Title: Avascular tumour growth dynamics and the constraints of protein binding for drug transportation.
Journal: Journal of theoretical biology20121121
Title: Enhanced antitumor efficacy of cisplatin by tirapazamine-transferrin conjugate.
Journal: International journal of pharmaceutics20120715
Title: Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.
Journal: Journal of medicinal chemistry20120712
Title: A planned neck dissection is not necessary in all patients with N2-3 head-and-neck cancer after sequential chemoradiotherapy.
Journal: International journal of radiation oncology, biology, physics20120701
Title: Dinitroazetidines are a novel class of anticancer agents and hypoxia-activated radiation sensitizers developed from highly energetic materials.
Journal: Cancer research20120515
Title: Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation.
Journal: The British journal of surgery20120401
Title: Effects of tirapazamine on experimental colorectal liver metastases after radiofrequency ablation (Br J Surg 2012; 99: 567-575).
Journal: The British journal of surgery20120401
Title: On the reaction mechanism of tirapazamine reduction chemistry: unimolecular N-OH homolysis, stepwise dehydration, or triazene ring-opening.
Journal: Chemical research in toxicology20120319
Title: Electron and spin-density analysis of tirapazamine reduction chemistry.
Journal: Chemical research in toxicology20120319
Title: The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120315
Title: Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120315
Title: Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302.
Journal: Molecular cancer therapeutics20120301
Title: Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
Journal: Biochemical pharmacology20120301
Title: DNA strand cleavage by the phenazine di-N-oxide natural product myxin under both aerobic and anaerobic conditions.
Journal: Chemical research in toxicology20120113
Title: Prognostic significance of plasma osteopontin in patients with locoregionally advanced head and neck squamous cell carcinoma treated on TROG 02.02 phase III trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120101
Title: Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology.
Journal: Frontiers in genetics20120101
Title: Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy.
Journal: Frontiers in pharmacology20120101
Title: Tirapazamine-doxorubicin interaction referring to heart oxidative stress and Ca²⁺ balance protein levels.
Journal: Oxidative medicine and cellular longevity20120101
Title: Usefulness of combined treatment with continuous administration of tirapazamine and mild temperature hyperthermia in γ-ray irradiation in terms of local tumour response and lung metastatic potential.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group20120101
Title: Enhanced antitumor effect of tirapazamine delivered intraperitoneally to VX2 liver tumor-bearing rabbits subjected to transarterial hepatic embolization.
Journal: Cardiovascular and interventional radiology20111201
Title: Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.
Journal: Oncotarget20111201
Title: Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions.
Journal: Lab on a chip20111107
Title: Quinoxalino[2,3-c]cinnolines and their 5-N-oxide: alkoxylation of methyl-substituted quinoxalino[2,3-c]cinnolines to acetals and orthoesters.
Journal: The Journal of organic chemistry20111021
Title: Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era.
Journal: Journal of neuro-oncology20110801
Title: Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation.
Journal: Investigational new drugs20110601
Title: Targeting castration-induced tumour hypoxia enhances the acute effects of castration therapy in a rat prostate cancer model.
Journal: BJU international20110601
Title: Hypoxia-dependent retinal toxicity of NLCQ-1 (NSC 709257) in BALB/c mice. Comparison with tirapazamine.
Journal: Basic & clinical pharmacology & toxicology20110601
Title: Uroporphyrinogen decarboxylase: optimizing radiotherapy for head and neck cancer.
Journal: Future oncology (London, England)20110501
Title: Early toxicity predicts long-term survival in high-grade glioma.
Journal: British journal of cancer20110426
Title: Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Journal: European journal of medicinal chemistry20110301
Title: High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array.
Journal: The Analyst20110207
Title: Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.
Journal: Genome integrity20110101
Title: Investigation of tumor hypoxia using a two-enzyme system for in vitro generation of oxygen deficiency.
Journal: Radiation oncology (London, England)20110101
Title: Transport processes of radiopharmaceuticals and -modulators.
Journal: Radiation oncology (London, England)20110101
Title: Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104.
Journal: PloS one20110101
Title: A mathematical model for targeting chemicals to tissues by exploiting complex degradation.
Journal: Biology direct20110101
Title: Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice.
