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285986-88-1,MFCD01566719
Catalog No.:AA002VQA

285986-88-1 | Ccg-1423

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Purity
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Price(USD)
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1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$15.00   $11.00
- +
10mg
98%
in stock  
$22.00   $15.00
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50mg
98%
in stock  
$60.00   $42.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002VQA
Chemical Name:
Ccg-1423
CAS Number:
285986-88-1
Molecular Formula:
C18H13ClF6N2O3
Molecular Weight:
454.7508
MDL Number:
MFCD01566719
SMILES:
O=C(C(ONC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)Nc1ccc(cc1)Cl
NSC Number:
742825
Properties
Properties
 
Form:
Solid  
Solubility:
DMSO: soluble5mg/mL, clear (warmed)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
586  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.9  

Literature

Title: Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Journal: The Journal of pharmacology and experimental therapeutics 20140601

Title: Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.

Journal: Cell 20140130

Title: Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Journal: Bioorganic & medicinal chemistry letters 20130701

Title: Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance.

Journal: The Journal of clinical investigation 20110301

Title: Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.

Journal: Biochemical and biophysical research communications 20100319

Title: Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423.

Journal: Bioorganic & medicinal chemistry letters 20100115

Title: Signaling through Rho GTPase pathway as viable drug target.

Journal: Current medicinal chemistry 20090101

Title: CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling.

Journal: Molecular cancer therapeutics 20070801

Title: Evelyn CR, et al. Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423. Bioorg Med Chem Lett. 2010 Jan 15;20(2):665-72.

Title: Jin W, et al. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar;121(3):918-29.

Title: Chong NW, et al. STARS is essential to maintain cardiac development and function in vivo via a SRF pathway. PLoS One. 2012;7(7):e40966.

Title: Duggirala A, et al. cAMP-induced actin cytoskeleton remodelling inhibits MKL1-dependent expression of the chemotactic and pro-proliferative factor, CCN1. J Mol Cell Cardiol. 2014 Nov 18;79C:157-168.

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