spin labels in the backbone of alamethicin: EPR studies in lipid membranes.

Journal: Biophysical journal 20070115

Title: Crystal structure of a spin-labeled, channel-forming alamethicin analogue.

Journal: Angewandte Chemie (International ed. in English) 20070101

Title: Structure of magainin and alamethicin in model membranes studied by x-ray reflectivity.

Journal: Biophysical journal 20061101

Title: Phlorizin- and 6-ketocholestanol-mediated antagonistic modulation of alamethicin activity in phospholipid planar membranes.

Journal: Langmuir : the ACS journal of surfaces and colloids 20060926

Title: Selective transfer of energy through an alamethicin-doped artificial lipid membrane studied at discrete molecular level.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20060901

Title: Broad-spectrum antimicrobial activity and high stability of Trichokonins from Trichoderma koningii SMF2 against plant pathogens.

Journal: FEMS microbiology letters 20060701

Title: Voltage-dependent energetics of alamethicin monomers in the membrane.

Journal: Biophysical chemistry 20060620

Title: Transmission of extramembrane conformational change into current: construction of metal-gated ion channel.

Journal: Journal of the American Chemical Society 20060510

Title: Detection of new amino acid sequences of alamethicins F30 by nonaqueous capillary electrophoresis-mass spectrometry.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20060401

Title: Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation.

Journal: British journal of clinical pharmacology 20060401

Title: High-resolution electrophysiology on a chip: Transient dynamics of alamethicin channel formation.

Journal: Biochimica et biophysica acta 20060401

Title: Differential in vitro inhibition of M3G and M6G formation from morphine by (R)- and (S)-methadone and structurally related opioids.

Journal: British journal of clinical pharmacology 20060301

Title: Alamethicin influence on the membrane bending elasticity.

Journal: European biophysics journal : EBJ 20060201

Title: Imaging of voltage-gated alamethicin pores in a reconstituted bilayer lipid membrane via scanning electrochemical microscopy.

Journal: The Analyst 20060201

Title: Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101

Title: 4-Aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the UDP-glucuronosyltransferase isoforms.

Journal: Journal of applied toxicology : JAT 20060101

Title: [Studies of Ca2+ -dependent smooth muscle mitochondria swelling using flow cytometry and spermine effects on this process].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101

Title: Analysis of the lipophilic peptaibol alamethicin by nonaqueous capillary electrophoresis-electrospray ionization-mass spectrometry.

Journal: Electrophoresis 20051101

Title: Interaction of alamethicin with ether-linked phospholipid bilayers: oriented circular dichroism, 31P solid-state NMR, and differential scanning calorimetry studies.

Journal: Biophysical journal 20051001

Title: Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.

Journal: Anti-cancer drugs 20051001

Title: Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers.

Journal: The journal of physical chemistry. B 20050804

Title: Alamethicin permeabilizes the plasma membrane and mitochondria but not the tonoplast in tobacco (Nicotiana tabacum L. cv Bright Yellow) suspension cells.

Journal: The Biochemical journal 20050801

Title: Comparative kinetic analysis reveals that inducer-specific ion release precedes the mitochondrial permeability transition.

Journal: Biochimica et biophysica acta 20050715

Title: Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1.

Journal: The Journal of biological chemistry 20050603

Title: Impact of end-product inhibition on the determination of in vitro metabolic clearance.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050501

Title: Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons.

Journal: Journal of neurochemistry 20050301

Title: Possible involvement of glutamic and/or aspartic acid residue(s) and requirement of mitochondrial integrity for the protective effect of creatine against inhibition of cardiac mitochondrial respiration by methylglyoxal.

Journal: Molecular and cellular biochemistry 20050301

Title: Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein (CREB).

Journal: Journal of neurochemistry 20050101

Title: Peptaibols and related peptaibiotics of Trichoderma. A review.

Journal: Acta microbiologica et immunologica Hungarica 20050101

Title: Ca2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipin.

Journal: The Journal of biological chemistry 20041217

Title: Microscopic visualization of alamethicin incorporation into model membrane monolayers.

Journal: Langmuir : the ACS journal of surfaces and colloids 20041207

Title: The human TAZ gene complements mitochondrial dysfunction in the yeast taz1Delta mutant. Implications for Barth syndrome.

Journal: The Journal of biological chemistry 20041022

Title: High-performance liquid chromatography-based methods of enzymatic analysis: electron transport chain activity in mitochondria from human skeletal muscle.

Journal: Analytical biochemistry 20041001

Title: Conductance studies on trichotoxin_A50E and implications for channel structure.

Journal: Biophysical journal 20040901

Title: Conformation of peptides in lipid membranes studied by x-ray grazing incidence scattering.

Journal: Biophysical journal 20040701

Title: Absence of NADH channeling in coupled reaction of mitochondrial malate dehydrogenase and complex I in alamethicin-permeabilized rat liver mitochondria.

