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27523-40-6,MFCD00865084
Catalog No.:AA01E74B

27523-40-6 | Isoconazole

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1mg
4 weeks  
$429.00   $300.00
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2mg
4 weeks  
$572.00   $400.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E74B
Chemical Name:
Isoconazole
CAS Number:
27523-40-6
Molecular Formula:
C18H14Cl4N2O
Molecular Weight:
416.1286
MDL Number:
MFCD00865084
SMILES:
Clc1ccc(c(c1)Cl)C(Cn1cncc1)OCc1c(Cl)cccc1Cl
Properties
Computed Properties
 
Complexity:
407  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.3  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids.

Journal: Mycoses 20130501

Title: Reactive oxygen species and the bacteriostatic and bactericidal effects of isoconazole nitrate.

Journal: Mycoses 20130501

Title: Non-invasive analysis of penetration and storage of Isoconazole nitrate in the stratum corneum and the hair follicles.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120401

Title: Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

Journal: PLoS computational biology 20120201

Title: Generic systems for the enantioseparation of basic drugs in NACE using single-isomer anionic CDs.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Liquid chromatographic and spectrophotometric determination of diflucortolone valerate and isoconazole nitrate in creams.

Journal: Journal of AOAC International 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Otomycosis: Diagnosis and treatment.

Journal: Clinics in dermatology 20100304

Title: Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay.

Journal: PloS one 20090101

Title: Superficial dermatomycoses worldwide: multinational treatment experience with a combination of isoconazole nitrate and diflucortolone valerate. Introduction.

Journal: Mycoses 20080901

Title: The advantages of topical combination therapy in the treatment of inflammatory dermatomycoses.

Journal: Mycoses 20080901

Title: Successful therapy of tinea cruris with topical isoconazole in combination with a corticosteroid.

Journal: Mycoses 20080901

Title: The effective use of isoconazole nitrate and diflucortolone valerate cream in the treatment of inguino-femoral skin fold mycosis.

Journal: Mycoses 20080901

Title: Tinea cruris treated with a combined topical therapy containing isoconazole and a corticosteroid.

Journal: Mycoses 20080901

Title: Tinea corporis of the shin and chest successfully treated with a topical antifungal and corticosteroid cream.

Journal: Mycoses 20080901

Title: Tinea corporis treated with a combined topical therapy containing isoconazole and a corticosteroid.

Journal: Mycoses 20080901

Title: Tinea incognito due to Trichophyton rubrum responsive to topical therapy with isoconazole plus corticosteroid cream.

Journal: Mycoses 20080901

Title: Treatment of candidal intertrigo with a topical combination of isoconazole nitrate and diflucortolone valerate.

Journal: Mycoses 20080901

Title: Topical treatment of intertriginous candidal infection.

Journal: Mycoses 20080901

Title: Balanitis with eczematous perigenital intertriginous candidosis.

Journal: Mycoses 20080901

Title: Successful treatment of tinea pedis with a topical agent containing isoconazole nitrate and diflucortolone valerate.

Journal: Mycoses 20080901

Title: Step-wise treatment of athlete's foot (tinea pedis) using isoconazole combined with a corticosteroid followed by isoconazole alone.

Journal: Mycoses 20080901

Title: Dermatoscopy in the diagnosis of tinea nigra.

Journal: Dermatology online journal 20080815

Title: Molecular typing and antifungal susceptibility of Trichophyton rubrum isolates from patients with onychomycosis pre- and post-treatment.

Journal: International journal of antimicrobial agents 20070501

Title: Line-walking method for predicting the inhibition of P450 drug metabolism.

Journal: Journal of medicinal chemistry 20060713

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Susceptibility to some antifungal drugs of vaginal lactobacilli isolated from healthy women.

Journal: Drug metabolism and drug interactions 20050101

Title: In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis.

Journal: Chemotherapy 20041201

Title: [The problem of otomycosis treatment].

Journal: Voenno-meditsinskii zhurnal 20030201

Title: Pityriasis versicolor rubra.

Journal: European journal of dermatology : EJD 20020101

Title: [Vaginal candidiasis: etiology and sensitivity profile to antifungal agents in clinical use].

Journal: Revista Argentina de microbiologia 20010101

Title: [The in vitro properties of a new hydroxypyridone antimycotic rilopirox, with special reference to its anti-Candida activity].

Journal: The Japanese journal of antibiotics 19990201

Title: In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.

Journal: Mycopathologia 19920401

Title: Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes.

Journal: Mycoses 19920101

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