Journal: PloS one20110101
Title: Novel Phenazine 5,10-Dioxides Release OH in Simulated Hypoxia and Induce Reduction of Tumour Volume In Vivo.
Journal: ISRN pharmacology20110101
Title: Targeting hypoxic tumour cells to overcome metastasis.
Journal: BMC cancer20110101
Title: Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer.
Journal: International journal of breast cancer20110101
Title: Combined modality approaches in the management of adult glioblastoma.
Journal: Frontiers in oncology20110101
Title: Strategies for discovery of small molecule radiation protectors and radiation mitigators.
Journal: Frontiers in oncology20110101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20101201
Title: Henry S. Kaplan Distinguished Scientist Award Lecture 2007. The remarkable yin and yang of tumour hypoxia.
Journal: International journal of radiation biology20101101
Title: Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20101015
Title: Strategies to promote translational research within the European Organisation for Research and Treatment of Cancer (EORTC) Head and Neck Cancer Group: a report from the Translational Research Subcommittee.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20101001
Title: Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20100920
Title: p16 Expression as a predictive biomarker of hypoxic cell-sensitizing agents in oropharyngeal cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20100920
Title: Substantial improvement in UK cervical cancer survival with chemoradiotherapy: results of a Royal College of Radiologists' audit.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain))20100901
Title: Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs.
Journal: Anticancer research20100901
Title: Correlation of pharmacokinetic features and tissue distribution with toxicity of Q39, a hypoxic cell cytotoxic agent.
Journal: Die Pharmazie20100901
Title: The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy.
Journal: British journal of cancer20100713
Title: Phase 1 study of tirapazamine in combination with radiation and weekly cisplatin in patients with locally advanced cervical cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society20100701
Title: The tumor microenvironment in non-small-cell lung cancer.
Journal: Seminars in radiation oncology20100701
Title: Critical impact of radiotherapy protocol compliance and quality in the treatment of advanced head and neck cancer: results from TROG 02.02.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20100620
Title: Tirapazamine, cisplatin, and radiation versus cisplatin and radiation for advanced squamous cell carcinoma of the head and neck (TROG 02.02, HeadSTART): a phase III trial of the Trans-Tasman Radiation Oncology Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20100620
Title: Review of positron emission tomography tracers for imaging of tumor hypoxia.
Journal: Cancer biotherapy & radiopharmaceuticals20100601
Title: DNA strand cleaving properties and hypoxia-selective cytotoxicity of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide.
Journal: Bioorganic & medicinal chemistry20100501
Title: Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Journal: Journal of the American Chemical Society20100303
Title: Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
Journal: Endocrine-related cancer20100301
Title: Regulation of hypoxia-induced mRNA expressions of HIF-1alpha and osteopontin and in vitro radiosensitization by tirapazamine in human nasopharyngeal carcinoma HNE-1 and CNE-1 cells.
Journal: Chinese journal of cancer20100201
Title: Residual gammaH2AX foci as an indication of lethal DNA lesions.
Journal: BMC cancer20100101
Title: Effectiveness of combined modality radiotherapy of orthotopic human squamous cell carcinomas in Nu/Nu mice using cetuximab, tirapazamine and MnSOD-plasmid liposome gene therapy.
Journal: In vivo (Athens, Greece)20100101
Title: Hypoxia-inducible factor-1 as a therapeutic target in endometrial cancer management.
Journal: Obstetrics and gynecology international20100101
Title: Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety.
Journal: Advances in experimental medicine and biology20100101
Title: Architectural heterogeneity in tumors caused by differentiation alters intratumoral drug distribution and affects therapeutic synergy of antiangiogenic organoselenium compound.
Journal: Journal of oncology20100101
Title: XQ2, a novel TPZ derivative, induced G2/M phase arrest and apoptosis under hypoxia in non-small cell lung cancer cells.
Journal: Bioscience, biotechnology, and biochemistry20100101
Title: Hypoxia-specific targets in cancer therapy: role of splice variants.
Journal: BMC medicine20100101
Title: The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer.
Journal: Biologics : targets & therapy20100101
Title: A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer.
Journal: Radiation oncology (London, England)20100101
Title: Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.
