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2753-45-9,MFCD00083411
Catalog No.:AA00BBRA

2753-45-9 | Mebeverine hydrochloride

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BBRA
Chemical Name:
Mebeverine hydrochloride
CAS Number:
2753-45-9
Molecular Formula:
C25H35NO5
Molecular Weight:
429.5491
MDL Number:
MFCD00083411
SMILES:
COc1ccc(cc1)CC(N(CCCCOC(=O)c1ccc(c(c1)OC)OC)CC)C
Properties
Properties
 
Form:
Solid  
MP:
105-107 C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
494  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
14  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Fiber-based liquid-phase micro-extraction of mebeverine enantiomers followed by chiral high-performance liquid chromatography analysis and its application to pharmacokinetics study in rat plasma.

Journal: Chirality 20120801

Title: Support vector regression and artificial neural network models for stability indicating analysis of mebeverine hydrochloride and sulpiride mixtures in pharmaceutical preparation: a comparative study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120201

Title: Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201

Title: Treatment of IBS-D with 5-HT3 receptor antagonists vs spasmolytic agents: similar therapeutical effects from heterogeneous pharmacological targets.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20111201

Title: Preparation and in vitro evaluation of mebeverine HCl colon-targeted drug delivery system.

Journal: Pharmaceutical development and technology 20110801

Title: Quality of life in patients with irritable bowel syndrome.

Journal: Journal of clinical gastroenterology 20110801

Title: Quantitative HPLC analysis of mebeverine, mesalazine, sulphasalazine and dispersible aspirin stored in a Venalink monitored dosage system with co-prescribed medicines.

Journal: Journal of pharmaceutical and biomedical analysis 20110325

Title: [Effectiveness of duspatalin therapy in the treatment and prevention of post-cholecystectomy syndrome].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20110101

Title: [Chronic pancreatitis: microbe-intestinal tissue complex and systemic inflammatory response].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: [Significance of biliary dysfunction in the pathogenesis of gallstone disease].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20110101

Title: First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma.

Journal: Journal of fluorescence 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Development and validation of stability indicating HPLC and HPTLC methods for determination of sulpiride and mebeverine hydrochloride in combination.

Journal: European journal of medicinal chemistry 20100901

Title: Colloids as a sink for certain pharmaceuticals in the aquatic environment.

Journal: Environmental science and pollution research international 20100501

Title: Predictors of treatment outcome after cognitive behavior therapy and antispasmodic treatment for patients with irritable bowel syndrome in primary care.

Journal: Journal of psychosomatic research 20100401

Title: A systematic review of efficacy and tolerability of mebeverine in irritable bowel syndrome.

Journal: World journal of gastroenterology 20100207

Title: [Modern approaches to the therapy of biliary system diseases].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20100101

Title: Validated HPLC determination of the two fixed dose combinations (chlordiazepoxide hydrochloride and mebeverine hydrochloride; carvedilol and hydrochlorothiazide) in their tablets.

Journal: Journal of AOAC International 20100101

Title: Management of irritable bowel syndrome in primary care: feasibility randomised controlled trial of mebeverine, methylcellulose, placebo and a patient self-management cognitive behavioural therapy website. (MIBS trial).

Journal: BMC gastroenterology 20100101

Title: Validated LC-MS/MS method for determination of Alverine and one of its hydroxy metabolites in human plasma along with its application to a bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115

Title: Psychological associations of irritable bowel syndrome besides panic disorder: an often overlooked reality.

Journal: Scandinavian journal of gastroenterology 20090101

Title: [How to raise efficacy of gastroesophageal reflux disease treatment].

Journal: Terapevticheskii arkhiv 20090101

Title: [The effectiveness of spasmolytic therapy in chronic acalculous cholecystitis].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20090101

Title: [A method for non-medicamentous treatment of irritated bowel syndrome].

Journal: Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20090101

Title: Effects of 5-hydroxytryptamine (serotonin) type 3 antagonists on symptom relief and constipation in nonconstipated irritable bowel syndrome: a systematic review and meta-analysis of randomized controlled trials.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080501

Title: Cost-effectiveness of cognitive behaviour therapy in addition to mebeverine for irritable bowel syndrome.

Journal: European journal of gastroenterology & hepatology 20080401

Title: [Irritable bowel syndrome-an unbeloved problem].

