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Home Amines 28081-19-8
28081-19-8,MFCD00017963
Catalog No.:AA00C3UU

28081-19-8 | 4-(Dimethylamino)-4'-fluorochalcone

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Purity
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250mg
95%
in stock  
$95.00   $67.00
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1g
95
in stock  
$102.00   $72.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C3UU
Chemical Name:
4-(Dimethylamino)-4'-fluorochalcone
CAS Number:
28081-19-8
Molecular Formula:
C17H16FNO
Molecular Weight:
269.3134
MDL Number:
MFCD00017963
SMILES:
Fc1ccc(cc1)C(=O)/C=C/c1ccc(cc1)N(C)C
Properties
Computed Properties
 
Complexity:
337  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Downstream Synthesis Route

[1]JournalofPharmaceuticalSciences,1992,vol.81,p.892-894

[1]JournalofPharmaceuticalSciences,1992,vol.81,p.892-894

[2]MedicinalChemistryResearch,2015,vol.24,p.2580-2590

[3]SpectrochimicaActa-PartA:MolecularandBiomolecularSpectroscopy,2016,vol.152,p.318-326

[4]ChemicalBiologyandDrugDesign,2011,vol.78,p.94-100

[5]RSCAdvances,2016,vol.6,p.7723-7727

[6]ArchivderPharmazie,2016,p.539-552

[7]BioorganicChemistry,2021,vol.108

[8]BioorganicandMedicinalChemistryLetters,2021,vol.48

[1]Mao,Zewei;Zheng,Xi;Lin,Yuping;Qi,Yan;Hu,Chunyan;Wan,Chunping;Rao,Gaoxiong[Heterocycles,2016,vol.92,#6,p.1102-1110]

[2]Kaide,Sho;Ono,Masahiro;Watanabe,Hiroyuki;Shimizu,Yoichi;Nakamoto,Yuji;Togashi,Kaori;Yamaguchi,Aiko;Hanaoka,Hirofumi;Saji,Hideo[BioorganicandMedicinalChemistry,2018,vol.26,#12,p.3352-3358]

[3]CurrentPatentAssignee:NAGASAKIUNIVERSITY-EP2030635,2009,A1Locationinpatent:Page/Pagecolumn40;58

[4]Katiyar,SarvagyaS.;Latithambica,M.[IndianJournalofChemistry,SectionA:Inorganic,Physical,TheoreticalandAnalytical,1980,vol.19,#10,p.956-960]

[5]Locationinpatent:experimentalpartOno,Masahiro;Watanabe,Rumi;Kawashima,Hidekazu;Yan,Cheng;Kimura,Hiroyuki;Watanabe,Hiroyuki;Haratake,Mamoru;Saji,Hideo;Nakayama,Morio[JournalofMedicinalChemistry,2009,vol.52,#20,p.6394-6401]

[6]Yang,Wen;Cheng,Zhongqin;Xu,Yunlong;Shao,Jie;Zhou,Weiqun;Xie,Juan;Li,Mengying[NewJournalofChemistry,2015,vol.39,#9,p.7488-7494]

[7]Sahu,Meeta;Siddiqui,Nadeem;Naim,Mohd.Javed;Alam,Ozair;Yar,MohammadShahar;Sharma,Vidushi;Wakode,Sharad[ArchivderPharmazie,2017,vol.350,#9]

[8]Xie,Chuan;Zhang,Siyu;Zhang,Wei;Wu,Chunxia;Yong,Can;Sun,Yuhao;Zeng,Zhengxing;Zhang,Qian;Huang,Zixin;Chen,Tian;Zhang,Yuanyuan[ChemicalBiologyandDrugDesign,2020,vol.96,#2,p.836-849]

[1]JournaloftheIndianChemicalSociety,1988,vol.65,p.134-136

[1]JournalfurpraktischeChemie(Leipzig1954),1981,vol.323,p.49-54

Literature

Title: Fluoro-pegylated chalcones as positron emission tomography probes for in vivo imaging of beta-amyloid plaques in Alzheimer's disease.

Journal: Journal of medicinal chemistry 20091022

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SDS
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