Home Bromides 27848-84-6
27848-84-6,MFCD00869626
Catalog No.:AA00I55P

27848-84-6 | [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
>98.0%(T)(HPLC)
in stock  
$43.00   $30.00
- +
1g
>98.0%(T)(HPLC)
in stock  
$253.00   $177.00
- +
5g
≥ 98%(HPLC,T)
in stock  
$1,147.00   $803.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00I55P
Chemical Name:
[(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate
CAS Number:
27848-84-6
Molecular Formula:
C24H26BrN3O3
Molecular Weight:
484.3855
MDL Number:
MFCD00869626
SMILES:
CO[C@]12C[C@@H](COC(=O)c3cncc(c3)Br)CN([C@@H]1Cc1c3c2cccc3n(c1)C)C
NSC Number:
757853
Properties
Computed Properties
 
Complexity:
681  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Literature

Title: Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer.

Journal: PLoS computational biology 20120201

Title: Reactivity of pulmonary circulation and right ventricle function to inhaled nitric oxide in systemic sclerosis patients.

Journal: Clinical rheumatology 20120101

Title: Systematic review on the efficacy and safety of herbal medicines for vascular dementia.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.

Journal: International journal of Alzheimer's disease 20120101

Title: Characterization of nicergoline polymorphs crystallized in several organic solvents.

Journal: Journal of pharmaceutical sciences 20110701

Title: Nicergoline improves dysphagia by upregulating substance P in the elderly.

Journal: Medicine 20110701

Title: New therapeutic approaches in the treatment of diabetic keratopathy: a review.

Journal: Clinical & experimental ophthalmology 20110401

Title: Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20110101

Title: The effects of intrathecal nicergoline and nimodipine in cerebral vasospasm: an experimental study in rabbits.

Journal: Acta neurochirurgica. Supplement 20110101

Title: The effects of nicergoline on corneal nerve regeneration in rat corneas after photorefractive keratectomy.

Journal: Current eye research 20110101

Title: Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations.

Journal: Chemistry Central journal 20110101

Title: Dysthymia and apathy: diagnosis and treatment.

Journal: Depression research and treatment 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Colloid formation by drugs in simulated intestinal fluid.

Journal: Journal of medicinal chemistry 20100527

Title: Nicergoline increases serum substance P levels in patients with an ischaemic stroke.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20100101

Title: Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.

Journal: Journal of neuroinflammation 20100101

Title: A systematic review of clinical trials of pharmacological interventions for acute ischaemic stroke (1955-2008) that were completed, but not published in full.

Journal: Trials 20100101

Title: [Therapeutic potential and possibilities of using of sermion (nicergoline) in neurological practice].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101

Title: Sertraline-induced rhabdomyolysis in an elderly patient with dementia and comorbidities.

Journal: The Annals of pharmacotherapy 20090701

Title: Natural non-trasgenic animal models for research in Alzheimer's disease.

Journal: Current Alzheimer research 20090401

Title: Effects of nicergoline on corneal epithelial wound healing in rat eyes.

Journal: Investigative ophthalmology & visual science 20090201

Title: [Glaucoma--neurodegenerative disease].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20090101

Title: Vascular cognitive impairment.

Journal: Indian journal of psychiatry 20090101

Title: Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21.

Journal: Journal of neurochemistry 20080501

Title: Method development and validation for the simultaneous determination of cinnarizine and co-formulated drugs in pharmaceutical preparations by capillary electrophoresis.

Journal: Journal of pharmaceutical and biomedical analysis 20080213

Title: Smart stability-indicating spectrophotometric methods for determination of binary mixtures without prior separation.

Journal: Journal of AOAC International 20080101

Title: Second-derivative synchronous fluorescence spectroscopy for the simultaneous determination of cinnarizine and nicergoline in pharmaceutical preparations.

Journal: Journal of AOAC International 20080101

Title: Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.

