Home Amines 27589-33-9
27589-33-9,MFCD00867321
Catalog No.:AA002U3T

27589-33-9 | 2-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide

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100mg
97%
in stock  
$32.00   $22.00
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250mg
97%
in stock  
$56.00   $39.00
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1g
97%
in stock  
$109.00   $76.00
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5g
97%
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$368.00   $258.00
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10g
97%
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$652.00   $457.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002U3T
Chemical Name:
2-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide
CAS Number:
27589-33-9
Molecular Formula:
C12H11ClN6O2S2
Molecular Weight:
370.8377
MDL Number:
MFCD00867321
SMILES:
Clc1cc(NCc2cccs2)c(cc1S(=O)(=O)N)c1n[nH]nn1
Properties
Computed Properties
 
Complexity:
504  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
1.5  

Downstream Synthesis Route
Literature

Title: Comparative study of therapeutic effects of short- and long-acting loop diuretics in outpatients with chronic heart failure (COLD-CHF).

Journal: Journal of cardiology 20120501

Title: Comparative evaluation of two isobaric labeling tags, DiART and iTRAQ.

Journal: Analytical chemistry 20120320

Title: Superiority of long-acting to short-acting loop diuretics in the treatment of congestive heart failure.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: Amine metabolomics of hyperglycemic endothelial cells using capillary LC-MS with isobaric tagging.

Journal: Journal of proteome research 20111104

Title: Comparative analysis of the therapeutic effects of long-acting and short-acting loop diuretics in the treatment of chronic heart failure using (123)I-metaiodobenzylguanidine scintigraphy.

Journal: European journal of heart failure 20110801

Title: Deuterium isobaric amine-reactive tags for quantitative proteomics.

Journal: Analytical chemistry 20100915

Title: Beneficial effects of torasemide on systolic wall stress and sympathetic nervous activity in asymptomatic or mildly symptomatic patients with heart failure: comparison with azosemide.

Journal: Journal of cardiovascular pharmacology 20090601

Title: Assessment of diuretic effects and changes in plasma aldosterone concentration following oral administration of a single dose of furosemide or azosemide in healthy dogs.

Journal: American journal of veterinary research 20081201

Title: Chronic heart failure in Japan: implications of the CHART studies.

Journal: Vascular health and risk management 20080201

Title: The effect of retinoic acid on a zinc finger transcription factor, AJ18, during differentiation of a rat clonal preosteoblastic cell line, ROB-C20, into osteoblasts.

Journal: Archives of oral biology 20080101

Title: Rationale and design of a randomized trial to assess the effects of diuretics in heart failure: Japanese Multicenter Evaluation of Long- vs Short-Acting Diuretics in Congestive Heart Failure (J-MELODIC).

Journal: Circulation journal : official journal of the Japanese Circulation Society 20070701

Title: Mechanism of enhanced bioavailability and diuretic effect of azosemide by ascorbic acid in rats.

Journal: Life sciences 20060202

Title: Functional characterization of human monocarboxylate transporter 6 (SLC16A5).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201

Title: Different effects of long- and short-acting loop diuretics on survival rate in Dahl high-salt heart failure model rats.

Journal: Cardiovascular research 20051001

Title: [Efficacy and safety of azosemide in patients with edema and ascites].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050901

Title: Increase in intracellular Cl- concentration by cAMP- and Ca2+-dependent stimulation of M1 collecting duct cells.

Journal: Pflugers Archiv : European journal of physiology 20050201

Title: Pharmacokinetics and pharmacodynamics of azosemide.

Journal: Biopharmaceutics & drug disposition 20031001

Title: Expression and regulation of the Na+-K+-2Cl- cotransporter NKCC1 in the normal and CFTR-deficient murine colon.

Journal: The Journal of physiology 20030601

Title: Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagase analbuminemic rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030201

Title: Influence of 4-week and 8-week exercise training on the pharmacokinetics and pharmacodynamics of intravenous and oral azosemide in rats.

Journal: Life sciences 20020329

Title: Comparison of neurohumoral effects of short-acting and long-acting loop diuretics in patients with chronic congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20011001

Title: Human atrial natriuretic peptide is a useful criterion in treatment of nocturia.

Journal: Scandinavian journal of urology and nephrology 20010901

Title: Effects of cysteine on the pharmacokinetics and pharmacodynamics of intravenous and oral azosemide in rats with protein-calorie malnutrition.

Journal: Life sciences 20010413

Title: No effect of cysteine on the pharmacokinetics of intravenous azosemide in rats with protein-calorie malnutrition by pretreatment with 3-methylcholanthrene.

Journal: Research communications in molecular pathology and pharmacology 20010101

Title: Quantitative evaluation of ototoxic side effects of furosemide, piretanide, bumetanide, azosemide and ozolinone in the cat--a new approach to the problem of ototoxicity.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19851101

Title: Hampel P, et al. Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8(1):9877.

Title: Kim EJ, et al. Pharmacokinetics and pharmacodynamics of intravenous azosemide in mutant Nagaseanalbuminemic rats. Drug Metab Dispos. 2003 Feb;31(2):194-201.

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Tags:27589-33-9 Molecular Formula|27589-33-9 MDL|27589-33-9 SMILES|27589-33-9 2-Chloro-5-(2H-tetrazol-5-yl)-4-((thiophen-2-ylmethyl)amino)benzenesulfonamide