Journal: MMW Fortschritte der Medizin 20080327

Title: Spectrophotometric determination of benzydamine HCl, levamisole HCl and mebeverine HCl through ion-pair complex formation with methyl orange.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080301

Title: [Efficacy of duspatalin in the treatment and prophylaxis of postcholecystectomic syndrome].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101

Title: Colon-specific drug delivery for mebeverine hydrochloride.

Journal: Journal of drug targeting 20071201

Title: A novel formulation for mebeverine hydrochloride.

Journal: Drug development and industrial pharmacy 20071001

Title: [Drug treatment of irritable bowel syndrome: an unmet need].

Journal: Gastroenterologia y hepatologia 20070301

Title: [Assessment of the efficacy of mebeverine in the complex therapy of chronic noncalculolis cholecystitis and biliary dysfunction].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

Title: Health technology assessment and ill-structured problems: a case study concerning the drug mebeverine.

Journal: International journal of technology assessment in health care 20070101

Title: [Chronic abdominal pain syndrome in biliary pathology].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101

Title: Formulation of an antispasmodic drug as a topical local anesthetic.

Journal: International journal of pharmaceutics 20061201

Title: Cognitive behavioural therapy in addition to antispasmodic therapy for irritable bowel syndrome in primary care: randomised controlled trial.

Journal: Health technology assessment (Winchester, England) 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: 'My patients are the sickest'.

Journal: European journal of gastroenterology & hepatology 20060501

Title: Quality of life of patients with irritable bowel syndrome is low compared to others with chronic diseases.

Journal: European journal of gastroenterology & hepatology 20060501

Title: Investigative implications of the instability and metabolism of mebeverine.

Journal: Journal of analytical toxicology 20060301

Title: A validated chiral HPLC method for the determination of mebeverine HCl enantiomers in pharmaceutical dosage forms and spiked rat plasma.

Journal: Biomedical chromatography : BMC 20060201

Title: Generic and brand-name drugs. Are different criteria sufficiently taken into account before granting market authorisation?

Journal: Acta clinica Belgica 20060101

Title: [The pain problem as a historic aspect. Pain at the biliary pathology. Mebeverine hydrochloride as a part of complex therapy].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20060101

Title: Mebeverine influences sodium ion transport in the distal colon.

Journal: Pharmacological reports : PR 20060101

Title: [Mebeverine for complex treatment of opisthorchiasis].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20060101

Title: [Determination of placebo effect in irritable bowel syndrome].

Journal: Deutsche medizinische Wochenschrift (1946) 20050826

Title: Cognitive behaviour therapy in addition to antispasmodic treatment for irritable bowel syndrome in primary care: randomised controlled trial.

Journal: BMJ (Clinical research ed.) 20050820

Title: Simultaneous determination of mebeverine hydrochloride and sulpiride using the first derivatives of ratio spectra and chemometric methods.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050801

Title: A new RP-HPLC method for analysis of mebeverine hydrochloride in raw materials and tablets.

Journal: Pakistan journal of pharmaceutical sciences 20050401

Title: Potentiometric flow injection analysis of mebeverine hydrochloride in serum and urine.

Journal: Journal of pharmaceutical and biomedical analysis 20050104

Title: Rapid accurate mass desorption electrospray ionisation tandem mass spectrometry of pharmaceutical samples.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Treatment patterns and health care costs of mebeverine-treated IBS patients: a case-control study.

Journal: Pharmacoepidemiology and drug safety 20041101

Title: Spectrophotometric microdetermination of nefopam, mebevrine and phenylpropanolamine hydrochloride in pharmaceutical formulations using alizarins.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701

Title: A double-blind randomised, placebo-controlled trial evaluating the influence of oral long-acting muscle relaxant (Mebeverine MR), and insufflation with CO(2) on pain associated with barium enema.

Journal: European radiology 20030701

Title: A pharmacokinetic comparison of the modified release capsule and a plain tablet formulation of mebeverine.

Journal: International journal of clinical practice 20021101

Title: Identification of mebeverine acid as the main circulating metabolite of mebeverine in man.

Journal: Journal of pharmaceutical and biomedical analysis 20020620

Title: [Mebeverine-retard in relief of pain in gallstone patients].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20020101

Title: [Duspatalin in functional disorders of the Oddi's sphincter in patients subjected cholecystectomy].

Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20020101

Title: The antispasmodic drug mebeverine leads to positive amphetamine results by fluorescence polarization immunoassay (FPIA)--studies on the toxicological analysis of urine by FPIA and GC-MS.

Journal: Journal of analytical toxicology 20010101

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