Journal: PloS one20100101
Title: VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment.
Journal: BMC cancer20100101
Title: A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
Journal: British journal of cancer20091201
Title: Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.
Journal: British journal of cancer20091020
Title: Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase.
Journal: Journal of the American Chemical Society20091014
Title: Molecular imaging of hypoxia with radiolabelled agents.
Journal: European journal of nuclear medicine and molecular imaging20091001
Title: Increased tumor oxygenation and drug uptake during anti-angiogenic weekly low dose cyclophosphamide enhances the anti-tumor effect of weekly tirapazamine.
Journal: Current cancer drug targets20090901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20090901
Title: Ultrasensitive electrochemical sensing of the anticancer drug tirapazamine using an ordered mesoporous carbon modified pyrolytic graphite electrode.
Journal: Biosensors & bioelectronics20090715
Title: Detecting vascular-targeting effects of the hypoxic cytotoxin tirapazamine in tumor xenografts using magnetic resonance imaging.
Journal: International journal of radiation oncology, biology, physics20090701
Title: Phase II study of tirapazamine, cisplatin, and etoposide and concurrent thoracic radiotherapy for limited-stage small-cell lung cancer: SWOG 0222.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20090620
Title: Evaluation of the potential of hexamethylenetetramine, compared with tirapazamine, as a combined agent with {gamma}-irradiation and cisplatin treatment in vivo.
Journal: The British journal of radiology20090501
Title: Effects of cytokine-induced macrophages on the response of tumor cells to banoxantrone (AQ4N).
Journal: Molecular cancer therapeutics20090501
Title: Structural adaptation and heterogeneity of normal and tumor microvascular networks.
Journal: PLoS computational biology20090501
Title: Cytotoxic palladium complexes of bioreductive quinoxaline N1,N4-dioxide prodrugs.
Journal: Bioorganic & medicinal chemistry20090215
Title: Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
Journal: Journal of the American Chemical Society20090128
Title: A phase I pharmacokinetic study of hypoxic abdominal stop-flow perfusion with gemcitabine in patients with advanced pancreatic cancer and refractory malignant ascites.
Journal: Cancer chemotherapy and pharmacology20090101
Title: Tirapazamine: a novel agent targeting hypoxic tumor cells.
Journal: Expert opinion on investigational drugs20090101
Title: Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.
Journal: Bioinorganic chemistry and applications20090101
Title: A Model for NAD(P)H:Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy.
Journal: Drug target insights20090101
Title: A dialogue between the hypoxia-inducible factor and the tumor microenvironment.
Journal: Cancer microenvironment : official journal of the International Cancer Microenvironment Society20081201
Title: Tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins.
Journal: Journal of medicinal chemistry20081113
Title: Lower osteopontin plasma levels are associated with superior outcomes in advanced non-small-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20081010
Title: Quantitative measure of cytotoxicity of anticancer drugs and other agents.
Journal: Analytical biochemistry20081001
Title: Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors.
Journal: Bioorganic & medicinal chemistry20080915
Title: iNOS as a therapeutic target for treatment of human tumors.
Journal: Nitric oxide : biology and chemistry20080901
Title: Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts.
Journal: Neoplasia (New York, N.Y.)20080801
Title: In vivo 1H magnetic resonance spectroscopy of lactate in patients with stage IV head and neck squamous cell carcinoma.
Journal: International journal of radiation oncology, biology, physics20080715
Title: [Can tumor hypoxia be turned into a chemotherapeutic advantage?].
Journal: Bulletin du cancer20080501
Title: Carbonic anhydrase 9 (CA9) expression in tumor cells enhances sensitivity to tirapazamine.
Journal: Journal of cancer research and clinical oncology20080301
Title: Exploring vascular dysfunction caused by tirapazamine.
Journal: Microvascular research20080301
Title: Evaluation of the antiangiogenic potential of AQ4N.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20080301
Title: Hypoxic tumor cell radiosensitization: role of the iNOS/NO pathway.
Journal: Bulletin du cancer20080301
Title: Tirapazamine plus cisplatin and irradiation in a mouse model: improved tumor control at the cost of increased toxicity.
