Home Fluorides 284028-89-3
284028-89-3,MFCD16879017
Catalog No.:AA0039CE

284028-89-3 | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$19.00   $14.00
- +
5mg
98%(HPLC)
in stock  
$43.00   $30.00
- +
10mg
98%
in stock  
$74.00   $52.00
- +
25mg
98%(HPLC)
in stock  
$124.00   $87.00
- +
50mg
98%
in stock  
$167.00   $117.00
- +
100mg
98%
in stock  
$270.00   $189.00
- +
250mg
98%
in stock  
$461.00   $323.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0039CE
Chemical Name:
3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one
CAS Number:
284028-89-3
Molecular Formula:
C14H11F3N2OS
Molecular Weight:
312.3101
MDL Number:
MFCD16879017
SMILES:
O=c1nc([nH]c2c1CSCC2)c1ccc(cc1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
505  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
2.3  

Downstream Synthesis Route

[1]Sather,AaronC.;Lee,HongGeun;DeLaRosa,ValentinaY.;Yang,Yang;Müller,Peter;Buchwald,StephenL.[JournaloftheAmericanChemicalSociety,2015,vol.137,#41,p.13433-13438]

[1]Sather,AaronC.;Lee,HongGeun;DeLaRosa,ValentinaY.;Yang,Yang;Müller,Peter;Buchwald,StephenL.[JournaloftheAmericanChemicalSociety,2015,vol.137,#41,p.13433-13438]

[1]Sather,AaronC.;Lee,HongGeun;DeLaRosa,ValentinaY.;Yang,Yang;Müller,Peter;Buchwald,StephenL.[JournaloftheAmericanChemicalSociety,2015,vol.137,#41,p.13433-13438]

Literature

Title: WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.

Journal: Oncogene 20150601

Title: Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions.

Journal: Toxicology and applied pharmacology 20150415

Title: Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth.

Journal: Fertility and sterility 20140501

Title: Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.

Journal: Genes & cancer 20140501

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulates proliferation of HAPI microglia by affecting the Akt/GSK-3β/cyclin D1 signaling pathway.

Journal: Toxicology letters 20140130

Title: Novel binding mode of a potent and selective tankyrase inhibitor.

Journal: PloS one 20120101

Title: Huang SM, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-620.

Title: Dregalla RC, et al. Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs. Aging (Albany NY). 2010 Oct;2(10):691-708.

Title: Ao A, et al. DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells.,PLoS One. 2012;7(7):e41627.

Title: Zeng L, et al. Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model. Int Immunopharmacol. 2014 Jan;18(1):175-81.

Title: Bai J, et al. Epigenetic downregulation of SFRP4 contributes to epidermal hyperplasia in psoriasis. J Immunol. 2015 May 1;194(9):4185-98. doi: 10.4049/jimmunol.1403196. Epub 2015 Mar 30.

Title: Narwal M, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9.

Title: Liu D, et al. Wnt/β-catenin signaling participates in the regulation of lipogenesis in the liver of juvenile turbot (Scophthalmus maximus L.). Comp Biochem Physiol B Biochem Mol Biol. 2016 Jan;191:155-62.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 284028-89-3
Tags:284028-89-3 Molecular Formula|284028-89-3 MDL|284028-89-3 SMILES|284028-89-3 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |Heterocyclic_Building_Blocks