Journal: Neurotoxicology and teratology 20080101

Title: Therapeutic use of nicergoline.

Journal: Clinical drug investigation 20080101

Title: Progress update: Pharmacological treatment of Alzheimer's disease.

Journal: Neuropsychiatric disease and treatment 20071001

Title: Vascular dementia: pharmacological treatment approaches and perspectives.

Journal: Clinical interventions in aging 20070901

Title: Treating senile dementia with traditional Chinese medicine.

Journal: Clinical interventions in aging 20070601

Title: Donepezil in Alzheimer's disease: From conventional trials to pharmacogenetics.

Journal: Neuropsychiatric disease and treatment 20070601

Title: [Treatment of thyroid ophthalmopathy--a clinical case].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20070101

Title: [Influence of arterial hypertension on the clinical course of Parkinson's disease (PD) among middle-aged patients].

Journal: Likars'ka sprava 20070101

Title: [Treatment by medicine which improves cerebral circulation and metabolism].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20061128

Title: Supraspinal control of external anal sphincter motility: effects of vesical distension in humans and cats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20061101

Title: [Nicergoline, ibudilast, ifenprodil tartrate].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20061028

Title: An efficient separation and method development for the quantifying of two basic impurities of Nicergoline by reversed-phase high performance liquid chromatography using ion-pairing counter ions.

Journal: Journal of pharmaceutical and biomedical analysis 20061011

Title: Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions.

Journal: Chinese medicine 20060101

Title: Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes.

Journal: Brain research 20051220

Title: A phylogenetic survey of biliary lipids in vertebrates.

Journal: Journal of lipid research 20051001

Title: Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against beta-amyloid toxicity.

Journal: Brain research 20050614

Title: Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines.

Journal: BMC pharmacology 20050101

Title: [A case of pseudotumorous course of brain demyelinating disease].

Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

Title: [Effect of non-selective alpha-adrenergic receptor antagonist nicergoline on the activity of neurons in the ventral lateral thalamic nucleus].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20050101

Title: Nicergoline reverts haloperidol-induced loss of detoxifying-enzyme activity.

Journal: European journal of pharmacology 20041128

Title: Treatment of vascular dementia: evidence from trials with non-cholinergic drugs.

Journal: Journal of the neurological sciences 20041115

Title: Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes.

Journal: Biological & pharmaceutical bulletin 20040601

Title: Prolongevity medicine: Antagonic-Stress drug in distress, geriatrics, and related diseases. II. Clinical review--2003.

Journal: Annals of the New York Academy of Sciences 20040601

Title: [Nicergoline-induced Prinzmetal angina. 'Heartache' instead of headache].

Journal: Orvosi hetilap 20040104

Title: Sudden hearing loss as a first complication of long-standing Type 1 diabetes mellitus: a case report.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20040101

Title: Neuroprotection: a realistic goal for aged brain?

Journal: Advances in experimental medicine and biology 20040101

Title: Nicergoline in the treatment of dizziness in elderly patients. A review.

Journal: Archives of gerontology and geriatrics. Supplement 20040101

Title: [1-13C]Glucose entry in neuronal and astrocytic intermediary metabolism of aged rats. A study of the effects of nicergoline treatment by 13C NMR spectroscopy.

Journal: Brain research 20030314

Title: [Neurotransmitter mechanism of the tropoxin effect in comparison with other antimigraine preparations].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20030101

Title: Antioxidant properties of MDL and MMDL, two nicergoline metabolites, during chronic administration of haloperidol.

Journal: European journal of pharmacology 20021018

Title: First derivative ratio spectrophotometric, HPTLC-densitometric, and HPLC determination of nicergoline in presence of its hydrolysis-induced degradation product.

Journal: Journal of pharmaceutical and biomedical analysis 20021015

Title: Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes.

Journal: Investigative ophthalmology & visual science 20020801

Title: Plasticity of GABA(a) system during ageing: focus on vestibular compensation and possible pharmacological intervention.