Journal: Journal of cancer research and clinical oncology20080201
Title: A review of topotecan in combination chemotherapy for advanced cervical cancer.
Journal: Therapeutics and clinical risk management20080201
Title: Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.
Journal: Cancer research20080101
Title: [The Oxygen effect: an old new target?].
Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique20080101
Title: Detection and specific targeting of hypoxic regions within solid tumors: current preclinical and clinical strategies.
Journal: Current medicinal chemistry20080101
Title: Pharmacokinetic/pharmacodynamic model-guided identification of hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with antitumor activity: the role of extravascular transport.
Journal: Journal of medicinal chemistry20071213
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20071201
Title: DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).
Journal: Journal of the American Chemical Society20071024
Title: Oxygen dependence and extravascular transport of hypoxia-activated prodrugs: comparison of the dinitrobenzamide mustard PR-104A and tirapazamine.
Journal: International journal of radiation oncology, biology, physics20071001
Title: Chemical radiosensitizers for use in radiotherapy.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain))20070801
Title: Bioreductive drugs: from concept to clinic.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain))20070801
Title: Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20070701
Title: Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts.
Journal: British journal of cancer20070618
Title: Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.
Journal: Radiation research20070601
Title: Beyond detection: novel applications for PET imaging to guide cancer therapy.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20070601
Title: Pretreatment 18F-FAZA PET predicts success of hypoxia-directed radiochemotherapy using tirapazamine.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20070601
Title: Increased nanoparticle penetration in collagenase-treated multicellular spheroids.
Journal: International journal of nanomedicine20070601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20070601
Title: [Inhibitory effect of tirapazamine combined with phosphatidylinositol 3-kinase inhibitor LY294002 to ovarian cancer cells].
Journal: Zhonghua yi xue za zhi20070508
Title: Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Journal: Archiv der Pharmazie20070501
Title: On the mechanism of reaction of radicals with tirapazamine.
Journal: Journal of the American Chemical Society20070418
Title: Phase I trial of tirapazamine, cisplatin, and concurrent accelerated boost reirradiation in patients with recurrent head and neck cancer.
Journal: International journal of radiation oncology, biology, physics20070301
Title: Effects of fluctuating oxygenation on tirapazamine efficacy: Theoretical predictions.
Journal: International journal of radiation oncology, biology, physics20070201
Title: The concurrent chemoradiation paradigm--general principles.
Journal: Nature clinical practice. Oncology20070201
Title: Assessment of DNA damage at the dimer level: measurement of the formamide lesion.
Journal: Radiation research20070201
Title: The usefulness of mild temperature hyperthermia combined with continuous tirapazamine administration under reduced dose-rate irradiation with gamma-rays.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group20070201
Title: Dependency of the effect of a vascular disrupting agent on sensitivity to tirapazamine and gamma-ray irradiation upon the timing of its administration and tumor size, with reference to the effect on intratumor quiescent cells.
Journal: Journal of cancer research and clinical oncology20070101
Title: Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells.
Journal: Radiation oncology (London, England)20070101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20070101
Title: DNA repair mechanisms are involved in the hypoxia-dependent toxicity of NLCQ-1 (NSC 709257) and its synergistic interaction with alkylating agents.
Journal: In vivo (Athens, Greece)20070101
Title: Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches.
Journal: International journal of radiation oncology, biology, physics20070101
Title: Hypoxia in head and neck cancer: studies with hypoxic positron emission tomography imaging and hypoxic cytotoxins.
Journal: International journal of radiation oncology, biology, physics20070101
Title: Tumor hypoxia in cancer therapy.
Journal: Methods in enzymology20070101
Title: Breast tumour angiogenesis.
Journal: Breast cancer research : BCR20070101
Title: Bevacizumab: the evidence for its clinical potential in the treatment of nonsmall cell lung cancer.
Journal: Core evidence20070101
Title: The usefulness of a continuous administration of tirapazamine combined with reduced dose-rate irradiation using {gamma}-rays or reactor thermal neutrons.
Journal: The British journal of radiology20061201
Title: New quinoxaline 1,4-di-N-oxides. Part 1: Hypoxia-selective cytotoxins and anticancer agents derived from quinoxaline 1,4-di-N-oxides.
