Title: Isothiazole and isoxazole fused pyrimidones as PDE7 inhibitors: SAR and pharmacokinetic evaluation.
Journal: Bioorganic & medicinal chemistry letters 20120501
Title: Lurasidone hydro-chloride.
Journal: Acta crystallographica. Section E, Structure reports online 20120501
Title: Diarylheterocycle core ring features effect in selective COX-1 inhibition.
Journal: ChemMedChem 20120401
Title: 3-Phenyl-5-isothiazole carboxamides with potent mGluR1 antagonist activity.
Journal: Bioorganic & medicinal chemistry letters 20120401
Title: 3D-QSAR and molecular docking studies on substituted isothiazole analogs as inhibitors against MEK-1 kinase.
Journal: Chemical biology & drug design 20120101
Title: Cytotoxic effects of chemotherapeutic drugs and heterocyclic compounds at application on the cells of primary culture of neuroepithelium tumors.
Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20120101
Title: Application of 2-trichloromethylbenzimidazole in analytical chemistry: a highly selective chromogenic reagent for thin-layer chromatography and some other analytical uses.
Journal: Journal of analytical methods in chemistry 20120101
Title: Critical appraisal of lurasidone in the management of schizophrenia.
Journal: Neuropsychiatric disease and treatment 20120101
Title: Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer.
Journal: PloS one 20120101
Title: Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
Journal: Chemical research in toxicology 20101115
Title: In silico exploration for identifying structure-activity relationship of MEK inhibition and oral bioavailability for isothiazole derivatives.
Journal: Chemical biology & drug design 20101101
Title: Ligand-exchange processes on solvated zinc cations: water exchange on [Zn(H2O)4(L)]2+.2H2O (L=heterocyclic ligand).
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100625
Title: Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.
Journal: European journal of medicinal chemistry 20100501
Title: Synthesis and pharmacological evaluation of thiazole and isothiazole derived apomorphines.
Journal: Archiv der Pharmazie 20091001
Title: Synthesis of novel vanillin derivatives containing isothiazole moieties and its synergistic effect in mixtures with insecticides.
Journal: Natural product communications 20090901
Title: Synthesis and immunomodulatory activites of new 5-hydrazino-3-methyl-4-isothiazolecarboxylic acid ethyl esters.
Journal: Acta poloniae pharmaceutica 20090101
Title: New amides of 5-(4-chlorobenzoyl)aminoorotic acid: their synthesis and biological activity.
Journal: Archiv der Pharmazie 20081101
Title: Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20080815
Title: Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.
Journal: Organic & biomolecular chemistry 20070207
Title: New derivatives of 5-amino-3-methyl-4-isothiazolecarboxylic acid and their immunological activity.
Journal: Acta poloniae pharmaceutica 20070101
Title: Isothiazole derivatives as antiviral agents.
Journal: Antiviral chemistry & chemotherapy 20070101
Title: New regiospecific isothiazole C-C coupling chemistry.
Journal: Organic & biomolecular chemistry 20061007
Title: Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists.
Journal: Bioorganic & medicinal chemistry letters 20060701
Title: New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity.
Journal: Archiv der Pharmazie 20060701
Title: Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation.
Journal: Biochemical pharmacology 20051205
Title: Isothiazole derivatives as novel HIV replication inhibitors.
Journal: Antiviral chemistry & chemotherapy 20040701
Title: Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.
Journal: European journal of pharmacology 20040223
Title: Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.
Journal: Cancer research 20031101
Title: Regiospecific Suzuki coupling of 3,5-dichloroisothiazole-4-carbonitrile.
Journal: Organic & biomolecular chemistry 20030821
Title: Novel synthesis and reactions of 5,7-dialkyl-4,6-dioxo-4,5,6,7-tetrahydro- isothiazolo[3,4,-d]pyrimidine-3-carbonitriles and 6-methyl-4-oxo-4H-1-aza-5-oxa-2- thiaindene-3-carbonitrile.
Journal: Organic letters 20030220
Title: [Biological activity of the isothiazole derivatives].
Journal: Postepy higieny i medycyny doswiadczalnej 20030101
Title: [Synthesis and monolayer behaviors of 4-methyl-5-hydroxy-ethyl isothiazole stearic ester].
Journal: Guang pu xue yu guang pu fen xi = Guang pu 20021201
Title: Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.
Journal: Bioorganic & medicinal chemistry letters 20020819
Title: Synthesis of new 3-methylthio-5-aryl-4-isothiazolecarbonitriles with broad antiviral spectrum.
Journal: Antiviral research 20020801
Title: Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of substituted isothiazol.
Journal: Nucleosides, nucleotides & nucleic acids 20010301