Journal: Brain research 20020301

Title: Neuroprotection and aging of the cholinergic system: a role for the ergoline derivative nicergoline (Sermion).

Journal: Neuroscience 20020101

Title: Acute interstitial nephritis due to nicergoline (Sermion).

Journal: Nephron 20020101

Title: [Nicergoline in the treatment of patients after a mild ischemic stroke].

Journal: Neurologia i neurochirurgia polska 20020101

Title: [Sermion in the treatment of patients with neurological diseases].

Journal: Voenno-meditsinskii zhurnal 20010801

Title: Effect of an alpha-blocker (Nicergoline) and of a beta-blocker (Acebutolol) on the in vitro biosynthesis of vascular extracellular matrix.

Journal: Pathologie-biologie 20010501

Title: Immunoassays for the detection of nicergoline and its metabolites in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20010401

Title: Pulmonary function in men after repeated sessions of oxygen breathing at 0.25 MPa for 90 min.

Journal: Aviation, space, and environmental medicine 20010301

Title: Inhibitory effect of nicergoline on superoxide generation by activated rat microglias measured using a simple chemiluminescence method.

Journal: Neuroscience letters 20010105

Title: [Current strategies of pathogenetic therapy of Alzheimer's disease].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20010101

Title: Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment.

Journal: The Cochrane database of systematic reviews 20010101

Title: [A case of parkinsonism induced by an oral contraceptive].

Journal: No to shinkei = Brain and nerve 19920201

Title: Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats.

Journal: Psychopharmacology 19920101

Title: [Pharmacological analysis of memory disorders of different origins].

Journal: Biulleten' eksperimental'noi biologii i meditsiny 19890601

Title: Effect of nicergoline on learning and memory.

Journal: Methods and findings in experimental and clinical pharmacology 19880701

Title: [The effects of nicergoline on the heart rate in the normotensive or spontaneously hypertensive rat. Possible participation of central alpha-1 receptors].

Journal: Journal de pharmacologie 19860101

Title: [Nicergoline to reduce intraoperative blood pressure increases in hypertensive patients].

Journal: Cahiers d'anesthesiologie 19851101

Title: Centrally mediated cardiovascular effects of nicergoline in the dog compared to those of clonidine.

Journal: European journal of pharmacology 19851029

Title: [Plasma renin activity and prostaglandin E2 in hypotension induced by nicergoline].

Journal: Annales francaises d'anesthesie et de reanimation 19850101

Title: Systemic and carotid haemodynamics and plasma renin activity during deliberate hypotension in dogs: a comparison of sodium nitroprusside with nicergoline.

Journal: European journal of anaesthesiology 19840301

Title: [Haemodynamic and metabolic effects of exercise test in diabetic patients with arteritis treated or not with nicergoline (author's transl)].

Journal: La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19810901

Title: Effects of nicergoline on the cardiovascular system of dogs and rats.

Journal: Journal of cardiovascular pharmacology 19810101

Title: Some haemodynamic effects of nicergoline, a new alpha-blocking agent, in the closed-chest anaesthetized dog as compared with nitroprusside and nitroglycerin.

Journal: Arzneimittel-Forschung 19810101

Title: DDT-induced myoclonus: serotonin and alpha noradrenergic interaction.

Journal: Research communications in chemical pathology and pharmacology 19790201

Title: Alvarez-Guerra, M., N. Bertholom, and R.P. Garay, Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol, 1999. 13(1): p. 50-8.

Title: Zang G, et, al. Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 2018 May;17(5):7293-7300.

Title: Mizuno T, et, al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066(1-2):78-85.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:27848-84-6 Molecular Formula|27848-84-6 MDL|27848-84-6 SMILES|27848-84-6 [(2S,4R,7R)-2-methoxy-6,11-dimethyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]methyl 5-bromopyridine-3-carboxylate |Heterocyclic_Building_Blocks