Journal: Bioorganic & medicinal chemistry20061015
Title: Complete 1H, 13C and 15N NMR assignment of tirapazamine and related 1,2,4-benzotriazine N-oxides.
Journal: Magnetic resonance in chemistry : MRC20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20060901
Title: Respecting cancer drug transportability: a basis for successful lead selection.
Journal: Journal of the National Cancer Institute20060816
Title: Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.
Journal: Journal of the National Cancer Institute20060816
Title: Selective hypoxia-cytotoxins based on vanadyl complexes with 3-aminoquinoxaline-2-carbonitrile-N1,N4-dioxide derivatives.
Journal: Journal of inorganic biochemistry20060801
Title: Hypoxia: targeting the tumour.
Journal: Anti-cancer agents in medicinal chemistry20060701
Title: Concurrent chemoradiotherapy for locally advanced, nonmetastatic, squamous carcinoma of the head and neck: consensus, controversy, and conundrum.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20060610
Title: Mature results from a randomized Phase II trial of cisplatin plus 5-fluorouracil and radiotherapy with or without tirapazamine in patients with resectable Stage IV head and neck squamous cell carcinomas.
Journal: Cancer20060501
Title: Prognostic significance of [18F]-misonidazole positron emission tomography-detected tumor hypoxia in patients with advanced head and neck cancer randomly assigned to chemoradiation with or without tirapazamine: a substudy of Trans-Tasman Radiation Oncology Group Study 98.02.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20060501
Title: [Evaluation of the toxicity of tirapazamine plus cisplatin in a mouse tumor model].
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]20060401
Title: A phase II evaluation of tirapazamine plus cisplatin in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology20060301
Title: Radiation sensitization with redox modulators: a promising approach.
Journal: International journal of radiation oncology, biology, physics20060201
Title: Low-dose metronomic daily cyclophosphamide and weekly tirapazamine: a well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia.
Journal: Cancer research20060201
Title: Tirapazamine causes vascular dysfunction in HCT-116 tumour xenografts.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology20060201
Title: [Study on HPLC determination method and pharmacokinetics of tirapazaming in rabbits].
Journal: Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi20060201
Title: Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
Journal: Journal of the American Chemical Society20060111
Title: Tirapazamine plus cisplatin in advanced or recurrent carcinoma of the uterine cervix: a Southwest Oncology Group study.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society20060101
Title: Global analysis of gene function in yeast by quantitative phenotypic profiling.
Journal: Molecular systems biology20060101
Title: Phase II study of tirapazamine plus cisplatin in patients with advanced or recurrent cervical cancer.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society20060101
Title: Potentiation of alkylating agents by NLCQ-1 or TPZ in vitro and in vivo.
Journal: Journal of experimental therapeutics & oncology20060101
Title: Tirapazamine: from bench to clinical trials.
Journal: Current clinical pharmacology20060101
Title: Update on clinical radiobiology.
Journal: Biomedical imaging and intervention journal20060101
Title: Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: Southwest Oncology Group Trial S0003.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20051220
Title: Utility of FMISO PET in advanced head and neck cancer treated with chemoradiation incorporating a hypoxia-targeting chemotherapy agent.
Journal: European journal of nuclear medicine and molecular imaging20051201
Title: Synthesis of 3-amino-1,2,4-benzothiadi- azine 1,1-dioxides via a tandem aza-Wittig/heterocumulene annulation.
Journal: The Journal of organic chemistry20051125
Title: Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae.
Journal: Molecular pharmacology20051101
Title: Resistance to endocrine therapy in breast cancer.
Journal: Cancer chemotherapy and pharmacology20051101
Title: [Determination of the related substances in tirapazamine by high performance liquid chromatography].
Journal: Se pu = Chinese journal of chromatography20051101
Title: Anemia, tumor hypoxemia, and the cancer patient.
Journal: International journal of radiation oncology, biology, physics20050901
Title: Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells.
Journal: Oncology reports20050801
Title: The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines.
Journal: British journal of cancer20050711
Title: Hypoxia in head and neck cancer: how much, how important?