Journal: Biochemical and biophysical research communications 20040611

Title: Oxidation and reduction of pyridine nucleotides in alamethicin-permeabilized plant mitochondria.

Journal: The Biochemical journal 20040515

Title: Helical kink and channel behaviour: a comparative study with the peptaibols alamethicin, trichotoxin and antiamoebin.

Journal: European biophysics journal : EBJ 20040501

Title: Quantitative evaluation of the effects of mitochondrial permeability transition pore modifiers on accumulation of calcium phosphate: comparison of rat liver and brain mitochondria.

Journal: Archives of biochemistry and biophysics 20040401

Title: Energetics of pore formation induced by membrane active peptides.

Journal: Biochemistry 20040330

Title: Engineering charge selectivity in model ion channels.

Journal: Bioorganic & medicinal chemistry 20040315

Title: Real-time flow cytometry analysis of permeability transition in isolated mitochondria.

Journal: Experimental cell research 20040310

Title: Highly robust lipid membranes on crystalline S-layer supports investigated by electrochemical impedance spectroscopy.

Journal: Biochimica et biophysica acta 20040309

Title: Implicit solvent model estimates of the stability of model structures of the alamethicin channel.

Journal: European biophysics journal : EBJ 20040201

Title: Impedance analysis and single-channel recordings on nano-black lipid membranes based on porous alumina.

Journal: Biophysical journal 20040201

Title: Conformational changes in alamethicin associated with substitution of its alpha-methylalanines with leucines: a FTIR spectroscopic analysis and correlation with channel kinetics.

Journal: Biophysical journal 20040101

Title: Total synthesis in solution of alamethicin F50/5 by an easily tunable segment condensation approach.

Journal: Biopolymers 20040101

Title: Interactions of the M2delta segment of the acetylcholine receptor with lipid bilayers: a continuum-solvent model study.

Journal: Biophysical journal 20031201

Title: Amoebapores and NK-lysin, members of a class of structurally distinct antimicrobial and cytolytic peptides from protozoa and mammals: a comparative functional analysis.

Journal: The Biochemical journal 20031101

Title: The antibacterial peptide ceratotoxin A displays alamethicin-like behavior in lipid bilayers.

Journal: Peptides 20031101

Title: Microfabricated teflon membranes for low-noise recordings of ion channels in planar lipid bilayers.

Journal: Biophysical journal 20031001

Title: The implementation of slab geometry for membrane-channel molecular dynamics simulations.

Journal: Biophysical journal 20030701

Title: Ion channels of alamethicin dimer N-terminally linked by disulfide bond.

Journal: Biophysical journal 20030701

Title: Investigation of the role and mechanism of IF1 and STF1 proteins, twin inhibitory peptides which interact with the yeast mitochondrial ATP synthase.

Journal: Biochemistry 20030624

Title: The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030601

Title: Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation.

Journal: Biophysical journal 20030601

Title: N-terminal insertion of alamethicin in channel formation studied using its covalent dimer N-terminally linked by disulfide bond.

Journal: Biochimica et biophysica acta 20030502

Title: A tethered bilayer sensor containing alamethicin channels and its detection of amiloride based inhibitors.

Journal: Biosensors & bioelectronics 20030401

Title: Characterization of an ectonucleoside triphosphate diphosphohydrolase 1 activity in alkaline phosphatase-depleted rat osseous plate membranes: possible functional involvement in the calcification process.

Journal: Biochimica et biophysica acta 20030321

Title: Understanding pH-dependent selectivity of alamethicin K18 channels by computer simulation.

Journal: Biophysical journal 20030301

Title: In situ assay of the intramitochondrial enzymes: use of alamethicin for permeabilization of mitochondria.

Journal: Analytical biochemistry 20030201

Title: Simultaneous quantification of jasmonic acid and salicylic acid in plants by vapor-phase extraction and gas chromatography-chemical ionization-mass spectrometry.

Journal: Analytical biochemistry 20030115

Title: Metabolic assessment in liver microsomes by co-activating cytochrome P450s and UDP-glycosyltransferases.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: Channel properties of template assembled alamethicin tetramers.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20030101

Title: Template-free self-assembling fullerene and lipopeptide conjugates of alamethicin form voltage-dependent ion channels of remarkable stability and activity.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20030101

Title: Sequences of alamethicins F30 and F50 reconsidered and reconciled.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20030101

Title: Mechanosensing and signal transduction in tendrils.

Journal: Advances in space research : the official journal of the Committee on Space Research (COSPAR) 20030101

Title: Analysis and evaluation of channel models: simulations of alamethicin.

Journal: Biophysical journal 20021101

Title: Histone 2A stimulates glucose-6-phosphatase activity by permeabilization of liver microsomes.

Journal: The Biochemical journal 20021015

Title: Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice.

Journal: Biochemical and biophysical research communications 20020927

Title: Changes in lipid mobility associated with alamethicin incorporation into membranes.

