Home Quinolines 287383-59-9
287383-59-9,MFCD00386477
Catalog No.:AA002W8C

287383-59-9 | 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-

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1mg
98%
in stock  
$11.00   $8.00
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5mg
98%
in stock  
$23.00   $16.00
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10mg
98%
in stock  
$33.00   $23.00
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50mg
98%
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$86.00   $61.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002W8C
Chemical Name:
1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-
CAS Number:
287383-59-9
Molecular Formula:
C18H18N2O4
Molecular Weight:
326.3465
MDL Number:
MFCD00386477
SMILES:
ONC(=O)CCCCCn1c(=O)c2cccc3c2c(c1=O)ccc3
Properties
Computed Properties
 
Complexity:
477  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2  

Literature

Title: Scriptaid effects on breast cancer cell lines.

Journal: Journal of cellular physiology 20121001

Title: Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos.

Journal: Biology of reproduction 20111101

Title: AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5.

Journal: The Journal of biological chemistry 20110506

Title: Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors.

Journal: Hepatology (Baltimore, Md.) 20110301

Title: Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos.

Journal: The Journal of reproduction and development 20110201

Title: Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.

Journal: Experimental biology and medicine (Maywood, N.J.) 20101101

Title: HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity.

Journal: Journal of cellular and molecular medicine 20100801

Title: Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines.

Journal: International journal of molecular medicine 20100801

Title: Histone deacetylase inhibitors de-repress tyrosine hydroxylase expression in the olfactory bulb and rostral migratory stream.

Journal: Biochemical and biophysical research communications 20100319

Title: Chemical phylogenetics of histone deacetylases.

Journal: Nature chemical biology 20100301

Title: Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos.

Journal: Cellular reprogramming 20100201

Title: Scriptaid, a novel histone deacetylase inhibitor, enhances the response of human tumor cells to radiation.

Journal: International journal of molecular medicine 20100101

Title: Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.

Journal: Nature chemical biology 20100101

Title: Histone deacetylase inhibitor uses p21(Cip1) to maintain anergy in CD4+ T cells.

Journal: International immunopharmacology 20091001

Title: Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer.

Journal: Biology of reproduction 20090901

Title: The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice.

Journal: Reproduction (Cambridge, England) 20090801

Title: Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages.

Journal: Archives of pharmacal research 20090401

Title: Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells.

Journal: International journal of oncology 20081001

Title: Acetylation of histone H3 and adrenergic-regulated gene transcription in rat pinealocytes.

Journal: Endocrinology 20071001

Title: Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro.

Journal: The Journal of parasitology 20070601

Title: Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy.

Journal: Circulation 20060606

Title: A novel histone deacetylase inhibitor, Scriptaid, induces growth inhibition, cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells.

Journal: International journal of molecular medicine 20060201

Title: Fetal hemoglobin induction by the histone deacetylase inhibitor, scriptaid.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20050905

Title: Induction of human gamma globin gene expression by histone deacetylase inhibitors.

Journal: Blood 20040115

Title: (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine.

Journal: Breast cancer research and treatment 20031001

Title: A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.

Journal: Cancer research 20000615

Title: Keen JC, et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res Treat. 2003 Oct;81(3):177-86.

Title: Strobl JS, et al. Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro. J Parasitol. 2007 Jun;93(3):694-700.

Title: Janaki Ramaiah M, et al. Scriptaid cause histone deacetylase inhibition and cell cycle arrest in HeLa cancer cells: A study on structural and functional aspects. Gene. 2017 Sep 5;627:379-386.

Title: Ghosh SK, et al. Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Blood. 2012 Jan 26;119(4):1008-17.

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Tags:287383-59-9 Molecular Formula|287383-59-9 MDL|287383-59-9 SMILES|287383-59-9 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-