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Title: Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
Journal: Cancer research20050701
Title: Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Journal: Organic & biomolecular chemistry20050607
Title: Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20050601
Title: The usefulness of continuous administration of hypoxic cytotoxin combined with mild temperature hyperthermia, with reference to effects on quiescent tumour cell populations.
Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group20050601
Title: Tirapazamine cytotoxicity for neuroblastoma is p53 dependent.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20050401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20050401
Title: Time-resolved spectroscopy of the excited singlet states of tirapazamine and desoxytirapazamine.
Journal: The journal of physical chemistry. A20050303
Title: Tirapazamine with cisplatin and vinorelbine in patients with advanced non-small-cell lung cancer: a phase I/II study.
Journal: Clinical lung cancer20050301
Title: Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures.
Journal: Journal of medicinal chemistry20050224
Title: Tirapazamine, Cisplatin, and Radiation versus Fluorouracil, Cisplatin, and Radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02).
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20050101
Title: Improving survival and reducing toxicity with chemotherapy in advanced non-small cell lung cancer : a realistic goal?
Journal: Treatments in respiratory medicine20050101
Title: Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice.
Journal: BMC cancer20050101
Title: Prodrug research: futile or fertile?
Journal: Biochemical pharmacology20041201
Title: The Japanese experiences with hypoxia-targeting pharmacoradiotherapy: from hypoxic cell sensitisers to radiation-activated prodrugs.
Journal: Expert opinion on pharmacotherapy20041201
Title: [Phase II-trial of tirapazamine in combination with cisplatin and gemcitabine in patients with advanced non-small-cell-lung-cancer (NSCLC)].
Journal: Pneumologie (Stuttgart, Germany)20041201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20041201
Title: Enzyme-activated, hypoxia-selective DNA damage by 3-amino-2-quinoxalinecarbonitrile 1,4-di-N-oxide.
Journal: Chemical research in toxicology20041101
Title: Combined chemotherapy and radiation therapy for cervical cancer.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN20041101
Title: Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo.
Journal: British journal of cancer20041018
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20041001
Title: Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia.
Journal: British journal of cancer20040913
Title: Prospects for hypoxia-activated anticancer drugs.
Journal: Current medicinal chemistry. Anti-cancer agents20040901
Title: Cytochrome P450 CYP1B1 activity in renal cell carcinoma.
Journal: British journal of cancer20040831
Title: Phase I study of tirapazamine plus cisplatin/etoposide and concurrent thoracic radiotherapy in limited-stage small cell lung cancer (S0004): a Southwest Oncology Group study.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040815
Title: Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide.
Journal: Cancer research20040801
Title: Enhanced effectiveness of radiochemotherapy with tirapazamine by local application of electric pulses to tumors.
Journal: Radiation research20040801
Title: Clinical studies of hypoxia modification in radiotherapy.
Journal: Seminars in radiation oncology20040701
Title: Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Journal: Journal of the American Chemical Society20040630
Title: Oxygen dependence of the metabolic activation and cytotoxicity of tirapazamine: implications for extravascular transport and activity in tumors.
Journal: Radiation research20040601
Title: New derivatives of quinazoline and 1, 2-dihydroquinazoline n3-oxide with expected antitumor activity.
Journal: Archiv der Pharmazie20040501
Title: 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part II.
Journal: Archiv der Pharmazie20040501
Title: 1, 2, 4-Triazine N-oxide derivatives: studies as potential hypoxic cytotoxins. Part III.
Journal: Archiv der Pharmazie20040501
Title: Phase I trial of tirapazamine and cyclophosphamide in children with refractory solid tumors: a pediatric oncology group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20040415
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20040401
Title: 2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.
Journal: British journal of cancer20040308
Title: Enzyme-catalyzed activation of anticancer prodrugs.
Journal: Pharmacological reviews20040301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20040301
Title: Hypoxia targeted gene therapy to increase the efficacy of tirapazamine as an adjuvant to radiotherapy: reversing tumor radioresistance and effecting cure.
Journal: Cancer research20040215
Title: DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
Journal: Journal of medicinal chemistry20040115
Title: Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317.
Journal: Cancer research20040115
Title: The importance of DT-diaphorase and hypoxia in the cytotoxicity of RH1 in human breast and non-small cell lung cancer cell lines.