Journal: Archives of biochemistry and biophysics 20020915

Title: Detection of protein-ligand interaction on the membranes using C-terminus biotin-tagged alamethicin.

Journal: Bioorganic & medicinal chemistry 20020801

Title: Modifications of alamethicin ion channels by substitution of Glu-7 for Gln-7.

Journal: Biophysical journal 20020701

Title: Pore formation and uncoupling initiate a Ca2+-independent degradation of mitochondrial phospholipids.

Journal: Biochemistry 20020618

Title: Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020601

Title: Synthesis and ion conductance behavior of a tetrameric alamethicin ion channel.

Journal: Organic letters 20020516

Title: Size distribution of barrel-stave aggregates of membrane peptides: influence of the bilayer lateral pressure profile.

Journal: Biophysical journal 20020501

Title: Characterization by liquid chromatography-nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry of two coupled oxidative-conjugative metabolic pathways for 7-ethoxycoumarin in human liver microsomes treated with alamethicin.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301

Title: Sigmoidal concentration dependence of antimicrobial peptide activities: a case study on alamethicin.

Journal: Biophysical journal 20020201

Title: The oat mitochondrial permeability transition and its implication in victorin binding and induced cell death.

Journal: The Plant journal : for cell and molecular biology 20020201

Title: Alamethicin-leucine zipper hybrid peptide: a prototype for the design of artificial receptors and ion channels.

Journal: Journal of the American Chemical Society 20011212

Title: Artificial membrane excitability revisited and implications for the gating of voltage-dependent ion channels.

Journal: General physiology and biophysics 20011201

Title: Voltage-dependent pore formation and antimicrobial activity by alamethicin and analogues.

Journal: The Journal of membrane biology 20011101

Title: Conformation of alamethicin in oriented phospholipid bilayers determined by (15)N solid-state nuclear magnetic resonance.

Journal: Biophysical journal 20010901

Title: 15N and 31P solid-state NMR investigations on the orientation of zervamicin II and alamethicin in phosphatidylcholine membranes.

Journal: Biochemistry 20010807

Title: Proline-induced hinges in transmembrane helices: possible roles in ion channel gating.

Journal: Proteins 20010801

Title: Peptaibols: models for ion channels.

Journal: Biochemical Society transactions 20010801

Title: Alamethicin channel conductance modified by lipid charge.

Journal: European biophysics journal : EBJ 20010801

Title: A high-throughput screen for identifying transmembrane pore-forming peptides.

Journal: Analytical biochemistry 20010615

Title: Catalytic activity of NADH-ubiquinone oxidoreductase (complex I) in intact mitochondria. evidence for the slow active/inactive transition.

Journal: The Journal of biological chemistry 20010323

Title: Ion channel-forming alamethicin is a potent elicitor of volatile biosynthesis and tendril coiling. Cross talk between jasmonate and salicylate signaling in lima bean.

Journal: Plant physiology 20010101

Title: Voltage-dependent insertion of alamethicin at phospholipid/water and octane/water interfaces.

Journal: Biophysical journal 20010101

Title: Ion channel are sensitive to gravity changes.

Journal: Microgravity science and technology 20010101

Title: Tissue distribution and interindividual variation in human UDP-glucuronosyltransferase activity: relationship between UGT1A1 promoter genotype and variability in a liver bank.

Journal: Pharmacogenetics 20001101

Title: Molecular dynamics simulation of conformational flexibility of alamethicin fragments in aqueous and membranous environment.

Journal: Journal of biomolecular structure & dynamics 19961201

Title: Protected 1-3 segment of the peptaibol antibiotics alamethicin and hypelcin. Solid-state and solution study of a stereochemically constrained linear peptide.

Journal: International journal of peptide and protein research 19831001

Title: Crystal and molecular structure of tert.-butyloxycarbonyl-L-prolyl-alpha-aminoisobutyryl-L-alanyl-alpha- aminoisobutyrate methyl ester.

Journal: International journal of peptide and protein research 19831001

Title: Conformations of synthetic alamethicin fragments. Evidence for 310 helical folding from 270-MHz hydrogen-1 nuclear magnetic resonance and circular dichroism studies.

Journal: Biochemistry 19810512

Title: Infrared studies on the conformation of synthetic alamethicin fragments and model peptides containing alpha-aminoisobutyric acid.

Journal: Biochemistry 19800205

Title: Rindfleisch H, et al. Biosynthesis of alamethicin. FEBS Lett. 1976 Mar 1;62(3):276-80.

Title: Olga S.Ostroumova, et al. Chapter Six - Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioning. International Review of Cell and Molecular Biology Volume 315, 2015, Pages 245-297.

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Tags:27061-78-5 Molecular Formula|27061-78-5 MDL|27061-78-5 SMILES|27061-78-5 Alamethicin (U-22324)