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Home Other Building Blocks 278779-30-9
278779-30-9,MFCD09971006
Catalog No.:AA0039MF

278779-30-9 | Gw 4064

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$15.00   $11.00
- +
5mg
98%
in stock  
$37.00   $26.00
- +
10mg
98%
in stock  
$54.00   $38.00
- +
100mg
95%
in stock  
$376.00   $263.00
- +
250mg
98%
in stock  
$407.00   $285.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039MF
Chemical Name:
Gw 4064
CAS Number:
278779-30-9
Molecular Formula:
C28H22Cl3NO4
Molecular Weight:
542.8376
MDL Number:
MFCD09971006
SMILES:
Clc1cc(ccc1C=Cc1cccc(c1)C(=O)O)OCc1c(onc1c1c(Cl)cccc1Cl)C(C)C
Properties
Computed Properties
 
Complexity:
742  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  
XLogP3:
8.3  

Literature

Title: Akwabi-Ameyaw A, et al.Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064. Bioorg Med Chem Lett, 2008, 18(15), 4339-4343.

Title: Ma Y, et al. Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and resistance. Pharm Res. 2013 May;30(5):1447-57.

Title: Liu Y, et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest. 2003 Dec;112(11):1678-87.

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SDS
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Tags:278779-30-9 Molecular Formula|278779-30-9 MDL|278779-30-9 SMILES|278779-30-9 Gw 4064