Journal: Anti-cancer drugs20040101
Title: Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro.
Journal: British journal of cancer20031201
Title: Endogenous markers of tumor hypoxia predictors of clinical radiation resistance?
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]20031201
Title: NLCQ-1 (NSC 709257): exploiting hypoxia with a weak DNA-intercalating bioreductive drug.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20031115
Title: Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
Journal: Chemical research in toxicology20031101
Title: The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models.
Journal: British journal of cancer20031020
Title: Human NADPH-cytochrome p450 reductase overexpression does not enhance the aerobic cytotoxicity of doxorubicin in human breast cancer cell lines.
Journal: Cancer research20031015
Title: Tirapazamine plus carboplatin and paclitaxel in advanced malignant solid tumors: a california cancer consortium phase I and molecular correlative study.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20031001
Title: DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Journal: Journal of the American Chemical Society20030924
Title: Multicellular resistance to tirapazamine is due to restricted extravascular transport: a pharmacokinetic/pharmacodynamic study in HT29 multicellular layer cultures.
Journal: Cancer research20030915
Title: Professor Tom Connors and the development of novel cancer therapies by the Phase I/II Clinical Trials Committee of Cancer Research UK.
Journal: British journal of cancer20030804
Title: A mass spectrometry study of tirapazamine and its metabolites. insights into the mechanism of metabolic transformations and the characterization of reaction intermediates.
Journal: Journal of the American Society for Mass Spectrometry20030801
Title: A simple method of producing low oxygen conditions with oxyrase for cultured cells exposed to radiation and tirapazamine.
Journal: American journal of clinical oncology20030801
Title: Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks.
Journal: Cancer research20030801
Title: Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies.
Journal: Cancer treatment reviews20030801
Title: Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients.
Journal: International journal of radiation oncology, biology, physics20030601
Title: Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro.
Journal: Molecular pharmacology20030601
Title: Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting.
Journal: Biochemical pharmacology20030601
Title: Antagonism of buthionine sulfoximine cytotoxicity for human neuroblastoma cell lines by hypoxia is reversed by the bioreductive agent tirapazamine.
Journal: Cancer research20030401
Title: Photochemical and photobiological studies of tirapazamine (SR 4233) and related quinoxaline 1,4-Di-N-oxide analogues.
Journal: Chemical research in toxicology20030201
Title: Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
Journal: Journal of the American Chemical Society20030122
Title: Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
Journal: Journal of medicinal chemistry20030102
Title: Potential of alpha-amino alcohol p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, regarding its enantiomers.
Journal: Journal of cancer research and clinical oncology20030101
Title: Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status.
Journal: Cancer science20030101
Title: Antiangiogenic hypoxic cytotoxin TX-402 inhibits hypoxia-inducible factor 1 signaling pathway.
Journal: Anticancer research20030101
Title: Therapeutic advantage from combining paclitaxel with the hypoxia-selective cytotoxin NLCQ-1 in murine tumor- or human xenograft-bearing mice.
Journal: Cancer chemotherapy and pharmacology20021201
Title: Platinum drugs in the treatment of non-small-cell lung cancer.
Journal: British journal of cancer20021007
Title: Therapeutic advantage from combining 5-fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo; comparison with tirapazamine.
Journal: Cancer chemotherapy and pharmacology20021001
Title: Tirapazamine: a hypoxia-activated topoisomerase II poison.
Journal: Cancer research20020915
Title: Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Journal: Bioorganic & medicinal chemistry letters20020902
Title: 5,6-dimethylxanthenone-4-acetic acid (DMXAA): a new biological response modifier for cancer therapy.
Journal: Investigational new drugs20020801
Title: Carbogen breathing after irradiation enhances the effectiveness of tirapazamine in SiHa tumors but not SCCVII tumors in mice.
Journal: Radiation research20020701
Title: Design, synthesis and biological activities of antiangiogenic hypoxic cytotoxin, triazine-N-oxide derivatives.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology20020501
Title: Photochemical electron transfer reactions of tirapazamine.
Journal: Photochemistry and photobiology20020401
Title: Significance of the response of quiescent cell populations within solid tumors in cancer therapy.
Journal: Journal of radiation research20020301
Title: The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
Journal: Cancer chemotherapy and pharmacology20020201
Title: Local hypoxia is produced at sites of intratumour injection.
Journal: British journal of cancer20020201
Title: Tirapazamine: prototype for a novel class of therapeutic agents targeting tumor hypoxia.
Journal: Seminars in oncology20020201
Title: Synergistic enhancement of the antitumor effect of taxol by the bioreductive compound NLCQ-1, in vivo: comparison with tirapazamine.
Journal: Oncology research20020101
Title: Hypoxic active drugs.
Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.]20020101
Title: Tumor microenvironment and the response to anticancer therapy.
Journal: Cancer biology & therapy20020101
Title: Metabolism of tirapazamine by multiple reductases in the nucleus.
Journal: Biochemical pharmacology20011101
Title: Optimizing the use of combined radioimmunotherapy and hypoxic cytotoxin therapy as a function of tumor hypoxia.
Journal: International journal of cancer20011101
Title: Evaluation of the potential of p-boronophenylalaninol as a boron carrier in boron neutron capture therapy, referring to the effect on intratumor quiescent cells.
Journal: Japanese journal of cancer research : Gann20010901
Title: Indications for chemotherapy in stage IV non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands)20010901
Title: Modeling the action of an antitumor drug: a density functional theory study of the mechanism of tirapazamine.
Journal: Journal of the American Chemical Society20010801
Title: Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes.
Journal: British journal of clinical pharmacology20010801
Title: The chemopotentiation of cisplatin by the novel bioreductive drug AQ4N.
Journal: British journal of cancer20010801
Title: Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and tirapazamine against EMT6 tumors in mice.
Journal: Cancer chemotherapy and pharmacology20010801
Title: Selective interaction of tirapazamine with DNA bases and DNA. A comparison of cyclic voltammetry and electrolysis techniques.
Journal: Free radical research20010801
Title: Radiosensitization effect by combination with paclitaxel in vivo, including the effect on intratumor quiescent cells.
Journal: International journal of radiation oncology, biology, physics20010715
Title: Inhibition of DNA replication by tirapazamine.
Journal: Cancer research20010715
Title: Phase I trial of i.v. administered tirapazamine plus cyclophosphamide.
Journal: Anti-cancer drugs20010701
Title: Recent advances in the chemotherapy of non-small cell lung cancer.
Journal: Japanese journal of clinical oncology20010701
Title: Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia.
Journal: Current medicinal chemistry20010601
Title: Triplet combination chemotherapy and targeted therapy regimens.
Journal: Oncology (Williston Park, N.Y.)20010301
Title: Therapeutic targets in radiotherapy.
Journal: International journal of radiation oncology, biology, physics20010201
Title: Phase I trial of concurrent tirapazamine, cisplatin, and radiotherapy in patients with advanced head and neck cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20010115
Title: 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Journal: The Journal of organic chemistry20010112
Title: Analysis of DNA damage in individual cells.
Journal: Methods in cell biology20010101
Title: An investigation of the molecular basis for the synergistic interaction of tirapazamine and cisplatin.
Journal: International journal of radiation oncology, biology, physics20010101
Title: Mitochondrial dysfunction after aerobic exposure to the hypoxic cytotoxin tirapazamine.
Journal: Cancer research20010101
Title: Cytotoxicity of bioreductive drug tirapazamine is increased by application of electric pulses in SA-1 tumours in mice.
Journal: Anticancer research20010101
Title: 4-[3-(2-Nitro-1-imidazolyl)propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive agent as radiosensitizer in vitro and in vivo: comparison with tirapazamine.
Journal: Oncology research20010101
Title: Hypoxia and oxidative stress. Tumour hypoxia--therapeutic considerations.
Journal: Breast cancer research : BCR20010101
Title: Targeting hypoxia in head and neck cancer.
Journal: Acta oncologica (Stockholm, Sweden)20010101
Title: Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy.
Journal: Cancer research20000715
Title: Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
Journal: British journal of cancer19950401
Title: SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells.
Journal: International journal of radiation oncology, biology, physics19860701
